OR52B2 Olfactory Receptor
| Gene Symbol | OR52B21 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | OR11-70, HsOR11.3.101, ORL3403 |
| External Ids | HGNC: 15207 GeneBank: AB065763, AB065939, AF399505, BK004324, NM_001004052 ORDB: ORL3403 |
| Build #39 labels | OR52B2 |
| Chromosomal location | 11:6,169,358-6,170,326 (-) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52B1P | 70.03% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52H1C | 67% | 301 |
| Mouse | Or52b2 | 88% | 322 |
| Rat | Or52b2 | 89% | 322 |
| Cow | OR52H2 | 66% | 305 |
| Orang | OR52B1P | 72% | 303 |
| Horse | OR52H1 | 65% | 301 |
| Chimp | OR52B2P | 96% | 324 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136733 |
| GNF Atlas2 | gnf1h05408_s_at |
Sequence information
| Nucleotide sequence |
ATGAGTCACACCAATGTTACCATCTTCCATCCTGCAGTTTTTGTCCTTCCTGGCATCCCT GGGTTGGAGGCTTATCACATTTGGCTGTCAATACCTCTTTGCCTCATTTACATCACTGCA GTCCTGGGAAACAGCATCCTGATAGTGGTTATTGTCATGGAACGTAACCTTCATGTGCCC ATGTATTTCTTCCTCTCAATGCTGGCCGTCATGGACATCCTGCTGTCTACCACCACTGTG CCCAAGGCCCTAGCCATCTTTTGGCTTCAAGCACATAACATTGCTTTTGATGCCTGTGTC ACCCAAGGCTTCTTTGTCCATATGATGTTTGTGGGGGAGTCAGCTATCCTGTTAGCCATG GCCTTTGATCGCTTTGTGGCCATTTGTGCCCCACTGAGATATACAACAGTGCTAACATGG CCTGTTGTGGGGAGGATTGCTCTGGCCGTCATCACCCGAAGCTTCTGCATCATCTTCCCA GTCATATTCTTGCTGAAGCGGCTGCCCTTCTGCCTAACCAACATTGTTCCTCACTCCTAC TGTGAGCATATTGGAGTGGCTCGTTTAGCCTGTGCTGACATCACTGTTAACATTTGGTAT GGCTTCTCAGTGCCCATTGTCATGGTCATCTTGGATGTTATCCTCATCGCTGTGTCTTAC TCACTGATCCTCCGAGCAGTGTTTCGTTTGCCCTCCCAGGATGCTCGGCACAAGGCCCTC AGCACTTGTGGCTCCCACCTCTGTGTCATCCTTATGTTTTATGTTCCATCCTTCTTTACC TTATTGACCCATCATTTTGGGCGTAATATTCCTCAACATGTCCATATCTTGCTGGCCAAT CTTTATGTGGCAGTGCCACCAATGCTGAACCCCATTGTCTATGGTGTGAAGACTAAGCAG ATACGTGAGGGTGTAGCCCACCGGTTCTTTGACATCAAGACTTGGTGCTGTACCTCCCCT CTGGGCTCA |
| Conceptual translation |
MSHTNVTIFHPAVFVLPGIPGLEAYHIWLSIPLCLIYITAVLGNSILIVVIVMERNLHVP MYFFLSMLAVMDILLSTTTVPKALAIFWLQAHNIAFDACVTQGFFVHMMFVGESAILLAM AFDRFVAICAPLRYTTVLTWPVVGRIALAVITRSFCIIFPVIFLLKRLPFCLTNIVPHSY CEHIGVARLACADITVNIWYGFSVPIVMVILDVILIAVSYSLILRAVFRLPSQDARHKAL STCGSHLCVILMFYVPSFFTLLTHHFGRNIPQHVHILLANLYVAVPPMLNPIVYGVKTKQ IREGVAHRFFDIKTWCCTSPLGS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 6,191,243 | 6,191,243 | NS | A/T | F/Y | rs16909422 (DbSNP) |
| 11 | 6,191,003 | 6,191,003 | NS | C/G | G/A | rs7483525 (DbSNP) |
| 11 | 6,191,109 | 6,191,109 | NS | C/T | V/I | rs11040779 (DbSNP) |
| 11 | 6,190,974 | 6,190,974 | NS | C/T | A/T | rs35364339 (DbSNP) |
| 11 | 6,191,478 | 6,191,478 | NS | T/G | I/L | rs61738682 (DbSNP) |
| 11 | 6,191,008 | 6,191,008 | SYN | A/G | H/H | rs7480755 (DbSNP) |
| 11 | 6,169,620 | 6,169,620 | NS | C/T | R/Q | 1000GP (CEU) |
| 11 | 6,169,879 | 6,169,879 | NS | C/T | V/I | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | C/T | R/H | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | F/F | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
| 11 | 6,189,710 | 6,193,096 | CopyNumber | Variation_65854 (DGV) |
| 11 | 6,189,746 | 6,193,323 | CopyNumber | Variation_85637 (DGV) |
| 11 | 6,188,588 | 6,191,656 | Deletion, CopyNumber | #295 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R268H | M252L | R236Q | V150I | F105Y | I46T | I27L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | R | M | R | V | F | I | I | 91.63 | 0.038 |
| 2 | R | M | R | V | Y | I | I | 3.07 | 0.038 |
| 3 | R | M | Q | V | F | I | I | 2.30 | 0.038 |
| 4 | R | M | R | V | Y | I | L | 2.00 | 0.038 |
| 5 | R | L | R | V | F | T | I | 0.46 | 0.038 |
| 6 | H | M | R | V | Y | I | I | 0.31 | 0.038 |
| 7 | R | M | R | I | F | I | I | 0.15 | 0.038 |
| 8 | H | M | R | V | F | I | I | 0.08 | 0.038 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52B2.aApr07-unspliced | main_exon | 3UTR | chr11 | 6,169,355 | 6,169,358 | - |
| CDS | chr11 | 6,169,358 | 6,170,326 | - | ||