OR52B4 Olfactory Receptor
| Gene Symbol | OR52B41 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.89 (pseudogene) |
| Aliases | OR11-3, HsOR11.3.2, ORL3326, ORL3406 |
| External Ids | HGNC: 15209 GeneBank: AB065792, BK004256, NM_001005161 ORDB: ORL3326, ORL3406 |
| Build #39 labels | OR52B4 |
| Chromosomal location | 11:4,367,354-4,368,295 (-) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a polymorphism of C->del at position 119 (rs11310407) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52B3P | 63.38% | 314 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52B4BP | 82% | 314 |
| Mouse | Or52b4 | 85% | 310 |
| Rat | Or52b4 | 77% | 314 |
| Cow | OR52B4C | 82% | 314 |
| Orang | OR52B33P | 73% | 315 |
| Horse | OR52B4GP | 84% | 314 |
| Horse | OR52B4HP | 83% | 314 |
| Horse | OR52B4E | 82% | 313 |
| Chimp | OR52B3 | 64% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BG997275 |
| mRNA | BC140928 |
| GNF Atlas2 | gnf1h05797_at |
Sequence information
| Nucleotide sequence |
ATGCCTACTGTAAACCACAGTGGCACTAGCCACACAGTCTTCCACTTGCTGGGCATCCCT GGCCTACAGGACCAGCACATGTGGATTTCTATCCCATTCTTCATTTCCTATGTCACCGCC CTTCTTGGGAACAGCCTGCTCATCTTCATTATCCTCACAAAGCGCAGCCTCCATGAACCC ATGTACCTCTTCCTCTGCATGCTGGCTGGAGCAGACATTGTCCTCTCCACGTGCACCATT CCTCAGGCCTTAGCTATCTTCTGGTTCCGTGCTGGGGACATCTCCCTGGATCGTTGCATC ACTCAGCTCTTCTTCATCCATTCCACCTTCATCTCTGAGTCAGGGATCTTGCTGGTGATG GCCTTTGACCACTATATTGCCATATGCTACCCACTGAGGTACACCACCATTCTTACAAAT GCTCTGATCAAGAAAATTTGTGTGACTGTCTCTCTGAGAAGTTATGGTACAATTTTCCCT ATCATATTTCTTTTAAAAAGATTGACTTTCTGCCAGAATAATATTATTCCACACACCTTT TGTGAACACATTGGCCTAGCCAAATATGCATGTAATGACATTCGAATAAACATTTGGTAT GGGTTTTCCATTCTAATGTCGACGGTGGTCTTAGATGTTGTACTAATTTTTATTTCCTAT ATGCTGATTCTCCATGCTGTCTTCCACATGCCTTCTCCAGATGCTTGCCACAAAGCTCTC AACACATTTGGCTCCCATGTCTGCATCATCATCCTCTTTTATGGGTCTGGCATCTTCACA ATCCTTACCCAGAGGTTTGGACGCCACATTCCACCTTGTATCCACATCCCGTTGGCTAAT GTCTGCATTCTGGCTCCACCTATGCTGAATCCCATTATTTATGGGATCAAAACCAAGCAA ATCCAGGAACAGGTGGTTCAGTTTTTGTTTATAAAACAGAAA |
| Conceptual translation |
MPTVNHSGTSHTVFHLLGIPGLQDQHMWISIPFFISYVTALLGNSLLIFIILTKRSLHEP MYLFLCMLAGADIVLSTCTIPQALAIFWFRAGDISLDRCITQLFFIHSTFISESGILLVM AFDHYIAICYPLRYTTILTNALIKKICVTVSLRSYGTIFPIIFLLKRLTFCQNNIIPHTF CEHIGLAKYACNDIRINIWYGFSILMSTVVLDVVLIFISYMLILHAVFHMPSPDACHKAL NTFGSHVCIIILFYGSGIFTILTQRFGRHIPPCIHIPLANVCILAPPMLNPIIYGIKTKQ IQEQVVQFLFIKQK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 4,389,407 | 4,389,407 | Del(1) | -/G | rs11310407 (DbSNP) | |
| 11 | 4,389,110 | 4,389,110 | NS | A/G | I/T | rs11031961 (DbSNP) |
| 11 | 4,388,879 | 4,388,879 | NS | G/A | T/I | rs61732898 (DbSNP) |
| 11 | 4,388,905 | 4,388,905 | SYN | C/T | S/S | rs11031960 (DbSNP) |
| 11 | 4,389,024 | 4,389,024 | SYN | G/A | L/L | rs61910719 (DbSNP) |
| 11 | 4,367,590 | 4,367,590 | NS | A/G | C/R | 1000GP (CEU) |
| 11 | 4,367,675 | 4,367,675 | SYN | C/T | S/S | 1000GP (CEU, CHBJPT) |
| 11 | 4,367,979 | 4,367,979 | NS | A/G | I/T | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | A/G | I/T | 1000GP (YRI) |
| 11 | 100 | -100 | SYN | C/T | S/S | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 4,333,543 | 4,474,341 | CopyNumber | Variation_2164 (DGV) |
| 11 | 4,055,945 | 4,510,188 | CopyNumber | Variation_3834 (DGV) |
| 11 | 4,238,115 | 4,393,578 | CopyNumber | Variation_75520 (DGV) |
| 11 | 4,203,352 | 4,393,578 | CopyNumber | Variation_85620 (DGV) |
| 11 | 4,249,760 | 4,393,578 | CopyNumber | Variation_85621 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I216T | I106T | % Freq | CORP | |
|---|---|---|---|---|
| 1 | I | I | 99.00 | 0.884 |
| 2 | T | I | 0.92 | 0.884 |
| 3 | I | T | 0.08 | 0.884 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52B4.aApr07-unspliced | main_exon | 3UTR | chr11 | 4,367,351 | 4,367,354 | - |
| CDS | chr11 | 4,367,354 | 4,368,295 | - | ||