OR52B6 Olfactory Receptor
| Gene Symbol | OR52B61 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.09 (functional) |
| Aliases | HsOR11.3.74, ORL3424 |
| External Ids | HGNC: 15211 ORDB: ORL3424 |
| Build #39 labels | OR52B6 |
| Chromosomal location | 11:5,580,940-5,581,881 (+) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52B2 | 59.73% | 298 |
| OR52B5P | 56.67% | 300 |
| OR52Z1P | 60.27% | 297 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52Z1B | 60% | 310 |
| Mouse | Or52b6-ps | 80% | 315 |
| Rat | Or52b6-ps | 80% | 315 |
| Cow | OR52Z1 | 63% | 300 |
| Orang | OR52B6P | 89% | 303 |
| Horse | OR52Z1 | 59% | 311 |
| Chimp | OR52B6P | 96% | 314 |
Sequence information
| Nucleotide sequence |
ATGAACAACTCTGACACTCGCATAGCAGGCTGCTTCCTCACTGGCATCCCTGGGCTGGAG CAACTACATATCTGGCTGTCCATCCCCTTCTGCATCATGTACATCACTGCCCTGGAAGGC AATGGCATCCTAATTTGTGTCATCCTCTCCCAGGCAATCCTGCATGAGCCCATGTACATA TTCTTATCTATGCTGGCCAGTGCTGATGTCTTGCTCTCTACCACCACCATGCCTAAGGCC CTGGCCAATTTGTGGCTAGGTTATAGCCTCATTTCCTTTGATGGCTGCCTCACTCAGATG TTCTTCATTCACTTCCTCTTCATTCACTCTGCTGTCCTGCTGGCCATGGCCTTTGACCGC TATGTGGCCATCTGCTCCCCCCTGCGATATGTCACAATCCTCACAAGCAAGGTCATTGGG AAGATCGTCACTGCCGCCCTGAGCCACAGCTTCATCATTATGTTTCCATCCATCTTTCTC CTTGAGCACCTGCACTATTGCCAGATCAATATCATTGCACACACATTTTGTGAGCACATG GGCATTGCCCATCTGTCCTGTTCTGATATCTCCATCAATGTCTGGTATGGGTTGGCAGCT GCTCTTCTCTCCACAGGCCTAGACATCATGCTTATTACTGTTTCCTACATCCACATCCTC CAAGCAGTCTTCCGCCTCCTTTCTCAAGATGCCCGCTCCAAGGCCCTGAGTACCTGTGGA TCCCATATCTGTGTCATCCTACTCTTCTATGTCCCTGCGCTTTTTTCTGTCTTTGCCTAC AGGTTTGGTGGGAGAAGCGTCCCATGCTATGTCCATATTCTCCTGGCCAGCCTCTACGTT GTCATTCCTCCTATGCTCAATCCCGTTATTTATGGAGTGAGGACTAAGCCAATACTGGAA GGGGCTAAGCAGATGTTTTCAAATCTTGCCAAAGGATCTAAA |
| Conceptual translation |
MNNSDTRIAGCFLTGIPGLEQLHIWLSIPFCIMYITALEGNGILICVILSQAILHEPMYI FLSMLASADVLLSTTTMPKALANLWLGYSLISFDGCLTQMFFIHFLFIHSAVLLAMAFDR YVAICSPLRYVTILTSKVIGKIVTAALSHSFIIMFPSIFLLEHLHYCQINIIAHTFCEHM GIAHLSCSDISINVWYGLAAALLSTGLDIMLITVSYIHILQAVFRLLSQDARSKALSTCG SHICVILLFYVPALFSVFAYRFGGRSVPCYVHILLASLYVVIPPMLNPVIYGVRTKPILE GAKQMFSNLAKGSK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,602,587 | 5,602,586 | Ins(1) | -/G | rs34340459 (DbSNP) | |
| 11 | 5,602,929 | 5,602,929 | NS | A/C | I/L | rs74053516 (DbSNP) |
| 11 | 5,602,773 | 5,602,773 | NS | A/C | I/L | rs61892481 (DbSNP) |
| 11 | 5,602,615 | 5,602,615 | NS | A/G | H/R | rs2341434 (DbSNP) |
| 11 | 5,602,605 | 5,602,605 | NS | A/G | T/A | rs2341433 (DbSNP) |
| 11 | 5,602,275 | 5,602,275 | NS | A/G | T/A | rs1077126 (DbSNP) |
| 11 | 5,602,968 | 5,602,968 | NS | A/G | I/V | rs10769086 (DbSNP) |
| 11 | 5,602,438 | 5,602,438 | NS | A/T | H/L | rs2341432 (DbSNP) |
| 11 | 5,602,790 | 5,602,790 | SYN | A/G | L/L | rs2163946 (DbSNP) |
| 11 | 5,602,928 | 5,602,928 | SYN | C/G | A/A | rs10838375 (DbSNP) |
| 11 | 5,602,679 | 5,602,679 | SYN | C/T | N/N | rs892336 (DbSNP) |
| 11 | 5,581,698 | 5,581,698 | SYN | G/C | A/A | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,045 | 5,581,045 | NS | A/G | T/A | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,208 | 5,581,208 | NS | T/A | L/H | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,699 | 5,581,699 | NS | C/A | L/I | 1000GP (CEU) |
| 11 | 5,581,738 | 5,581,738 | NS | G/A | V/I | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,560 | 5,581,560 | SYN | A/G | L/L | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,449 | 5,581,449 | SYN | T/C | N/N | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,385 | 5,581,385 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,581,375 | 5,581,375 | NS | G/A | A/T | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | T/C | L/P | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | N/N | 1000GP (YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L47P | T57A | R141C | A144V | L275I | V288I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | L | A | R | A | L | I | 54.07 | 0.904 |
| 2 | L | T | R | A | L | I | 30.03 | 0.904 |
| 3 | L | T | R | A | L | V | 11.83 | 0.904 |
| 4 | L | T | R | A | I | I | 2.00 | 0.904 |
| 5 | L | A | C | A | L | I | 0.77 | 0.904 |
| 6 | L | A | R | A | I | I | 0.77 | 0.904 |
| 7 | P | T | R | A | L | I | 0.23 | 0.904 |
| 8 | L | T | R | V | L | I | 0.23 | 0.904 |
| 9 | P | T | R | V | L | I | 0.08 | 0.904 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52B6.aApr07-unspliced | main_exon | 5UTR | chr11 | 5,580,877 | 5,580,940 | + |
| CDS | chr11 | 5,580,940 | 5,581,881 | + | ||
| 3UTR | chr11 | 5,581,881 | 5,581,884 | + | ||