OR52E4 Olfactory Receptor
| Gene Symbol | OR52E41 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | E |
| Pseudogene | No |
| CORP pseudogene probability score | 0.02 (functional) |
| Aliases | OR11-55, HsOR11.3.87, ORL3293 |
| External Ids | HGNC: 15213 GeneBank: AB065817, BK004302, NM_001005165 ORDB: ORL3293 |
| Build #39 labels | OR52E4 |
| Chromosomal location | 11:5,884,293-5,885,228 (+) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52E2 | 68.83% | 308 |
| OR52E3P | 69.71% | 307 |
| OR52E8 | 69.03% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52E4B | 90% | 311 |
| Mouse | Or52e4 | 86% | 312 |
| Rat | Or52e4 | 87% | 312 |
| Cow | OR52E1 | 71% | 312 |
| Orang | OR52E3 | 70% | 307 |
| Horse | OR52E19 | 75% | 312 |
| Chimp | OR52E3 | 70% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136972 |
Sequence information
| Nucleotide sequence |
ATGCCTTCTATCAATGACACCCACTTCTATCCCCCCTTCTTCCTCCTGCTAGGAATACCA GGACTGGACACTTTACATATCTGGATTTCTTTCCCATTCTGTATTGTGTACCTGATTGCC ATTGTGGGGAATATGACCATTCTCTTTGTGATCAAAACTGAACATAGTCTACACCAGCCC ATGTTCTACTTCCTGGCCATGTTGTCTATGATTGATCTGGGTCTGTCCACATCCACTATC CCCAAAATGCTAGGAATCTTCTGGTTCAACCTCCAAGAGATCAGCTTTGGGGGATGCCTT CTTCAGATGTTCTTTATTCACATGTTTACAGGCATGGAGACTGTTCTGTTGGTGGTCATG GCTTATGACCGCTTTGTTGCCATCTGCAACCCTCTCCAGTACACCATGATCCTCACCAAT AAAACCATCAGTATCCTAGCTTCTGTGGTTGTTGGAAGAAATTTAGTTCTTGTAACCCCA TTTGTGTTTCTCATTCTGCGTCTGCCATTCTGTGGGCATAACATCGTACCTCACACATAC TGTGAGCACAGGGGTCTGGCCGGGTTGGCCTGTGCACCCATTAAGATCAACATAATCTAT GGGCTCATGGTGATTTCTTATATTATTGTGGATGTGATCTTAATTGCCTCTTCCTATGTG CTTATCCTTAGAGCTGTTTTTCGCCTTCCCTCTCAAGATGTCCGACTAAAGGCCTTCAAT ACCTGTGGTTCTCATGTCTGTGTTATGCTGTGCTTTTACACACCAGCATTTTTTTCTTTT ATGACACATCGTTTTGGCCAAAACATTCCCCACTATATCCATATTCTTTTGGCTAACCTG TATGTGGTTGTCCCACCTGCCCTTAACCCTGTCATTTATGGAGTCAGGACCAAGCAGATC CGAGAGCAAATTGTGAAAATATTTGTACAGAAAGAA |
| Conceptual translation |
MPSINDTHFYPPFFLLLGIPGLDTLHIWISFPFCIVYLIAIVGNMTILFVIKTEHSLHQP MFYFLAMLSMIDLGLSTSTIPKMLGIFWFNLQEISFGGCLLQMFFIHMFTGMETVLLVVM AYDRFVAICNPLQYTMILTNKTISILASVVVGRNLVLVTPFVFLILRLPFCGHNIVPHTY CEHRGLAGLACAPIKINIIYGLMVISYIIVDVILIASSYVLILRAVFRLPSQDVRLKAFN TCGSHVCVMLCFYTPAFFSFMTHRFGQNIPHYIHILLANLYVVVPPALNPVIYGVRTKQI REQIVKIFVQKE Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,906,205 | 5,906,205 | NS | A/G | H/R | rs4757987 (DbSNP) |
| 11 | 5,906,117 | 5,906,117 | NS | A/G | I/V | rs61876191 (DbSNP) |
| 11 | 5,906,048 | 5,906,048 | NS | A/G | I/V | rs4758168 (DbSNP) |
| 11 | 5,906,291 | 5,906,291 | NS | C/T | L/F | rs11823842 (DbSNP) |
| 11 | 5,906,203 | 5,906,203 | NS | G/T | L/F | rs11823828 (DbSNP) |
| 11 | 5,905,669 | 5,905,669 | NS | G/T | L/F | rs16914094 (DbSNP) |
| 11 | 5,906,073 | 5,906,073 | NS | G/T | R/M | rs4757986 (DbSNP) |
| 11 | 5,906,192 | 5,906,192 | SYN | C/A | R/R | rs1453435 (DbSNP) |
| 11 | 5,906,143 | 5,906,143 | SYN | C/T | Y/Y | rs11823809 (DbSNP) |
| 11 | 5,884,975 | 5,884,975 | NS | G/A | R/H | 1000GP (CEU, CHBJPT) |
| 11 | 5,884,818 | 5,884,818 | NS | G/A | V/I | 1000GP (CEU, CHBJPT) |
| 11 | 5,884,973 | 5,884,973 | NS | T/G | F/L | 1000GP (CEU, CHBJPT) |
| 11 | 5,885,061 | 5,885,061 | NS | T/C | F/L | 1000GP (CEU, CHBJPT) |
| 11 | 5,884,843 | 5,884,843 | NS | G/T | R/M | 1000GP (CEU, CHBJPT) |
| 11 | 5,884,962 | 5,884,962 | SYN | A/C | R/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,884,913 | 5,884,913 | SYN | T/C | Y/Y | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | T/G | F/L | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | Y/Y | 1000GP (YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,868,055 | 6,007,613 | CopyNumber | Variation_2903 (DGV) |
| 11 | 5,730,377 | 5,970,717 | CopyNumber | Variation_3836 (DGV) |
| 11 | 5,885,711 | 5,969,185 | CopyNumber | Variation_8676 (DGV) |
| 11 | 5,885,711 | 5,934,044 | CopyNumber | Variation_8677 (DGV) |
| 11 | 5,899,885 | 5,935,103 | CopyNumber | Variation_9650 (DGV), Variation_48860 (DGV), Variation_53917 (DGV) |
| 11 | 5,899,885 | 5,935,102 | CopyNumber | Variation_29603 (DGV) |
| 11 | 5,883,376 | 5,935,626 | CopyNumber | Variation_30541 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
| 11 | 5,885,709 | 5,935,510 | CopyNumber | Variation_37668 (DGV) |
| 11 | 5,875,867 | 5,935,103 | CopyNumber | Variation_48859 (DGV) |
| 11 | 5,899,885 | 5,959,757 | CopyNumber | Variation_53792 (DGV) |
| 11 | 5,871,831 | 5,935,103 | CopyNumber | Variation_53856 (DGV) |
| 11 | 5,905,423 | 5,908,458 | CopyNumber | #134 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| P12H | I39M | F49L | V176I | R184M | I199V | F257L | T262I | R301Q | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | P | I | F | I | M | I | F | T | R | 43.63 | 0.031 |
| 2 | P | I | F | I | M | I | L | T | R | 35.02 | 0.031 |
| 3 | P | I | F | V | R | I | F | T | R | 17.59 | 0.031 |
| 4 | P | I | L | V | R | I | F | T | R | 1.92 | 0.031 |
| 5 | P | M | F | I | M | I | L | T | R | 0.69 | 0.031 |
| 6 | P | I | F | I | M | I | L | T | Q | 0.31 | 0.031 |
| 7 | P | I | F | I | M | V | F | T | R | 0.23 | 0.031 |
| 8 | H | I | F | V | R | I | F | T | R | 0.15 | 0.031 |
| 9 | P | I | F | I | R | I | L | T | R | 0.15 | 0.031 |
| 10 | P | I | F | V | M | I | F | T | R | 0.08 | 0.031 |
| 11 | P | I | F | I | M | I | F | I | R | 0.08 | 0.031 |
| 12 | P | I | F | I | R | I | F | T | R | 0.08 | 0.031 |
| 13 | P | I | F | V | R | I | L | T | R | 0.08 | 0.031 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52E4.aApr07-unspliced | main_exon | CDS | chr11 | 5,884,293 | 5,885,228 | + |
| 3UTR | chr11 | 5,885,228 | 5,885,231 | + | ||