OR52E8 Olfactory Receptor
| Gene Symbol | OR52E81 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | E |
| Pseudogene | No |
| CORP pseudogene probability score | 0 (functional) |
| Aliases | OR11-54, HsOR11.3.85, ORL3334 |
| External Ids | HGNC: 15217 GeneBank: BK004301, NM_001005168 ORDB: ORL3334 |
| Build #39 labels | OR52E8 |
| Chromosomal location | 11:5,856,752-5,857,690 (-) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52E6 | 89.14% | 313 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52E8C | 89% | 312 |
| Dog | OR52E8D | 87% | 311 |
| Mouse | Or52e8 | 85% | 313 |
| Mouse | Or52e8b | 84% | 313 |
| Rat | Or52e8b | 85% | 313 |
| Rat | Or52e8 | 84% | 312 |
| Cow | OR52E4 | 72% | 309 |
| Orang | OR52E3 | 67% | 306 |
| Horse | OR52E20P | 73% | 310 |
| Chimp | OR52E6 | 89% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG357710 |
| mRNA | BC137041 |
| GNF Atlas2 | gnf1h01945_at |
| GNF Atlas2 | gnf1h10875_s_at |
Sequence information
| Nucleotide sequence |
ATGTCTACGTCTAATCACACCCAGTTCCATCCTTCTTCATTCCTACTGCTGGGTATCCCA GGGCTAGAAGATGTGCACATTTGGATTGGAGTCCCTTTTTTCTTTGTGTATCTTGTTGCA CTCCTGGGAAACACTGCTCTCTTGTTTGTGATCCAGACTGAGCAGAGTCTCCATGAGCCT ATGTACTACTTCCTGGCCATGTTGGATTCCATTGACCTGGGCTTGTCTACAGCCACCATC CCCAAAATGTTGGGCATCTTCTGGTTCAATACCAAAGAAATATCTTTTGGAGGCTGCCTT TCTCACATGTTCTTCATCCATTTCTTCACTGCTATGGAGAGCATTGTGTTGGTGGCCATG GCCTTTGACCGCTACATTGCCATTTGCAAACCTCTTCGGTACACCATGATCCTCACCAGC AAAATCATCAGCCTCATTGCAGGCATTGCTGTCCTGAGGAGCCTGTACATGGTTGTTCCA CTGGTGTTTCTCCTTCTGAGGCTGCCCTTCTGTGGGCATCGTATCATCCCTCATACTTAT TGTGAGCACATGGGCATTGCCCGTCTGGCCTGTGCCAGCATCAAAGTCAACATTAGGTTT GGCCTTGGCAACATATCTCTCTTGTTACTGGATGTTATCCTTATTATTCTCTCCTATGTC AGGATCCTGTATGCTGTCTTCTGCCTGCCCTCCTGGGAAGCTCGACTCAAAGCTCTCAAC ACCTGTGGTTCTCATATTGGTGTTATCTTAGCCTTTTTTACACCAGCATTTTTTTCATTC TTGACACATCGTTTTGGCCATAATATCCCACAGTATATACATATTATATTAGCCAACCTG TATGTGGTTGTCCCACCAGCCCTCAATCCTGTAATCTATGGAGTCAGGACAAAGCAGATT CGAGAGAGAGTGCTGAGGATTTTTCTCAAGACCAATCAC |
| Conceptual translation |
MSTSNHTQFHPSSFLLLGIPGLEDVHIWIGVPFFFVYLVALLGNTALLFVIQTEQSLHEP MYYFLAMLDSIDLGLSTATIPKMLGIFWFNTKEISFGGCLSHMFFIHFFTAMESIVLVAM AFDRYIAICKPLRYTMILTSKIISLIAGIAVLRSLYMVVPLVFLLLRLPFCGHRIIPHTY CEHMGIARLACASIKVNIRFGLGNISLLLLDVILIILSYVRILYAVFCLPSWEARLKALN TCGSHIGVILAFFTPAFFSFLTHRFGHNIPQYIHIILANLYVVVPPALNPVIYGVRTKQI RERVLRIFLKTNH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,878,187 | 5,878,187 | Del(1) | -/T | rs71640255 (DbSNP) | |
| 11 | 5,878,370 | 5,878,369 | Ins(1) | -/C | rs35272168 (DbSNP) | |
| 11 | 5,878,059 | 5,878,059 | NS | A/G | F/L | rs61059077 (DbSNP) |
| 11 | 5,857,606 | 5,857,606 | NS | T/A | I/F | 1000GP (CEU) |
| 11 | 5,857,387 | 5,857,387 | NS | G/A | H/Y | 1000GP (CEU) |
| 11 | 5,856,938 | 5,856,938 | SYN | G/T | A/A | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | C/T | R/Q | 1000GP (YRI, YRI) |
| 11 | 100 | -100 | SYN | C/T | L/L | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,868,055 | 6,007,613 | CopyNumber | Variation_2903 (DGV) |
| 11 | 5,730,377 | 5,970,717 | CopyNumber | Variation_3836 (DGV) |
| 11 | 5,871,630 | 5,883,376 | CopyNumber | Variation_31805 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
| 11 | 5,873,442 | 5,888,004 | CopyNumber | Variation_34990 (DGV) |
| 11 | 5,874,403 | 5,883,432 | CopyNumber | Variation_37480 (DGV) |
| 11 | 5,872,237 | 5,883,317 | CopyNumber | Variation_38003 (DGV) |
| 11 | 5,873,985 | 5,883,493 | CopyNumber | Variation_41251 (DGV) |
| 11 | 5,875,867 | 5,935,103 | CopyNumber | Variation_48859 (DGV) |
| 11 | 5,871,831 | 5,935,103 | CopyNumber | Variation_53856 (DGV) |
| 11 | 5,874,145 | 5,883,464 | CopyNumber | Variation_65853 (DGV) |
| 11 | 5,873,318 | 5,883,937 | CopyNumber | Variation_75533 (DGV) |
| 11 | 5,876,188 | 5,881,370 | CopyNumber | Variation_75534 (DGV) |
| 11 | 5,869,874 | 5,883,937 | CopyNumber | Variation_75535 (DGV), Variation_85632 (DGV) |
| 11 | 5,874,466 | 5,881,370 | CopyNumber | Variation_75536 (DGV) |
| 11 | 5,873,605 | 5,883,937 | CopyNumber | Variation_85633 (DGV) |
| 11 | 5,875,614 | 5,881,928 | CopyNumber | Variation_85634 (DGV) |
| 11 | 5,877,336 | 5,881,370 | CopyNumber | Variation_85635 (DGV) |
| Deletion | 248 (Hasin) | |||
| 11 | 5,875,982 | 5,879,020 | Deletion | #19 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L292F | E186K | H177P | R137Q | F108L | H106Y | G102D | N94D | I33F | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | E | H | R | F | H | G | N | I | 93.63 | 0.009 |
| 2 | L | E | H | R | F | H | G | N | F | 1.77 | 0.009 |
| 3 | F | E | H | R | F | H | G | N | I | 1.15 | 0.009 |
| 4 | L | E | H | R | F | H | G | D | I | 1.00 | 0.009 |
| 5 | L | E | P | R | F | H | G | N | I | 0.92 | 0.009 |
| 6 | L | E | H | Q | F | H | G | N | I | 0.84 | 0.009 |
| 7 | L | E | H | R | F | H | D | N | I | 0.38 | 0.009 |
| 8 | L | E | H | R | F | Y | G | N | F | 0.15 | 0.009 |
| 9 | L | K | H | R | F | H | G | N | I | 0.08 | 0.009 |
| 10 | L | E | H | R | L | H | G | N | I | 0.08 | 0.009 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52E8.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,856,749 | 5,856,752 | - |
| CDS | chr11 | 5,856,752 | 5,857,690 | - | ||
| 5UTR | chr11 | 5,857,690 | 5,857,702 | - | ||