OR52H1 Olfactory Receptor
| Gene Symbol | OR52H11 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-41, OR11-45, HsOR11.3.70, ORL3342 |
| External Ids | HGNC: 15218 GeneBank: AB065802, BK004383, BK004682, NM_001005289 ORDB: ORL3342 |
| Build #39 labels | OR52H1 |
| Chromosomal location | 11:5,544,564-5,545,505 (-) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs1566275) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52H2P | 76.85% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52H1B | 89% | 314 |
| Mouse | Or52h1 | 90% | 310 |
| Rat | Or52h1 | 89% | 310 |
| Cow | OR52H1D | 89% | 314 |
| Orang | OR52H18 | 80% | 308 |
| Horse | OR52H1E | 86% | 314 |
| Chimp | OR52H2P | 72% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136998 |
| GNF Atlas2 | gnf1h05810_at |
Sequence information
| Nucleotide sequence |
ATGATCATTTTCAACCTGAGCAGTTACAATCCAGGACCCTTCATTCTGGTAGGGATCCCA GGCCTGGAGCAATTCCATGTGTGGATTGGAATTCCCTTCTGTATCATCTACATTGTAGCT GTTGTGGGAAACTGCATCCTTCTCTACCTCATTGTGGTGGAGCATAGTCTTCATGAACCC ATGTTCTTCTTTCTCTCCATGCTGGCCATGACTGACCTCATCTTGTCCACAGCTGGTGTG CCTAAAGCACTCAGTATCTTTTGGCTAGGGGCTCGCGAAATCACATTCCCAGGATGCCTT ACACAAATGTTCTTCCTTCACTATAACTTTGTCCTGGATTCAGCCATTCTGATGGCCATG GCATTTGATCACTATGTAGCTATCTGTTCTCCCTTGAGATATACCACCATCTTGACTCCC AAGACCATCATCAAGAGTGCTATGGGCATCTCCTTTCGAAGCTTCTGCATCATCCTGCCA GATGTATTCTTGCTGACATGCCTGCCTTTCTGCAGGACACGCATCATACCCCACACATAC TGTGAGCATATAGGTGTTGCCCAGCTCGCCTGTGCTGATATCTCCATCAACTTCTGGTAT GGCTTTTGTGTTCCCATCATGACGGTCATCTCAGATGTGATTCTCATTGCTGTTTCCTAC GCACACATCCTCTGTGCTGTCTTTGGCCTTCCCTCCCAAGATGCCTGCCAGAAAGCCCTC GGCACTTGTGGTTCTCATGTCTGTGTCATCCTCATGTTTTATACACCTGCCTTTTTCTCC ATCCTCGCCCATCGCTTTGGACACAATGTCTCTCGCACCTTCCACATCATGTTTGCCAAT CTCTACATTGTTATCCCACCTGCACTCAACCCCATGGTTTACGGAGTGAAGACCAAGCAG ATCAGAGATAAGGTTATACTTTTGTTTTCTAAGGGTACAGGA |
| Conceptual translation |
MIIFNLSSYNPGPFILVGIPGLEQFHVWIGIPFCIIYIVAVVGNCILLYLIVVEHSLHEP MFFFLSMLAMTDLILSTAGVPKALSIFWLGAREITFPGCLTQMFFLHYNFVLDSAILMAM AFDHYVAICSPLRYTTILTPKTIIKSAMGISFRSFCIILPDVFLLTCLPFCRTRIIPHTY CEHIGVAQLACADISINFWYGFCVPIMTVISDVILIAVSYAHILCAVFGLPSQDACQKAL GTCGSHVCVILMFYTPAFFSILAHRFGHNVSRTFHIMFANLYIVIPPALNPMVYGVKTKQ IRDKVILLFSKGTG Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | A/G | M/T | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | C/T | T/T | 1000GP (YRI, YRI) |
| 11 | 5,544,676 | 5,544,676 | NS | A/G | M/T | 1000GP (CEU, CHBJPT) |
| 11 | 5,544,800 | 5,544,800 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,544,821 | 5,544,821 | NS | C/A | G/C | 1000GP (CEU, CHBJPT) |
| 11 | 5,544,882 | 5,544,882 | SYN | C/T | T/T | 1000GP (CEU, CHBJPT) |
| 11 | 5,545,135 | 5,545,135 | NS | T/C | H/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,545,259 | 5,545,259 | NS | C/T | A/T | 1000GP (CEU, CHBJPT) |
| 11 | 5,565,906 | 5,565,906 | NS | A/G | M/T | rs7934354 (DbSNP) |
| 11 | 5,566,030 | 5,566,030 | NS | G/A | R/C | rs1995158 (DbSNP) |
| 11 | 5,566,051 | 5,566,051 | NS | C/A | G/C | rs1995157 (DbSNP) |
| 11 | 5,566,112 | 5,566,112 | SYN | T/C | T/T | rs1995156 (DbSNP) |
| 11 | 5,566,227 | 5,566,226 | Ins(1) | -/A | rs35658346 (DbSNP) | |
| 11 | 5,566,365 | 5,566,365 | NS | T/C | H/R | rs1566275 (DbSNP) |
| 11 | 5,566,489 | 5,566,489 | NS | C/T | A/T | rs10769054 (DbSNP) |
| 11 | 5,566,615 | 5,566,615 | NS | C/T | V/I | rs2254076 (DbSNP) |
| 11 | 5,566,620 | 5,566,620 | NS | A/G | V/A | rs56291963 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
| 11 | 5,563,794 | 5,566,835 | Deletion, CopyNumber | #258 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M283T | R278H | G235C | A227V | I182V | H130R | I122V | C105F | A89T | V47I | V45A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | R | C | A | I | R | I | C | T | V | V | 37.25 | 0.614 |
| 2 | M | R | G | A | I | R | I | C | A | V | V | 30.49 | 0.663 |
| 3 | T | R | G | A | I | R | I | C | A | V | V | 14.82 | 0.663 |
| 4 | M | R | G | A | I | H | I | C | A | V | V | 11.90 | 0.663 |
| 5 | M | R | C | A | I | R | I | C | T | V | A | 1.84 | 0.614 |
| 6 | M | R | G | A | I | R | I | F | A | V | V | 1.54 | 0.663 |
| 7 | M | R | G | A | I | R | I | C | T | V | V | 0.46 | 0.663 |
| 8 | M | R | C | A | V | R | I | C | T | V | V | 0.38 | 0.614 |
| 9 | M | R | G | A | I | H | I | C | A | I | V | 0.38 | 0.663 |
| 10 | M | R | G | A | I | H | V | C | A | I | V | 0.31 | 0.663 |
| 11 | M | R | C | V | I | R | I | C | T | V | V | 0.15 | 0.321 |
| 12 | M | H | G | A | I | R | I | C | A | V | V | 0.15 | 0.663 |
| 13 | T | R | G | A | I | H | I | C | A | V | V | 0.15 | 0.663 |
| 14 | M | R | C | A | I | R | I | C | A | V | V | 0.08 | 0.614 |
| 15 | M | R | C | A | I | H | I | C | T | V | V | 0.08 | 0.614 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52H1.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,544,561 | 5,544,564 | - |
| CDS | chr11 | 5,544,564 | 5,545,505 | - | ||
| 5UTR | chr11 | 5,545,505 | 5,545,523 | - | ||