OR52N2 Olfactory Receptor
| Gene Symbol | OR52N21 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | N |
| Pseudogene | No |
| CORP pseudogene probability score | 0.09 (functional) |
| Aliases | OR11-57, HsOR11.3.83, ORL3324 |
| External Ids | HGNC: 15228 GeneBank: AB065816, BK004303, NM_001005174 ORDB: ORL3324 |
| Build #39 labels | OR52N2 |
| Chromosomal location | 11:5,820,336-5,821,298 (+) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52N1 | 76.11% | 314 |
| OR52N3P | 75.16% | 314 |
| OR52N4 | 72.7% | 315 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52N2G | 85% | 314 |
| Mouse | Or52n2 | 89% | 318 |
| Mouse | Or52n2c | 88% | 318 |
| Rat | Or52n2 | 89% | 316 |
| Rat | Or52n2e | 88% | 318 |
| Rat | Or52n2f | 86% | 318 |
| Cow | OR52N2H | 88% | 320 |
| Cow | OR52N2G | 86% | 314 |
| Orang | OR52N2P | 88% | 316 |
| Horse | OR52N4 | 73% | 310 |
| Chimp | OR52N1 | 77% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG328810 |
| mRNA | BC140732 |
| GNF Atlas2 | gnf1h01944_at |
Sequence information
| Nucleotide sequence |
ATGTCTGGGGACAACAGCTCCAGCCTGACCCCAGGATTCTTTATCTTGAATGGCGTTCCT GGGCTGGAAGCCACACACATCTGGATCTCCCTGCCATTCTGCTTTATGTACATCATTGCT GTCGTGGGGAACTGTGGGCTCATCTGCCTCATCAGCCATGAGGAGGCCCTGCACCGGCCC ATGTACTACTTCCTGGCCCTGCTCTCCTTCACTGATGTCACCTTGTGCACCACCATGGTA CCTAATATGCTGTGCATATTCTGGTTCAACCTCAAGGAGATTGACTTTAACGCCTGCCTG GCCCAGATGTTTTTTGTCCATATGCTGACAGGGATGGAGTCTGGGGTGCTCATGCTCATG GCCCTGGACCGCTATGTGGCCATCTGCTACCCCTTACGCTATGCCACCATCCTTACCAAC CCTGTCATCGCCAAGGCTGGTCTTGCCACCTTCTTGAGGAATGTGATGCTCATCATCCCA TTCACTCTCCTCACCAAGCGCCTGCCCTATTGCCGGGGGAACTTCATCCCCCACACCTAC TGTGACCATATGTCTGTGGCCAAGGTATCCTGTGGCAATTTCAAGGTCAATGCTATTTAT GGTCTGATGGTTGCTCTCCTGATTGGTGTGTTTGATATCTGCTGTATCTCTGTATCTTAC ACTATGATTTTGCAGGCTGTTATGAGCCTGTCATCAGCAGATGCTCGTCACAAAGCCTTC AGCACCTGCACATCTCACATGTGTTCCATTGTGATCACCTATGTTGCTGCTTTTTTCACT TTTTTCACTCATCGTTTTGTAGGACACAATATCCCAAACCACATACACATCATCGTGGCC AACCTTTATCTGCTACTGCCTCCTACCATGAACCCAATTGTTTATGGAGTCAAGACCAAG CAGATTCAGGAAGGTGTAATTAAATTTTTACTTGGAGACAAGGTTAGTTTTACCTATGAC AAA |
| Conceptual translation |
MSGDNSSSLTPGFFILNGVPGLEATHIWISLPFCFMYIIAVVGNCGLICLISHEEALHRP MYYFLALLSFTDVTLCTTMVPNMLCIFWFNLKEIDFNACLAQMFFVHMLTGMESGVLMLM ALDRYVAICYPLRYATILTNPVIAKAGLATFLRNVMLIIPFTLLTKRLPYCRGNFIPHTY CDHMSVAKVSCGNFKVNAIYGLMVALLIGVFDICCISVSYTMILQAVMSLSSADARHKAF STCTSHMCSIVITYVAAFFTFFTHRFVGHNIPNHIHIIVANLYLLLPPTMNPIVYGVKTK QIQEGVIKFLLGDKVSFTYDK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,842,356 | 5,842,356 | NS | A/G | H/R | rs8181512 (DbSNP) |
| 11 | 5,841,701 | 5,841,701 | NS | A/G | R/G | rs73394370 (DbSNP) |
| 11 | 5,841,926 | 5,841,926 | NS | A/G | T/A | rs73394377 (DbSNP) |
| 11 | 5,842,283 | 5,842,283 | NS | A/T | I/F | rs61875922 (DbSNP) |
| 11 | 5,842,384 | 5,842,384 | NS | C/G | N/K | rs62621415 (DbSNP) |
| 11 | 5,841,743 | 5,841,743 | NS | C/T | P/S | rs73394373 (DbSNP) |
| 11 | 5,842,310 | 5,842,310 | NS | G/T | A/S | rs8181529 (DbSNP) |
| 11 | 5,842,081 | 5,842,081 | SYN | A/G | R/R | rs73394378 (DbSNP) |
| 11 | 5,841,778 | 5,841,778 | SYN | A/T | T/T | rs73394374 (DbSNP) |
| 11 | 5,841,856 | 5,841,856 | SYN | C/T | N/N | rs4758435 (DbSNP) |
| 11 | 5,821,080 | 5,821,080 | NS | T/G | S/A | 1000GP (CEU, CHBJPT) |
| 11 | 5,821,099 | 5,821,099 | NS | T/G | V/G | 1000GP (CEU) |
| 11 | 5,821,053 | 5,821,053 | NS | T/A | F/I | 1000GP (CEU) |
| 11 | 5,821,154 | 5,821,154 | NS | C/G | N/K | 1000GP (CEU) |
| 11 | 5,820,626 | 5,820,626 | SYN | C/T | N/N | 1000GP (CEU, CHBJPT) |
| 11 | 5,820,471 | 5,820,471 | NS | G/A | G/R | 1000GP (CEU) |
| 11 | 5,821,126 | 5,821,126 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,820,851 | 5,820,851 | SYN | G/A | R/R | 1000GP (CEU) |
| 11 | 5,821,264 | 5,821,264 | NS | T/C | L/S | 1000GP (CEU) |
| 11 | 5,820,696 | 5,820,696 | NS | G/A | A/T | 1000GP (CEU) |
| 11 | 5,820,548 | 5,820,548 | SYN | T/A | T/T | 1000GP (CEU) |
| 11 | 100 | -100 | SYN | T/C | N/N | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | NS | G/A | G/R | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,776,623 | 5,842,356 | CopyNumber | Variation_2902 (DGV) |
| 11 | 5,730,377 | 5,970,717 | CopyNumber | Variation_3836 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
| 11 | 5,841,068 | 5,841,856 | InDel | Variation_48855 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G46R | P60S | A121T | T162N | K238E | F240I | S249A | V255G | H264R | N273K | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | P | A | T | K | F | S | V | H | N | 48.23 | 0.101 |
| 2 | G | P | A | T | K | F | A | V | R | N | 41.94 | 0.183 |
| 3 | G | S | A | T | K | F | A | V | R | N | 3.92 | 0.324 |
| 4 | R | P | T | T | K | F | A | G | H | K | 3.46 | 0.117 |
| 5 | G | P | A | T | E | F | A | V | H | N | 0.84 | 0.081 |
| 6 | G | P | A | N | K | F | A | V | H | N | 0.46 | 0.081 |
| 7 | G | P | A | T | K | F | A | V | H | N | 0.31 | 0.081 |
| 8 | G | P | T | T | K | F | A | G | H | K | 0.15 | 0.117 |
| 9 | G | P | A | T | K | I | S | V | H | N | 0.15 | 0.170 |
| 10 | R | P | T | T | K | F | A | G | H | N | 0.15 | 0.117 |
| 11 | G | P | A | T | K | F | S | V | R | N | 0.15 | 0.222 |
| 12 | G | P | A | N | K | F | A | V | R | N | 0.08 | 0.183 |
| 13 | R | S | T | T | K | F | A | G | H | K | 0.08 | 0.221 |
| 14 | G | S | T | T | K | F | A | G | H | K | 0.08 | 0.221 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52N3PandOR52N2.aApr07 | exon_5UTR | chr11 | 5,801,208 | 5,801,304 | + | |
| exon_5UTR | chr11 | 5,801,590 | 5,801,670 | + | ||
| exon_5UTR | chr11 | 5,803,788 | 5,803,869 | + | ||
| main_exon | 5UTR | chr11 | 5,820,282 | 5,820,336 | + | |
| CDS | chr11 | 5,820,336 | 5,821,298 | + | ||
| 3UTR | chr11 | 5,821,298 | 5,821,301 | + | ||