OR52R1 Olfactory Receptor
| Gene Symbol | OR52R11 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | R |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-22, HsOR11.3.24, ORL3419 |
| External Ids | HGNC: 15235 GeneBank: AB065857, BK004282, NM_001005177 ORDB: ORL3419 |
| Build #39 labels | OR52R1 |
| Chromosomal location | 11:4,803,436-4,804,380 (-) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs7941731) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52L1 | 57.47% | 308 |
| OR52L2P | 55.84% | 308 |
| OR52N4 | 54.79% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52R1D | 81% | 314 |
| Mouse | Or52r1c | 82% | 311 |
| Mouse | Or52r1 | 82% | 308 |
| Mouse | Or52r1b | 81% | 313 |
| Rat | Or52r1c | 82% | 313 |
| Rat | Or52r1 | 81% | 308 |
| Cow | OR52R1E | 81% | 310 |
| Cow | OR52R1FP | 80% | 307 |
| Orang | OR52L2 | 57% | 311 |
| Horse | OR52R1H | 83% | 314 |
| Horse | OR52R1G | 83% | 314 |
| Chimp | OR52E3 | 56% | 301 |
Sequence information
| Nucleotide sequence |
ATGGTGCTGGCTTCAGGGAACAGCTCTTCTCATCCTGTGTCCTTCATCCTGCTTGGAATC CCAGGCCTGGAGAGTTTCCAGTTGTGGATTGCCTTTCCGTTCTGTGCCACGTATGCTGTG GCTGTTGTTGGAAATATCACTCTCCTCCATGTAATCAGAATTGACCACACCCTGCATGAG CCCATGTACCTCTTTCTGGCCATGCTGGCCATCACTGACCTGGTCCTCTCCTCCTCCACT CAACCTAAGATGTTGGCCATATTCTGGTTTCATGCTCATGAGATTCAGTACCATGCCTGC CTCATCCAGGTGTTCTTCATCCATGCCTTTTCTTCTGTGGAGTCTGGGGTGCTCATGGCT ATGGCCCTGGACTGCTACGTGGCTATCTGCTTCCCACTCCGACACTCTAGCATCCTGACC CCATCGGTCGTGATCAAACTGGGGACCATCGTGATGCTGAGAGGGCTGCTGTGGGTGAGC CCCTTCTGCTTCATGGTGTCTAGGATGCCCTTCTGCCAACACCAAGCCATTCCCCAGTCA TACTGTGAGCACATGGCTGTGCTGAAGTTGGTGTGTGCTGATACAAGCATAAGTCGTGGG AATGGGCTCTTTGTGGCCTTCTCTGTGGCTGGCTTTGATATGATTGTCATTGGTATGTCA TACGTGATGATTTTGAGAGCTGTGCTTCAGTTGCCCTCAGGTGAAGCCCGCCTCAAAGCT TTTAGCACACGTTCCTCCCATATCTGTGTCATCTTGGCTCTTTATATCCCAGCCCTTTTT TCTTTCCTCACCTACCGCTTTGGCCATGATGTGCCCCGAGTTGTACACATCCTGTTTGCT AATCTCTATCTACTGATACCTCCCATGCTCAACCCCATCATTTATGGAGTTAGAACCAAA CAGATCGGGGACAGGGTTATCCAAGGATGTTGTGGAAACATCCCC |
| Conceptual translation |
MVLASGNSSSHPVSFILLGIPGLESFQLWIAFPFCATYAVAVVGNITLLHVIRIDHTLHE PMYLFLAMLAITDLVLSSSTQPKMLAIFWFHAHEIQYHACLIQVFFIHAFSSVESGVLMA MALDCYVAICFPLRHSSILTPSVVIKLGTIVMLRGLLWVSPFCFMVSRMPFCQHQAIPQS YCEHMAVLKLVCADTSISRGNGLFVAFSVAGFDMIVIGMSYVMILRAVLQLPSGEARLKA FSTRSSHICVILALYIPALFSFLTYRFGHDVPRVVHILFANLYLLIPPMLNPIIYGVRTK QIGDRVIQGCCGNIP Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 4,825,349 | 4,825,349 | NS | A/G | F/L | rs17327254 (DbSNP) |
| 11 | 4,825,225 | 4,825,225 | NS | A/G | I/T | rs7941731 (DbSNP) |
| 11 | 4,825,010 | 4,825,010 | NS | A/T | Y/N | rs6578533 (DbSNP) |
| 11 | 4,824,878 | 4,824,878 | NS | C/A | A/S | rs2053116 (DbSNP) |
| 11 | 4,825,530 | 4,825,530 | NS | C/A | Q/H | rs61746977 (DbSNP) |
| 11 | 4,825,022 | 4,825,022 | NS | C/T | V/I | rs73403015 (DbSNP) |
| 11 | 4,825,421 | 4,825,421 | NS | G/A | L/F | rs61740077 (DbSNP) |
| 11 | 4,825,426 | 4,825,426 | NS | G/A | T/M | rs61746698 (DbSNP) |
| 11 | 4,824,752 | 4,824,752 | NS | T/G | T/P | rs61742567 (DbSNP) |
| 11 | 4,825,566 | 4,825,566 | SYN | G/A | F/F | rs61744541 (DbSNP) |
| 11 | 4,803,648 | 4,803,648 | NS | A/C | S/A | 1000GP (CEU, CHBJPT) |
| 11 | 4,804,336 | 4,804,336 | SYN | G/A | F/F | 1000GP (CEU) |
| 11 | 4,804,119 | 4,804,119 | NS | A/G | F/L | 1000GP (CEU) |
| 11 | 4,804,297 | 4,804,297 | SYN | C/T | L/L | 1000GP (CEU) |
| 11 | 4,803,995 | 4,803,995 | NS | A/G | I/T | 1000GP (CEU, CHBJPT) |
| 11 | 4,803,780 | 4,803,780 | NS | T/A | N/Y | 1000GP (CEU) |
| 11 | 100 | -100 | NS | G/T | P/T | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 87 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| P287T | S245A | N201Y | I197V | I129T | F88L | L64F | E60K | Q27H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | P | S | N | I | I | F | L | E | Q | 64.82 | 0.900 |
| 2 | P | A | Y | I | T | F | L | E | Q | 27.80 | 0.989 |
| 3 | P | A | Y | I | T | L | L | E | Q | 4.38 | 0.989 |
| 4 | P | S | N | I | I | F | F | E | Q | 1.77 | 0.900 |
| 5 | P | A | Y | V | T | F | L | K | Q | 0.31 | 0.989 |
| 6 | P | S | Y | I | T | F | L | E | Q | 0.31 | 0.989 |
| 7 | T | S | N | I | I | F | L | E | Q | 0.23 | 0.900 |
| 8 | P | A | Y | I | T | L | L | E | H | 0.15 | 0.989 |
| 9 | P | S | N | V | I | F | L | E | Q | 0.15 | 0.900 |
| 10 | P | A | Y | I | I | F | L | E | Q | 0.08 | 0.900 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52R1.aApr07-unspliced | main_exon | 3UTR | chr11 | 4,803,433 | 4,803,436 | - |
| CDS | chr11 | 4,803,436 | 4,804,380 | - | ||
| 5UTR | chr11 | 4,804,380 | 4,804,617 | - | ||