OR5AK2 Olfactory Receptor
| Gene Symbol | OR5AK21 (View this gene in GeneCards) |
| Family | 5 |
| Subfamily | AK |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | HsOR11.11.96, ORL3454 |
| External Ids | HGNC: 15251 GeneBank: AB065496, NM_001005323 ORDB: ORL3454 |
| Build #39 labels | OR5AK2 |
| Chromosomal location | 11:56,988,914-56,989,840 (+) |
| Cluster | 11@57 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR5AK1P | 89.64% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR5AK7 | 78% | 309 |
| Mouse | Or5ak23 | 76% | 305 |
| Rat | Or5ak25 | 76% | 307 |
| Cow | OR5AK7 | 79% | 307 |
| Orang | OR5AK1 | 92% | 309 |
| Horse | OR5AK35 | 77% | 309 |
| Chimp | OR5AK1P | 90% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BU102162 |
| mRNA | BC137198 |
| GNF Atlas2 | gnf1h10679_at |
Sequence information
| Nucleotide sequence |
ATGACACTAGGAAACAGCACTGAAGTCACTGAATTCTATCTTCTGGGATTTGGTGCCCAG CATGAGTTTTGGTGTATCCTCTTCATTGTATTCCTTCTCATCTATGTGACCTCCATAATG GGTAATAGTGGAATAATCTTACTCATCAACACAGATTCCAGATTTCAAACACTCACGTAC TTTTTTCTACAACATTTGGCTTTTGTTGATATCTGTTACACTTCTGCTATCACTCCCAAG ATGCTCCAAAGCTTCACAGAAGAAAAGAATTTGATGTTATTTCAGGGCTGTGTGATACAA TTCTTAGTTTATGCAACATTTGCAACCAGTGACTGTTATCTCCTGGCTATGATGGCAGTG GATCCTTATGTTGCCATCTGTAAGCCCCTTCACTATACTGTAATCATGTCCCGAACAGTC TGCATCCGTTTGGTAGCTGGTTCATACATCATGGGCTCAATAAATGCCTCTGTACAAACA GGTTTTACATGTTCACTGTCCTTCTGCAAGTCCAATAGCATCAATCACTTTTTCTGTGAT GTTCCCCCTATTCTTGCTCTTTCATGCTCCAATGTTGACATCAACATCATGCTACTTGTT GTCTTTGTGGGATCTAACTTGATATTCACTGGGTTGGTCGTCATCTTTTCCTACATCTAC ATCATGGCCACCATCCTGAAAATGTCTTCTAGTGCAGGAAGGAAAAAATCCTTCTCAACA TGTGCTTCCCACCTGACCGCAGTCACCATTTTCTATGGGACACTCTCTTACATGTATTTG CAGTCTCATTCTAATAATTCCCAGGAAAATATGAAAGTGGCCTTTATATTTTATGGCACA GTTATTCCCATGTTAAATCCTTTAATCTATAGCTTGAGAAATAAGGAAGTAAAAGAAGCT TTAAAAGTGATAGGGAAAAAGTTATTT |
| Conceptual translation |
MTLGNSTEVTEFYLLGFGAQHEFWCILFIVFLLIYVTSIMGNSGIILLINTDSRFQTLTY FFLQHLAFVDICYTSAITPKMLQSFTEEKNLMLFQGCVIQFLVYATFATSDCYLLAMMAV DPYVAICKPLHYTVIMSRTVCIRLVAGSYIMGSINASVQTGFTCSLSFCKSNSINHFFCD VPPILALSCSNVDINIMLLVVFVGSNLIFTGLVVIFSYIYIMATILKMSSSAGRKKSFST CASHLTAVTIFYGTLSYMYLQSHSNNSQENMKVAFIFYGTVIPMLNPLIYSLRNKEVKEA LKVIGKKLF Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 56,756,398 | 56,756,398 | nonsense SNP | G/T | G/* | rs13343184 (DbSNP) |
| 11 | 56,756,915 | 56,756,915 | NS | A/G | H/R | rs62001000 (DbSNP) |
| 11 | 56,756,664 | 56,756,664 | NS | A/G | I/M | rs2853083 (DbSNP) |
| 11 | 56,756,516 | 56,756,516 | NS | C/G | T/S | rs12420424 (DbSNP) |
| 11 | 56,756,399 | 56,756,399 | NS | G/T | G/V | rs10896563 (DbSNP) |
| 11 | 56,756,565 | 56,756,565 | SYN | A/G | T/T | rs62001001 (DbSNP) |
| 11 | 56,757,021 | 56,757,021 | SYN | A/G | G/G | rs61886711 (DbSNP) |
| 11 | 56,989,546 | 56,989,546 | SYN | G/A | G/G | 1000GP (CEU, CHBJPT) |
| 11 | 56,989,189 | 56,989,189 | NS | G/A | M/I | 1000GP (CEU, CHBJPT) |
| 11 | 56,988,924 | 56,988,924 | NS | G/T | G/V | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | G/T | G/V | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | T/T | 1000GP (YRI, YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G4V | S43T | M92I | H176R | V214I | K306T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | G | S | I | H | V | K | 52.46 | 0.998 |
| 2 | G | S | M | H | V | K | 27.11 | 0.999 |
| 3 | V | S | I | H | V | K | 13.82 | 0.998 |
| 4 | G | T | I | H | V | K | 4.15 | 0.998 |
| 5 | G | S | I | R | V | K | 1.84 | 0.998 |
| 6 | G | S | I | H | I | K | 0.31 | 0.998 |
| 7 | G | S | I | H | V | T | 0.15 | 0.998 |
| 8 | V | T | I | H | V | K | 0.08 | 0.998 |
| 9 | G | S | M | R | V | K | 0.08 | 0.999 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5AK2.aApr07-unspliced | main_exon | CDS | chr11 | 56,988,914 | 56,989,840 | + |
| 3UTR | chr11 | 56,989,840 | 56,989,843 | + | ||