OR5AR1 Olfactory Receptor
| Gene Symbol | OR5AR11 (View this gene in GeneCards) |
| Family | 5 |
| Subfamily | AR |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OR11-209, HsOR11.11.85, ORL3399 |
| External Ids | HGNC: 15260 GeneBank: AB065740, BK004401, NM_001004730 ORDB: ORL3399 |
| Build #39 labels | OR5AR1 |
| Chromosomal location | 11:56,663,686-56,664,615 (+) |
| Cluster | 11@56 |
| Synteny | CLIC#26 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs11228710 (AA change=Q/* ) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR5B12 | 58.55% | 304 |
| OR5B21 | 59.54% | 304 |
| OR5W2 | 56.68% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR5W2B | 60% | 308 |
| Mouse | Or5ar1 | 93% | 310 |
| Rat | Or5ar1 | 93% | 310 |
| Cow | OR8U3 | 57% | 310 |
| Orang | OR5AU1 | 54% | 309 |
| Horse | OR5AR3P | 77% | 303 |
| Chimp | OR5B12P | 58% | 305 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140745 |
| GNF Atlas2 | gnf1h11093_at |
Sequence information
| Nucleotide sequence |
ATGGATAAAGAAAACAGCTCAATGGTGACTGAGTTTATCTTCATGGGCATCACCCAGGAC CCTCAGATGGAGATCATCTTCTTCGTGGTCTTCCTCATAGTTTACCTGGTTAATGTAGTG GGGAATATTGGTATGATTATCCTGATTACAACAGACACTCAGCTTCACACACCCATGTAT TTTTTCCTCTGCAACCTCTCCTTTGTTGACCTGGGCTACTCCTCAGCCATTGCCCCCAGG ATGCTGGCTGACTTCCTAACAAATCACAAAGTTATCTCCTTCTCCAGCTGTGCCACCCAG TTTGCTTTTTTTGTAGGTTTTGTGGATGCTGAGTGCTATGTCCTGGCAGCCATGGCCTAT GGTCGTTTTGTGGCCATTTGTCGACCCCTCCACTATAGCACCTTCATGTCCAAGCAGGTC TGCTTGGCTCTCATGCTGGGCTCTTACCTGGCTGGTCTAGTGAGTTTAGTAGCCCACACT ACCCTCACCTTCAGCCTGAGTTACTGTGGTTCCAATATCATCAATCATTTCTTCTGCGAA ATCCCACCACTCTTGGCCCTCTCTTGCTCAGACACCTACATCAGTGAGATCTTGCTCTTC AGTCTGTGTGGCTTCATTGAATTCAGCACCATCCTCATCATCTTCATCTCCTATACCTTT ATCCTTGTTGCAATCATCAGAATGCGTTCAGCTGAAGGCCGCCTTAAGGCTTTCTCCACC TGCGGGTCTCACCTTACTGGCATCACCCTCTTCTATGGCACAGTCATGTTTATGTACCTG AGGCCAACATCCAGCTACTCCCTGGACCAAGACAAGTGGGCCTCTGTGTTCTACACGGTT ATCATCCCCATGTTAAATCCCTTGATCTACAGTTTGCGGAACAAGGATGTGAAAGCTGCT TTCAAAAAGCTAATTGGAAAAAAATCTCAA |
| Conceptual translation |
MDKENSSMVTEFIFMGITQDPQMEIIFFVVFLIVYLVNVVGNIGMIILITTDTQLHTPMY FFLCNLSFVDLGYSSAIAPRMLADFLTNHKVISFSSCATQFAFFVGFVDAECYVLAAMAY GRFVAICRPLHYSTFMSKQVCLALMLGSYLAGLVSLVAHTTLTFSLSYCGSNIINHFFCE IPPLLALSCSDTYISEILLFSLCGFIEFSTILIIFISYTFILVAIIRMRSAEGRLKAFST CGSHLTGITLFYGTVMFMYLRPTSSYSLDQDKWASVFYTVIIPMLNPLIYSLRNKDVKAA FKKLIGKKSQ Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 56,431,216 | 56,431,216 | nonsense SNP | C/T | Q/* | rs11228710 (DbSNP) |
| 11 | 56,431,834 | 56,431,834 | NS | A/G | I/V | rs56067375 (DbSNP) |
| 11 | 56,432,093 | 56,432,093 | NS | A/T | "*/L,stop loss" | rs61740352 (DbSNP) |
| 11 | 56,431,998 | 56,431,998 | SYN | A/G | T/T | rs61742850 (DbSNP) |
| 11 | 56,663,740 | 56,663,740 | nonsense SNP | C/T | Q/* | 1000GP (CEU, CHBJPT) |
| 11 | 56,664,021 | 56,664,021 | SYN | C/T | C/C | 1000GP (CEU) |
| 11 | 56,664,142 | 56,664,142 | SYN | C/T | L/L | 1000GP (CEU) |
| 11 | 56,663,911 | 56,663,911 | NS | G/A | A/T | 1000GP (CEU) |
| 11 | 56,664,358 | 56,664,358 | NS | A/G | I/V | 1000GP (CEU, CHBJPT) |
| 11 | 56,664,065 | 56,664,065 | NS | G/T | C/F | 1000GP (CHBJPT) |
| 11 | 56,664,191 | 56,664,191 | NS | G/A | C/Y | 1000GP (CHBJPT) |
| 11 | 56,664,432 | 56,664,432 | SYN | C/T | T/T | 1000GP (CHBJPT) |
| 11 | 100 | -100 | nonsense SNP | C/T | Q/* | 1000GP (YRI) |
| 11 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | T/T | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Q19* | C169Y | I225V | R293W | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | * | C | I | R | 58.53 | 1.200 |
| 2 | Q | C | I | R | 34.10 | 1.000 |
| 3 | Q | C | V | R | 3.99 | 1.000 |
| 4 | * | Y | I | R | 3.15 | 1.200 |
| 5 | * | C | V | R | 0.08 | 1.200 |
| 6 | Q | C | I | W | 0.08 | 1.000 |
| 7 | Q | Y | I | R | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5AR1.aApr07-unspliced | main_exon | CDS | chr11 | 56,663,686 | 56,664,615 | + |
| 3UTR | chr11 | 56,664,615 | 56,664,618 | + | ||