OR5B2 Olfactory Receptor
| Gene Symbol | OR5B21 (View this gene in GeneCards) |
| Family | 5 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | OR11-240, OST073, HsOR11.12.21, ORL3451 |
| External Ids | HGNC: 8323 GeneBank: AB065852, AF399636, BK004505, NM_001005566 ORDB: ORL3451 |
| Build #39 labels | OR5B2 |
| Chromosomal location | 11:58,422,335-58,423,261 (-) |
| Cluster | 11@58 |
| Synteny | CLIC#27 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR5B12 | 73.29% | 307 |
| OR5B1P | 75.9% | 307 |
| OR5B3 | 77.2% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR5B2B | 80% | 307 |
| Mouse | Or5b3 | 76% | 307 |
| Rat | Or5b99 | 74% | 306 |
| Cow | OR5B141 | 78% | 308 |
| Orang | OR5B2P | 96% | 294 |
| Horse | OR5B3 | 79% | 307 |
| Chimp | OR5B3 | 78% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136923 |
Sequence information
| Nucleotide sequence |
ATGGAGAATTGTACGGAAGTGACAAAGTTCATTCTTCTAGGACTAACCAGTGTCCCAGAA CTACAGATCCCCCTCTTTATCTTGTTCACCTTCATCTACCTCCTCACTCTGTGTGGGAAC CTGGGGATGATGTTGCTGATCCTGATGGACTCTTGTCTCCACACCCCCATGTACTTTTTC CTCAGTAACCTGTCTCTGGTGGACTTTGGATACTCCTCAGCTGTCACTCCCAAGGTCATG GCTGGGTTCCTTAGAGGAGACAAGGTCATCTCCTACAATGCATGTGCTGTTCAGATGTTC TTCTTTGTAGCCTTGGCCACGGTGGAAAATTACTTGTTGGCCTCAATGGCCTATGACCGC TATGCAGCAGTGTGCAAACCCCTACACTACACCACCACCATGACGGCCAGTGTAGGTGCC TGTCTGGCCCTAGGCTCATATGTCTGTGGCTTCCTAAATGCCTCATTCCACATTGGGGGC ATATTCAGTCTCTCTTTCTGTAAATCCAATCTGGTACATCACTTTTTCTGTGATGTTCCA GCAGTCATGGCTCTGTCTTGCTCTGATAAACACACTAGTGAGGTGATTCTGGTTTTTATG TCAAGCTTTAATATCTTTTTTGTTCTTCTAGTTATCTTTATCTCCTACTTGTTCATATTC ATCACCATCTTGAAGATGCATTCAGCTAAGGGACACCAAAAAGCATTGTCCACCTGTGCC TCTCACTTCACTGCAGTCTCCGTCTTCTATGGGACAGTAATCTTCATCTACTTGCAGCCC AGCTCCAGCCACTCCATGGACACAGACAAAATGGCATCTGTGTTCTATGCTATGATCATC CCCATGCTGAACCCTGTGGTCTACAGCCTGAGGAACAGAGAAGTCCAGAATGCATTCAAG AAAGTGTTGAGAAGGCAAAAATTTCTA |
| Conceptual translation |
MENCTEVTKFILLGLTSVPELQIPLFILFTFIYLLTLCGNLGMMLLILMDSCLHTPMYFF LSNLSLVDFGYSSAVTPKVMAGFLRGDKVISYNACAVQMFFFVALATVENYLLASMAYDR YAAVCKPLHYTTTMTASVGACLALGSYVCGFLNASFHIGGIFSLSFCKSNLVHHFFCDVP AVMALSCSDKHTSEVILVFMSSFNIFFVLLVIFISYLFIFITILKMHSAKGHQKALSTCA SHFTAVSVFYGTVIFIYLQPSSSHSMDTDKMASVFYAMIIPMLNPVVYSLRNREVQNAFK KVLRRQKFL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 58,190,354 | 58,190,353 | Ins(1) | -/G | rs71977119 (DbSNP) | |
| 11 | 58,190,136 | 58,190,136 | NS | A/G | M/T | rs4298923 (DbSNP) |
| 11 | 58,190,112 | 58,190,112 | NS | A/G | V/A | rs10466659 (DbSNP) |
| 11 | 58,190,414 | 58,190,414 | SYN | C/T | T/T | rs73485945 (DbSNP) |
| 11 | 58,422,639 | 58,422,639 | NS | A/G | V/A | 1000GP (CEU, CHBJPT) |
| 11 | 58,422,663 | 58,422,663 | NS | A/G | M/T | 1000GP (CEU, CHBJPT) |
| 11 | 58,422,942 | 58,422,942 | NS | G/A | T/M | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | A/G | V/A | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | S/S | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 191 (Hasin) | |||
| 11 | 58,187,808 | 58,190,834 | CopyNumber | #76 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V208A | M200T | T192S | T107M | L53I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|
| 1 | V | M | T | T | L | 52.30 | 0.023 |
| 2 | A | T | T | T | L | 21.35 | 0.050 |
| 3 | V | T | T | T | L | 20.66 | 0.023 |
| 4 | V | T | T | T | I | 4.53 | 0.111 |
| 5 | V | T | T | M | L | 0.69 | 0.023 |
| 6 | V | T | S | T | L | 0.46 | 0.023 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5B2.aApr07-unspliced | main_exon | 3UTR | chr11 | 58,422,332 | 58,422,335 | - |
| CDS | chr11 | 58,422,335 | 58,423,261 | - | ||