OR5D18 Olfactory Receptor

Gene Symbol	OR5D18¹ (View this gene in GeneCards)
Family	5
Subfamily	D
Pseudogene	No
CORP pseudogene probability score
Aliases	OR11-143, OR11-152, HsOR11.11.29, ORL3394, ORL3395
External Ids	HGNC: 15285 GeneBank: AB065781, AF399525, BK004329, BK004395, NM_001001952 ORDB: ORL3394, ORL3395
Build #39 labels	OR5D18
Chromosomal location	11:55,819,630-55,820,568 (+)
Cluster	11@56
Synteny	CLIC#26
Remarks

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR5D16	80.77%	312

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR5D14	72%	306
Mouse	Or5d18	82%	312
Mouse	Or5d16	81%	313
Rat	Or5d18	82%	312
Rat	Or5d16-ps	80%	313
Cow	OR5D76P	77%	312
Orang	OR9S18	55%	296
Horse	OR5D18C	83%	313
Horse	OR5D18D	82%	309
Horse	OR5D18EP	84%	301
Horse	OR5D18B	82%	309
Chimp	OR5D16P	80%	312

Expression evidences

Source	Accession
mRNA	BC136925

Sequence information

Nucleotide sequence

ATGCTGCTGACTGATAGAAATACAAGTGGGACCACGTTCACCCTCTTGGGCTTCTCAGAT
TACCCAGAACTGCAAGTCCCACTCTTCCTGGTTTTTCTGGCCATCTACAATGTCACTGTG
CTAGGGAATATTGGGTTGATTGTGATCATCAAAATCAACCCCAAACTGCATACCCCCATG
TACTTTTTCCTCAGCCAACTCTCCTTTGTGGATTTCTGCTATTCCTCCATCATTGCTCCC
AAGATGTTGGTGAACCTTGTTGTCAAAGACAGAACCATTTCATTTTTAGGATGCGTAGTA
CAATTCTTTTTCTTCTGTACCTTTGTGGTCACTGAATCCTTTTTATTAGCTGTGATGGCC
TATGACCGCTTCGTGGCCATTTGCAACCCTCTGCTCTACACAGTTAACATGTCCCAGAAA
CTCTGCGTGCTGCTGGTTGTGGGATCCTATGCCTGGGGAGTCTCATGTTCCTTGGAACTG
ACGTGCTCTGCTTTAAAGTTATGTTTTCATGGTTTCAACACAATCAATCACTTCTTCTGT
GAGTTCTCCTCACTACTCTCCCTTTCTTGCTCTGATACTTACATCAACCAGTGGCTGCTA
TTCTTTCTTGCCACCTTTAATGAAATCAGCACACTACTCATCGTTCTCACATCTTATGCG
TTCATTGTTGTAACCATCCTCAAGATGCGTTCAGTCAGTGGGCGCCGCAAAGCCTTCTCC
ACCTGTGCCTCCCACCTGACTGCCATCACCATCTTCCATGGCACCATCCTCTTCCTTTAC
TGTGTGCCCAACTCCAAAAACTCCAGGCACACAGTCAAAGTGGCCTCTGTGTTTTACACC
GTGGTGATCCCCATGTTGAATCCCCTGATCTACAGTCTGAGAAATAAAGATGTCAAGGAT
ACAGTCACCGAGATACTGGACACCAAAGTCTTCTCTTAC

Conceptual translation

MLLTDRNTSGTTFTLLGFSDYPELQVPLFLVFLAIYNVTVLGNIGLIVIIKINPKLHTPM
YFFLSQLSFVDFCYSSIIAPKMLVNLVVKDRTISFLGCVVQFFFFCTFVVTESFLLAVMA
YDRFVAICNPLLYTVNMSQKLCVLLVVGSYAWGVSCSLELTCSALKLCFHGFNTINHFFC
EFSSLLSLSCSDTYINQWLLFFLATFNEISTLLIVLTSYAFIVVTILKMRSVSGRRKAFS
TCASHLTAITIFHGTILFLYCVPNSKNSRHTVKVASVFYTVVIPMLNPLIYSLRNKDVKD
TVTEILDTKVFSY

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
11	55,587,914	55,587,914	NS	A/G	H/R	rs55832853 (DbSNP)
11	55,587,212	55,587,212	NS	A/G	Y/C	rs7948629 (DbSNP)
11	55,587,457	55,587,457	NS	A/G	M/V	rs11231180 (DbSNP)
11	55,587,827	55,587,827	NS	C/T	T/I	rs55843616 (DbSNP)
11	55,587,587	55,587,587	NS	C/T	T/M	rs62001009 (DbSNP)
11	55,587,511	55,587,511	NS	G/A	D/N	rs297081 (DbSNP)
11	55,587,117	55,587,117	SYN	A/T	T/T	rs297082 (DbSNP)
11	55,587,120	55,587,120	SYN	C/T	D/D	rs62001011 (DbSNP)
11	55,819,736	55,819,736	NS	A/G	Y/C	1000GP (CEU)
11	55,820,035	55,820,035	NS	A/G	N/D	1000GP (CEU, CHBJPT)
11	55,819,728	55,819,728	SYN	G/T	L/L	1000GP (CEU)
11	55,820,438	55,820,438	NS	A/G	H/R	1000GP (CEU, CHBJPT)
11	55,819,641	55,819,641	SYN	T/A	T/T	1000GP (CEU)
11	55,819,981	55,819,981	NS	G/A	V/M	1000GP (CHBJPT)
11	100	-100	SYN	T/A	T/T	1000GP (YRI, YRI)
11	100	-100	NS	A/G	N/D	1000GP (YRI, YRI)

Variations - CNVs

Chr	Start	End	Type	Sources
11	55,153,930	55,816,828	CopyNumber	Variation_0308 (DGV)
11	55,446,295	55,618,623	CopyNumber	Variation_2167 (DGV)
11	55,339,702	55,638,112	CopyNumber	Variation_2926 (DGV)
11	55,222,420	55,621,884	CopyNumber	Variation_3852 (DGV)
11	54,835,623	55,879,426	CopyNumber	Variation_8690 (DGV)
11	55,445,294	55,620,699	CopyNumber	Variation_9187 (DGV)
11	55,377,006	55,620,699	CopyNumber	Variation_9188 (DGV)
11	55,422,586	55,596,313	CopyNumber	Variation_10360 (DGV)
11	55,422,585	55,596,313	CopyNumber	Variation_29911 (DGV)
11	55,437,126	55,596,313	CopyNumber	Variation_48840 (DGV)
11	55,442,368	55,596,313	CopyNumber	Variation_48841 (DGV)
11	55,444,868	55,591,047	CopyNumber	Variation_48842 (DGV)
11	55,444,868	55,596,313	CopyNumber	Variation_48843 (DGV)
11	55,447,427	55,596,313	CopyNumber	Variation_53429 (DGV)
11	55,422,345	55,603,590	CopyNumber	Variation_65956 (DGV)
11	55,560,070	55,602,798	CopyNumber	Variation_85785 (DGV)
11	55,587,006	55,590,044	Deletion	#291 (Waszak)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	Y36C	V118M	N136D	T161M	V215I	R230S	H270R	% Freq	CORP
1	Y	V	D	T	V	R	H	69.20	0.040
2	Y	V	D	T	V	R	R	24.96	0.040
3	C	V	D	T	V	R	H	2.69	0.126
4	Y	M	D	T	V	R	H	1.77	0.040
5	Y	V	D	M	V	R	H	0.38	0.040
6	Y	V	N	T	V	R	H	0.38	0.040
7	Y	V	D	T	I	R	R	0.38	0.040
8	C	V	D	T	V	R	R	0.15	0.126
9	Y	V	D	T	V	S	H	0.08	0.040

AceView Gene Models

The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.

Accession	Type		Chr	Start	End	Strand
OR5D18.aApr07-unspliced	main_exon	CDS	chr11	55,819,630	55,820,568	+
OR5D18.aApr07-unspliced	main_exon	3UTR	chr11	55,820,568	55,820,571	+

HORDE

Search Olfactory receptors

Select ORs from