OR5H2 Olfactory Receptor
| Gene Symbol | OR5H21 (View this gene in GeneCards) |
| Family | 5 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | OR3-10, HsOR3.3.12, ORL3093 |
| External Ids | HGNC: 14752 GeneBank: AB065666, BK004375, NM_001005482 ORDB: ORL3093 |
| Build #39 labels | OR5H2 |
| Chromosomal location | 3:98,282,903-98,283,829 (+) |
| Cluster | 3@98 |
| Synteny | CLIC#9 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR5H1 | 79.61% | 309 |
| OR5H15 | 78.64% | 309 |
| OR5H8P | 81.55% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR5H13 | 79% | 309 |
| Mouse | Or5h18 | 77% | 309 |
| Rat | Or5h18 | 78% | 309 |
| Cow | OR5H13 | 78% | 308 |
| Orang | OR5H8 | 80% | 309 |
| Orang | OR5H8BP | 81% | 257 |
| Horse | OR5H40 | 82% | 309 |
| Chimp | OR5H2P | 98% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BU565715 |
| mRNA | BC104637 |
| GNF Atlas2 | gnf1h01993_at |
Sequence information
| Nucleotide sequence |
ATGGAACAGGATAATACAACATTGCTGACAGAGTTTGTTCTCACAGGACTTACATATCAG CCAGAGTGGAAAATGCCCCTGTTCTTGGTGTTCTTGGTGATCTATCTCATCACTATTGTG TGGAACCTTGGTCTGATTGCTCTTATCTGGAATGACCCACAACTTCACATCCCCATGTAC TTTTTTCTTGGGAGTTTAGCCTTTGTTGATGCTTGGATATCTTCCACAGTAACTCCCAAA ATGTTGGTTAATTTCTTGGCCAAAAACAGGATGATATCTCTGTCTGAATGCATGATTCAA TTTTTTTCCTTTGCATTTGGTGGAACTACAGAATGTTTTCTCTTGGCAACAATGGCATAT GATCGCTATGTAGCCATATGCAAACCTTTACTATATCCAGTGATTATGAACAATTCACTA TGCATACGGCTGTTAGCCTTCTCATTTTTAGGTGGCTTCCTCCATGCCTTAATTCATGAA GTCCTTATATTCAGATTAACCTTCTGCAATTCTAACATAATACATCATTTTTACTGTGAT ATTATACCACTGTTTATGATTTCCTGTACTGACCCTTCTATTAATTTTCTAATGGTTTTT ATTTTGTCTGGCTCAATTCAGGTATTCACCATTGTGACAGTTCTTAATTCTTACACATTT GCTCTTTTCACAATCCTAAAAAAGAAGTCTGTTAGAGGCGTAAGGAAAGCCTTTTCCACC TGTGGAGCCCATCTCTTATCTGTCTCTTTATATTATGGCCCACTTATCTTCATGTATTTG CGCCCTGCATCTCCACAAGCAGATGACCAAGATATGATAGACTCTGTCTTTTATACAATC ATAATTCCTTTGCTAAATCCCATTATCTACAGTCTGAGAAATAAACAAGTAATAGATTCA TTCACAAAAATGGTAAAAAGAAATGTT |
| Conceptual translation |
MEQDNTTLLTEFVLTGLTYQPEWKMPLFLVFLVIYLITIVWNLGLIALIWNDPQLHIPMY FFLGSLAFVDAWISSTVTPKMLVNFLAKNRMISLSECMIQFFSFAFGGTTECFLLATMAY DRYVAICKPLLYPVIMNNSLCIRLLAFSFLGGFLHALIHEVLIFRLTFCNSNIIHHFYCD IIPLFMISCTDPSINFLMVFILSGSIQVFTIVTVLNSYTFALFTILKKKSVRGVRKAFST CGAHLLSVSLYYGPLIFMYLRPASPQADDQDMIDSVFYTIIIPLLNPIIYSLRNKQVIDS FTKMVKRNV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 3 | 98,002,587 | 98,002,587 | NS | A/G | I/V | rs16839611 (DbSNP) |
| 3 | 98,002,419 | 98,002,419 | NS | A/G | I/V | rs16839214 (DbSNP) |
| 3 | 98,001,777 | 98,001,777 | NS | C/G | Q/E | rs72487753 (DbSNP) |
| 3 | 98,002,576 | 98,002,576 | NS | C/T | S/F | rs72934925 (DbSNP) |
| 3 | 98,002,527 | 98,002,527 | NS | C/T | R/C | rs17787561 (DbSNP) |
| 3 | 98,002,445 | 98,002,445 | SYN | C/T | G/G | rs72934924 (DbSNP) |
| 3 | 98,282,933 | 98,282,933 | NS | G/C | E/Q | 1000GP (CEU, CHBJPT) |
| 3 | 98,283,575 | 98,283,575 | NS | A/G | I/V | 1000GP (CEU, CHBJPT) |
| 3 | 98,283,743 | 98,283,743 | NS | A/G | I/V | 1000GP (CEU, CHBJPT) |
| 3 | 100 | -100 | NS | G/C | E/Q | 1000GP (YRI, YRI, YRI, YRI) |
| 3 | 100 | -100 | SYN | C/T | G/G | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| E16Q | T43A | I230V | R266C | F282S | I286V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | E | T | I | R | F | I | 48.00 | 0.045 |
| 2 | E | T | I | R | F | V | 35.71 | 0.045 |
| 3 | Q | T | V | R | F | V | 13.90 | 0.045 |
| 4 | E | T | I | R | S | V | 0.69 | 0.045 |
| 5 | E | A | I | R | F | I | 0.69 | 0.045 |
| 6 | Q | T | I | R | F | V | 0.31 | 0.045 |
| 7 | Q | T | V | R | F | I | 0.31 | 0.045 |
| 8 | Q | T | I | R | F | I | 0.23 | 0.045 |
| 9 | E | T | V | R | F | V | 0.08 | 0.045 |
| 10 | Q | T | V | C | F | V | 0.08 | 0.045 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5H2.aApr07-unspliced | main_exon | 5UTR | chr3 | 98,282,888 | 98,282,903 | + |
| CDS | chr3 | 98,282,903 | 98,283,829 | + | ||
| 3UTR | chr3 | 98,283,829 | 98,283,832 | + | ||