OR5H6 Olfactory Receptor

Gene Symbol	OR5H6¹ (View this gene in GeneCards)
Family	5
Subfamily	H
Pseudogene	No
CORP pseudogene probability score
Aliases	OR3-11, HsOR3.3.11, ORL3094
External Ids	HGNC: 14767 GeneBank: AB065667, BK004374, NM_001005479 ORDB: ORL3094
Build #39 labels	OR5H6
Chromosomal location	3:98,264,333-98,265,259 (+)
Cluster	3@98
Synteny	CLIC#9
Remarks	Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs9289564 and rs9853887)

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR5H14	86.69%	308
OR5H7P	89.64%	309

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR5H13	76%	308
Mouse	Or5h26	75%	308
Rat	Or5h19-ps	74%	309
Cow	OR5H30	77%	306
Orang	OR5H8	80%	309
Orang	OR5H8BP	82%	256
Horse	OR5H8	76%	309
Chimp	OR5H7	89%	309
Chimp	OR5H14	88%	308
Chimp	OR5H14BP	86%	308

Expression evidences

Source	Accession
mRNA	BC137524
GNF Atlas2	gnf1h01994_at

Sequence information

Nucleotide sequence

ATGGAAGAGGAAAATGCAACATTGCTGACAGAGTTTGTTCTCACAGGATTTTTACATCAA
CCTGACTGTAAAATACCGCTCTTCCTGGCATTCTTGGTAATATATCTCATCACCATCATG
GGGAATCTTGGTCTAATTGTTCTCATCTGGAAAGACCCTCACCTTCATATCCCAATGTAC
TTATTCCTTGGGAGTTTAGCCTTTGTGGATGCTTCGTTATCATCCACAGTGACTCCGAAG
ATGCTGATCAACTTCTTAGCTAAGAGTAAGATGATATCTCTCTCTGAATGCATGGTACAA
TTTTTTTCCCTTGTAACCACTGTAACCACAGAATGTTTTCTCTTGGCAACAATGGCATAT
GATCGCTATGTAGCCATTTGCAAAGCTTTACTTTATCCAGTCATTATGACCAATGAACTA
TGCATTCAGCTATTAGTCTTGTCATTTATAGGTGGCCTTCTTCATGCTTTAATCCATGAA
GCTTTTTCATTCAGATTAACCTTCTGTAATTCCAACATAATACAACACTTTTACTGTGAC
ATTATCCCATTGTTAAAGATTTCCTGTACTGATTCCTCTATTAACTTTCTAATGGTTTTT
ATTTTCGCAGGTTCTGTTCAAGTTTTTACCATTGGAACTATTCTTATATCTTATACAATT
ATCCTCTTTACAATCTTAGAAAAGAAGTCTATCAAAGGGATACGAAAAGCTGTCTCCACC
TGTGGGGCTCATCTCTTATCTGTATCTTTATACTATGGCCCCCTCACCTTCAAATATCTG
GGCTCTGCATCTCCGCAAGCAGATGACCAAGATATGATGGAGTCTCTATTTTACACTGTC
ATAGTTCCTTTATTAAATCCCATGATCTACAGCCTGAGAAACAAGCAAGTAATAGCTTCA
TTCACAAAAATGTTCAAAAGCAATGTT

Conceptual translation

MEEENATLLTEFVLTGFLHQPDCKIPLFLAFLVIYLITIMGNLGLIVLIWKDPHLHIPMY
LFLGSLAFVDASLSSTVTPKMLINFLAKSKMISLSECMVQFFSLVTTVTTECFLLATMAY
DRYVAICKALLYPVIMTNELCIQLLVLSFIGGLLHALIHEAFSFRLTFCNSNIIQHFYCD
IIPLLKISCTDSSINFLMVFIFAGSVQVFTIGTILISYTIILFTILEKKSIKGIRKAVST
CGAHLLSVSLYYGPLTFKYLGSASPQADDQDMMESLFYTVIVPLLNPMIYSLRNKQVIAS
FTKMFKSNV

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
3	97,983,503	97,983,511	In-Del(9)	-/GGTTACAGT		rs11279406 (DbSNP)
3	97,983,396	97,983,395	Ins(9)	-/ACTGTAACC		rs11280482 (DbSNP)
3	97,983,265	97,983,265	NS	A/C	E/A	rs4241472 (DbSNP)
3	97,983,699	97,983,699	NS	A/C	K/Q	rs58475490 (DbSNP)
3	97,983,391	97,983,391	NS	A/C/G	multi/S	rs2173236 (DbSNP)
3	97,983,981	97,983,981	NS	A/G	N/D	rs9871143 (DbSNP)
3	97,983,942	97,983,942	NS	A/G	T/A	rs9853906 (DbSNP)
3	97,983,561	97,983,561	NS	C/G	P/A	rs9289564 (DbSNP)
3	97,983,253	97,983,253	NS	C/T	P/L	rs36040433 (DbSNP)
3	97,983,711	97,983,711	NS	C/T	R/C	rs9853887 (DbSNP)
3	97,983,664	97,983,664	NS	C/T	S/L	rs16846784 (DbSNP)
3	97,983,374	97,983,374	SYN	A/G	L/L	rs4857358 (DbSNP)
3	97,983,257	97,983,257	SYN	C/G	L/L	rs2132894 (DbSNP)
3	97,983,740	97,983,740	SYN	C/T	S/S	rs36116717 (DbSNP)
3	97,983,309	97,983,309	SYN	C/T	L/L	rs73854590 (DbSNP)
3	98,265,098	98,265,098	NS	A/G	T/A	1000GP (CEU, CHBJPT)
3	98,264,413	98,264,413	SYN	C/G	L/L	1000GP (CEU, CHBJPT)
3	98,264,547	98,264,547	NS	C/T	S/L	1000GP (CEU)
3	98,265,137	98,265,137	NS	G/A	D/N	1000GP (CEU)
3	98,264,758	98,264,758	SYN	T/C	I/I	1000GP (CHBJPT)
3	100	-100	NS	C/T	H/Y	1000GP (YRI, YRI, YRI)
3	100	-100	SYN	C/G	L/L	1000GP (YRI, YRI)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	E27Q	H35Y	A46E	I55V	L64V	L130I	A145P	I158N	Q191K	C195R	P199S	I237M	V254F	T272A	D285N	% Freq	CORP
1	E	H	A	I	L	L	P	I	Q	R	P	I	V	A	N	31.80	0.950
2	E	H	A	I	L	L	A	I	Q	C	P	I	V	T	D	25.50	0.950
3	E	H	E	I	L	L	P	I	Q	R	P	I	V	A	D	21.12	0.950
4	E	H	A	I	L	L	P	I	Q	R	P	I	V	A	D	9.37	0.950
5	E	Y	A	I	L	L	P	I	K	C	S	I	V	A	D	2.92	0.845
6	E	H	A	I	L	I	P	I	Q	C	P	I	V	A	D	2.53	0.652
7	E	H	A	I	L	L	P	I	K	C	P	I	V	T	D	2.00	0.950
8	E	Y	A	I	L	L	P	I	Q	R	P	I	V	A	D	0.92	0.845
9	E	H	A	I	L	L	P	I	K	R	P	I	V	T	D	0.84	0.950
10	E	H	A	I	L	L	P	I	K	C	P	M	V	A	D	0.38	0.950
11	E	H	A	I	L	L	P	I	Q	C	P	I	V	A	N	0.31	0.950
12	E	H	A	I	L	L	P	I	Q	C	P	I	V	A	D	0.31	0.950
13	E	H	A	I	L	L	A	I	Q	R	P	I	V	T	D	0.31	0.950
14	E	H	A	I	L	L	P	I	Q	R	P	I	F	A	N	0.15	0.967
15	E	H	A	I	L	L	P	I	Q	C	P	I	V	T	D	0.15	0.950
16	E	H	A	I	L	L	A	I	Q	C	S	I	V	T	D	0.08	0.950
17	E	H	A	V	L	L	P	I	Q	R	P	I	V	A	D	0.08	0.950
18	E	H	E	I	L	L	P	N	Q	R	P	I	V	A	D	0.08	0.950
19	E	H	E	I	L	I	P	I	Q	R	P	I	V	A	D	0.08	0.652
20	E	H	E	I	L	L	P	I	Q	C	P	I	V	A	D	0.08	0.950
21	E	H	E	V	L	L	P	I	Q	C	P	I	V	A	D	0.08	0.950
22	Q	H	A	I	L	L	P	I	Q	R	P	I	V	A	N	0.08	0.950
23	Q	H	E	I	L	L	P	I	Q	R	P	I	V	A	D	0.08	0.950
24	E	H	A	I	L	L	A	I	Q	C	P	I	V	A	D	0.08	0.950
25	E	H	A	I	L	L	A	N	Q	C	P	I	V	T	D	0.08	0.950
26	E	H	A	I	L	L	P	I	Q	C	P	M	V	A	D	0.08	0.950
27	E	H	E	I	L	L	A	I	Q	C	P	I	V	T	D	0.08	0.950
28	E	H	E	I	V	L	P	I	Q	R	P	I	V	A	D	0.08	0.950
29	E	H	E	I	L	I	A	I	Q	C	P	I	V	T	D	0.08	0.652
30	E	H	A	V	L	L	P	I	Q	R	P	I	V	A	N	0.08	0.950
31	E	H	A	I	L	I	P	I	Q	C	P	I	V	A	N	0.08	0.652
32	E	H	A	I	L	L	P	I	K	C	P	I	V	A	D	0.08	0.950
33	E	H	A	I	L	L	P	I	Q	R	P	I	V	T	D	0.08	0.950

AceView Gene Models

The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.

Accession	Type		Chr	Start	End	Strand
OR5H6.aApr07-unspliced	main_exon	5UTR	chr3	98,264,285	98,264,333	+
		CDS	chr3	98,264,333	98,265,259	+
		3UTR	chr3	98,265,259	98,265,262	+

HORDE

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