OR5L1 Olfactory Receptor

Gene Symbol	OR5L1¹ (View this gene in GeneCards)
Family	5
Subfamily	L
Pseudogene	No
CORP pseudogene probability score
Aliases	OR11-151, OST262, HsOR11.11.28, ORL3396
External Ids	HGNC: 8350 GeneBank: AB065780, BK004332, NM_001004738 ORDB: ORL3396
Build #39 labels	OR5L1
Chromosomal location	11:55,811,467-55,812,399 (+)
Cluster	11@56
Synteny	CLIC#26
Remarks	Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs12790505)

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR5L2	92.28%	311

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR5L1C	82%	311
Dog	OR5L1B	81%	308
Mouse	Or5l14	80%	311
Rat	Or5l14	78%	311
Cow	OR5L1C	77%	309
Orang	OR5G3	52%	308
Horse	OR5L1D	82%	311
Chimp	OR5L2	93%	311

Expression evidences

Source	Accession
mRNA	BC109250

Sequence information

Nucleotide sequence

ATGGGCAAGGAAAACTGCACCACTGTGGCTGAGTTCATTCTCCTTGGACTATCAGATGTC
CCTGAGTTGAGAGTCTGCCTCTTCCTGCTGTTCCTTCTCATCTATGGAGTCACGTTGTTA
GCCAACCTGGGCATGATTGCACTGATTCAGGTCAGCTCTCGGCTCCACACCCCCATGTAC
TTTTTCCTCAGCCACTTGTCCTCTGTAGATTTCTGCTACTCCTCAATAATTGTGCCAAAA
ATGTTGGCTAATATCTTTAACAAGGACAAAGCCATCTCCTTCCTAGGGTGCATGGTGCAA
TTCTACTTGTTTTGCACTTGTGTGGTCACTGAGGTCTTCCTGCTGGCCGTGATGGCCTAT
GACCGCTTTGTGGCCATCTGTAACCCTTTGCTATACACAGTCACCATGTCTTGGAAGGTG
CGTGTGGAGCTGGCTTCTTGCTGCTACTTCTGTGGGACGGTGTGTTCTCTGATTCATTTG
TGCTTAGCTCTTAGGATCCCCTTCTATAGATCTAATGTGATTAACCACTTTTTCTGTGAT
CTACCTCCTGTCTTAAGTCTTGCTTGCTCTGATATCACTGTGAATGAGACACTGCTGTTC
CTGGTGGCCACTTTGAATGAGAGTGTTACCATCATGATCATCCTCACCTCCTACCTGCTA
ATTCTCACCACCATCCTGAAGATGGGCTCTGCAGAGGGCAGGCACAAAGCCTTCTCCACC
TGTGCTTCCCACCTCACAGCTATCACTGTCTTCCATGGAACAGTCCTTTCCATTTATTGC
AGGCCCAGTTCAGGCAATAGTGGAGATGCTGACAAAGTGGCCACCGTGTTCTACACAGTC
GTGATTCCTATGCTGAACTCTGTGATCTACAGCCTGAGAAATAAAGATGTGAAAGAAGCT
CTCAGAAAAGTGATGGGCTCCAAAATTCACTCC

Conceptual translation

MGKENCTTVAEFILLGLSDVPELRVCLFLLFLLIYGVTLLANLGMIALIQVSSRLHTPMY
FFLSHLSSVDFCYSSIIVPKMLANIFNKDKAISFLGCMVQFYLFCTCVVTEVFLLAVMAY
DRFVAICNPLLYTVTMSWKVRVELASCCYFCGTVCSLIHLCLALRIPFYRSNVINHFFCD
LPPVLSLACSDITVNETLLFLVATLNESVTIMIILTSYLLILTTILKMGSAEGRHKAFST
CASHLTAITVFHGTVLSIYCRPSSGNSGDADKVATVFYTVVIPMLNSVIYSLRNKDVKEA
LRKVMGSKIHS

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
11	55,579,783	55,579,783	NS	A/G	M/V	rs61735738 (DbSNP)
11	55,579,291	55,579,291	NS	A/G	M/V	rs59122940 (DbSNP)
11	55,579,078	55,579,078	NS	A/T	I/F	rs2869020 (DbSNP)
11	55,579,868	55,579,868	NS	C/T	T/I	rs61732350 (DbSNP)
11	55,579,102	55,579,102	NS	C/T	R/W	rs34961497 (DbSNP)
11	55,579,801	55,579,801	NS	C/T	P/S	rs12790505 (DbSNP)
11	55,579,092	55,579,092	NS	G/T	Q/H	rs61998198 (DbSNP)
11	55,579,419	55,579,419	SYN	C/T	H/H	rs34948392 (DbSNP)
11	55,578,987	55,578,987	SYN	C/T	L/L	rs67727364 (DbSNP)
11	55,578,991	55,578,991	SYN	C/T	L/L	rs66537410 (DbSNP)
11	55,811,943	55,811,943	SYN	T/C	H/H	1000GP (CEU, CHBJPT)
11	55,812,325	55,812,325	NS	T/C	S/P	1000GP (CEU, CHBJPT)
11	55,811,626	55,811,626	NS	C/T	R/W	1000GP (CEU, CHBJPT)
11	100	-100	NS	A/T	I/F	1000GP (YRI, YRI, YRI, YRI)
11	100	-100	SYN	T/C	H/H	1000GP (YRI)

Variations - CNVs

Chr	Start	End	Type	Sources
11	55,153,930	55,816,828	CopyNumber	Variation_0308 (DGV)
11	55,446,295	55,618,623	CopyNumber	Variation_2167 (DGV)
11	55,339,702	55,638,112	CopyNumber	Variation_2926 (DGV)
11	55,222,420	55,621,884	CopyNumber	Variation_3852 (DGV)
11	54,835,623	55,879,426	CopyNumber	Variation_8690 (DGV)
11	55,445,294	55,620,699	CopyNumber	Variation_9187 (DGV)
11	55,377,006	55,620,699	CopyNumber	Variation_9188 (DGV)
11	55,422,586	55,596,313	CopyNumber	Variation_10360 (DGV)
11	55,422,585	55,596,313	CopyNumber	Variation_29911 (DGV)
11	55,463,782	55,584,109	CopyNumber	Variation_48056 (DGV)
11	55,437,126	55,596,313	CopyNumber	Variation_48840 (DGV)
11	55,442,368	55,596,313	CopyNumber	Variation_48841 (DGV)
11	55,444,868	55,591,047	CopyNumber	Variation_48842 (DGV)
11	55,444,868	55,596,313	CopyNumber	Variation_48843 (DGV)
11	55,447,427	55,596,313	CopyNumber	Variation_53429 (DGV)
11	55,422,345	55,603,590	CopyNumber	Variation_65956 (DGV)
11	55,560,070	55,602,798	CopyNumber	Variation_85785 (DGV)
11	55,578,843	55,581,875	Deletion	#290 (Waszak)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	I46F	R54W	T153M	V281M	S287P	% Freq	CORP
1	I	R	T	V	S	85.71	0.595
2	I	W	T	V	P	9.37	0.040
3	F	R	T	V	S	2.53	0.595
4	I	R	T	V	P	1.23	0.040
5	I	R	T	M	S	0.54	0.595
6	I	W	T	V	S	0.46	0.595
7	I	R	M	V	S	0.08	0.595
8	I	W	M	V	P	0.08	0.040

AceView Gene Models

The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.

Accession	Type		Chr	Start	End	Strand
OR5L1.aApr07-unspliced	main_exon	CDS	chr11	55,811,467	55,812,399	+
OR5L1.aApr07-unspliced	main_exon	3UTR	chr11	55,812,399	55,812,402	+

HORDE

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