OR6A2 Olfactory Receptor
| Gene Symbol | OR6A21 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.21 (functional) |
| Aliases | OR11-55, OR11-72, OR11-80, OR11-84, OR11-77, HsOR11.4.3 |
| External Ids | HGNC: 15301 GeneBank: AB065822, AF399472, BK004533, BK004672, BK004735, NM_003696 |
| Build #39 labels | OR6A2, OR6A1 |
| Chromosomal location | 11:6,794,728-6,795,708 (-) |
| Cluster | 11@7 |
| Synteny | CLIC#24 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6B1 | 57.84% | 306 |
| OR6P1 | 58.72% | 298 |
| OR6Y1 | 57.56% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6B9 | 60% | 303 |
| Mouse | Or6a2 | 90% | 326 |
| Rat | Or6a2 | 90% | 326 |
| Rat | Or6a2b | 90% | 326 |
| Cow | OR6B9 | 61% | 304 |
| Orang | OR6B3P | 60% | 298 |
| Horse | OR6A3P | 78% | 316 |
| Chimp | OR6P1 | 58% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC101491 |
| GNF Atlas2 | 221465_at |
Sequence information
| Nucleotide sequence |
ATGGAGTGGCGGAACCATAGTGGGAGAGTGAGTGAGTTTGTGTTGCTGGGCTTCCCTGCT CCTGCGCCACTACAGGTACTATTGTTTGCCCTTTTGCTGCTGGCCTATGTGTTGGTGCTG ACTGAGAACACACTCATCATTATGGCAATTAGGAACCATTCTACCCTCCACAAACCCATG TACTTTTTTCTAGCTAATATGTCCTTTCTGGAGATCTGGTATGTCACTGTCACTATTCCC AAGATGCTTGCTGGCTTTGTTGGATCCAAACAGGATCATGGACAGCTAATCTCCTTTGAG GGATGCATGACACAGCTCTACTTTTTCCTTGGCTTGGGCTGCACTGAGTGTGTCCTTCTC GCTGTTATGGCCTATGATCGCTATATGGCCATCTGCTATCCTCTCCACTACCCAGTCATT GTCAGTGGCCGGCTGTGTGTGCAGATGGCTGCTGGCTCTTGGGCTGGAGGTTTTGGCATC TCCATGGTCAAAGTTTTTCTTATTTCTGGCCTCTCTTACTGTGGCCCCAACATCATCAAC CACTTTTTCTGTGATGTCTCTCCATTGCTCAACCTCTCATGCACTGATATGTCCACAGCA GAGCTTACAGATTTCATCCTGGCCATTTTTATTCTTCTAGGGCCACTCTCTGTCACTGGG GCCTCCTATGTGGCCATTACTGGTGCTGTGATGCACATTCCTTCGGCTGCTGGACGCTAT AAGGCCTTTTCCACCTGTGCCTCTCATCTCACTGTTGTGATAATCTTCTATGCAGCCAGT ATCTTCATCTATGCTCGGCCAAAGGCACTCTCAGCTTTTGACACCAACAAGTTGGTCTCT GTACTGTATGCTGTCATTGTACCATTGCTCAATCCCATCATTTACTGCCTGCGCAATCAA GAGGTCAAGAGAGCCCTATGCTGTACTCTGCACCTGTACCAGCACCAGGATCCTGACCCC AAGAAAGCTAGCAGAAATGTA |
| Conceptual translation |
MEWRNHSGRVSEFVLLGFPAPAPLQVLLFALLLLAYVLVLTENTLIIMAIRNHSTLHKPM YFFLANMSFLEIWYVTVTIPKMLAGFVGSKQDHGQLISFEGCMTQLYFFLGLGCTECVLL AVMAYDRYMAICYPLHYPVIVSGRLCVQMAAGSWAGGFGISMVKVFLISGLSYCGPNIIN HFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSVTGASYVAITGAVMHIPSAAGRY KAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLLNPIIYCLRNQ EVKRALCCTLHLYQHQDPDPKKASRNV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 6,816,293 | 6,816,294 | Del(2) | -/AG | rs71946386 (DbSNP) | |
| 11 | 6,816,875 | 6,816,875 | NS | A/G | V/A | rs7122644 (DbSNP) |
| 11 | 6,816,792 | 6,816,792 | NS | C/T | V/I | rs61741824 (DbSNP) |
| 11 | 6,816,317 | 6,816,317 | NS | G/A | A/V | rs61741823 (DbSNP) |
| 11 | 6,816,242 | 6,816,242 | NS | G/A | T/I | rs2741744 (DbSNP) |
| 11 | 6,816,240 | 6,816,240 | NS | G/A | P/S | rs2741745 (DbSNP) |
| 11 | 6,816,579 | 6,816,579 | NS | T/C | T/A | rs61741822 (DbSNP) |
| 11 | 6,816,778 | 6,816,778 | SYN | A/G | S/S | rs866347 (DbSNP) |
| 11 | 6,795,547 | 6,795,547 | SYN | A/G | S/S | 1000GP (CEU, CHBJPT) |
| 11 | 6,795,644 | 6,795,644 | NS | G/A | A/V | 1000GP (CEU, CHBJPT) |
| 11 | 6,795,561 | 6,795,561 | NS | T/C | I/V | 1000GP (CEU) |
| 11 | 100 | -100 | NS | C/T | A/T | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | A/G | S/S | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 6,813,959 | 6,817,039 | CopyNumber | #137 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A259T | V253A | A208V | H93Y | I50V | A22V | R4Q | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A | V | A | H | I | A | R | 66.59 | 0.620 |
| 2 | A | V | A | H | I | V | R | 29.19 | 0.620 |
| 3 | A | V | A | H | V | A | R | 1.69 | 0.620 |
| 4 | T | V | A | H | I | A | R | 0.84 | 0.620 |
| 5 | A | V | V | H | I | A | R | 0.61 | 0.620 |
| 6 | A | V | A | Y | I | A | R | 0.46 | 0.620 |
| 7 | A | V | A | H | I | A | Q | 0.31 | 0.620 |
| 8 | A | A | A | H | I | A | R | 0.23 | 0.750 |
| 9 | T | V | A | H | I | V | R | 0.08 | 0.620 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6A2.aApr07-unspliced | main_exon | 3UTR | chr11 | 6,794,525 | 6,794,728 | - |
| CDS | chr11 | 6,794,728 | 6,795,708 | - | ||
| 5UTR | chr11 | 6,795,708 | 6,795,908 | - | ||