OR6C2 Olfactory Receptor
| Gene Symbol | OR6C21 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.05 (functional) |
| Aliases | HSA3, HsOR12.5.19, ORL3812 |
| External Ids | HGNC: 15436 GeneBank: AF179766, NM_054105, XM_498546 ORDB: ORL3812 |
| Build #39 labels | OR6C2 |
| Chromosomal location | 12:55,452,214-55,453,149 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C68 | 74.68% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C2E | 87% | 312 |
| Dog | OR6C2D | 87% | 312 |
| Dog | OR6C2IP | 85% | 313 |
| Mouse | Or6c2 | 90% | 312 |
| Rat | Or6c2 | 89% | 312 |
| Rat | Or6c2c | 88% | 291 |
| Cow | OR6C2F | 78% | 312 |
| Orang | OR6C308 | 79% | 312 |
| Horse | OR6C2K | 86% | 312 |
| Chimp | OR6C68 | 75% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BG205103 |
| mRNA | AB528770 |
Sequence information
| Nucleotide sequence |
ATGAAAAACCACACAGTAATAAGAACTTTTATCCTGCTGGGACTGACAGGTGACCCACAC CTGCAAGTTCTGCTTTTTATCTTTCTATTTCTCACCTACATGTTGAGTGTAACAGGGAAC CTGACTATTATCACCCTCACATTGGTGGACCACCACCTTAAAACTCCTATGTACTTCTTT CTCAGAAATTTTTCCTTCTTAGAAGTCTCATTTACTACAGTCTGCATTCCCAGATTCTTG TACAATATATCAATGGGGGACAATACCATTACCTACAATGCTTGTGCCAGTCAAATATTC TTTGTTATTCTCTTTGGAGCAACAGAATTTTTTCTCTTGGCAGCCATGTCCTATGACCGC TATGTGGCCATCTGTAAACCCCTTCATTATGTGGTCATCATGAACAACAGGGTGTGTACC TTATTAGTTCTCTGCTGTTGGGTGGCTGGCTTGATGATCATTGTTCCACCACTTAGCTTA GGCCTCCAGCTCGAATTCTGTGACTCCAATGCCATTGATCATTTTAGCTGTGATGCAGGT CCTCTCCTAAAGATCTCATGCTCAGATACATGGGTAATAGAACAGATGGTTATACTTATG GCTGTATTTGCACTCATTATCACCCTAGTTTGTGTGATTCTGTCCTACTTGTACATAGTC AGAACAATTCTGAAGTTCCCTTCTGTTCAGCAAAGGAAAAAGGCCTTTTCTACCTGTTCA TCCCACATGATTGTGGTTTCCATTGCCTATGGAAGCTGCATCTTCATCTATATCAAGCCC TCTGCAAAAGATGAGGTGGCCATAAATAAAGGAGTTTCAGTTCTTACTACTTCTGTCGCA CCCTTGTTGAACCCCTTCATTTACACCTTGAGGAACAAGCAAGTGAAACAAGCTTTCAGT GACTCTATAAAGAGGATTGCATTTCTCTCAAAGAAG |
| Conceptual translation |
MKNHTVIRTFILLGLTGDPHLQVLLFIFLFLTYMLSVTGNLTIITLTLVDHHLKTPMYFF LRNFSFLEVSFTTVCIPRFLYNISMGDNTITYNACASQIFFVILFGATEFFLLAAMSYDR YVAICKPLHYVVIMNNRVCTLLVLCCWVAGLMIIVPPLSLGLQLEFCDSNAIDHFSCDAG PLLKISCSDTWVIEQMVILMAVFALIITLVCVILSYLYIVRTILKFPSVQQRKKAFSTCS SHMIVVSIAYGSCIFIYIKPSAKDEVAINKGVSVLTTSVAPLLNPFIYTLRNKQVKQAFS DSIKRIAFLSKK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 55,846,204 | 55,846,203 | Ins(1) | -/G | rs34885470 (DbSNP) | |
| 12 | 55,846,773 | 55,846,773 | NS | A/G | K/R | rs73339457 (DbSNP) |
| 12 | 55,846,538 | 55,846,538 | NS | C/G | P/A | rs11171466 (DbSNP) |
| 12 | 55,846,623 | 55,846,623 | NS | C/T | P/L | rs11171467 (DbSNP) |
| 12 | 55,846,890 | 55,846,890 | NS | C/T | A/V | rs74092333 (DbSNP) |
| 12 | 55,846,649 | 55,846,649 | NS | G/T | D/Y | rs12817326 (DbSNP) |
| 12 | 55,846,731 | 55,846,731 | NS | G/T | G/V | rs12810501 (DbSNP) |
| 12 | 55,453,010 | 55,453,010 | NS | T/A | V/E | 1000GP (CEU) |
| 12 | 55,452,839 | 55,452,839 | NS | T/C | L/P | 1000GP (CEU) |
| 12 | 55,452,754 | 55,452,754 | NS | C/G | P/A | 1000GP (CHBJPT) |
| 12 | 100 | -100 | SYN | C/T | L/L | 1000GP (YRI, YRI) |
| 12 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,832,210 | 56,001,052 | CopyNumber | Variation_4780 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I154V | P181A | L209P | Q231H | I244T | K259R | V266E | A298V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | P | L | Q | I | K | V | A | 80.49 | 0.131 |
| 2 | I | P | P | Q | I | K | V | A | 10.75 | 0.131 |
| 3 | I | A | L | Q | I | K | V | A | 2.69 | 0.131 |
| 4 | I | P | L | Q | I | R | V | A | 2.38 | 0.131 |
| 5 | I | P | L | Q | I | K | V | V | 2.15 | 0.131 |
| 6 | I | P | L | Q | T | K | V | A | 1.00 | 0.131 |
| 7 | I | P | L | H | I | K | V | A | 0.15 | 0.131 |
| 8 | I | P | P | Q | I | K | E | A | 0.15 | 0.131 |
| 9 | I | P | L | Q | I | R | V | V | 0.15 | 0.131 |
| 10 | V | P | P | Q | I | K | V | A | 0.08 | 0.131 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C2.aApr07-unspliced | main_exon | CDS | chr12 | 55,452,214 | 55,453,149 | + |
| 3UTR | chr12 | 55,453,149 | 55,453,152 | + | ||