OR6C4 Olfactory Receptor
| Gene Symbol | OR6C41 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.08 (functional) |
| Aliases | OR12-10, HsOR12.5.23 |
| External Ids | HGNC: 19632 GeneBank: AB065869, BK004261, NM_001005494 |
| Build #39 labels | OR6C4 |
| Chromosomal location | 12:55,551,227-55,552,153 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2AP1 | 80.26% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C4B | 87% | 309 |
| Mouse | Or6c63-ps | 77% | 309 |
| Rat | Or6c63 | 76% | 309 |
| Cow | OR6C4C | 91% | 308 |
| Orang | OR6C8P | 76% | 309 |
| Horse | OR6C4D | 90% | 309 |
| Horse | OR6C4FP | 90% | 309 |
| Chimp | OR6C8 | 82% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC137001 |
Sequence information
| Nucleotide sequence |
ATGAAAAACAGAACCATGTTTGGTGAGTTTATTCTACTGGGCCTTACAAATCAACCTGAA CTCCAAGTGATGATATTCATCTTTCTGTTCCTCACCTACATGCTAAGTATCCTAGGAAAT CTGACTATTATCACCCTCACCTTACTAGACCCCCACCTCCAGACCCCCATGTATTTCTTC CTCCGGAATTTCTCCTTCTTAGAAATTTCCTTCACATCCATTTTTATTCCCAGATTTCTG ACCAGCATGACAACAGGAAATAAAGTTATCAGCTTTGCTGGCTGCTTGACTCAGTATTTT TTTGCTATATTTCTTGGAGCTACCGAGTTTTACCTCCTGGCCTCCATGTCTTATGATCGT TATGTGGCCATCTGCAAACCCTTGCATTACCTGACTATTATGAGCAGCAGAGTCTGCATA CAACTAGTGTTCTGCTCCTGGTTGGGGGGATTCCTAGCAATCTTACCACCAATCATCCTG ATGACCCAGGTAGATTTCTGTGTCTCCAACATTCTGAATCACTATTACTGTGACTATGGG CCTCTCGTGGAGCTTGCCTGCTCAGACACAAGCCTCTTAGAACTGATGGTCATCCTCTTG GCCGTTGTGACTCTCATGGTTACTCTGGTGCTGGTGACACTTTCTTACACATACATTATC AGGACTATTCTGAGGATCCCTTCTGCCCAGCAAAGGACAAAGGCCTTTTCCACTTGTTCC TCCCACATGATTGTCATCTCCCTCTCTTATGGCAGCTGCATGTTTATGTACATTAATCCT TCTGCAAAAGAAGGAGGTGCTTTCAACAAAGGAATAGCTGTACTCATTACTTCGGTTACT CCCTTACTGAATCCCTTCATATATACTTTAAGAAATCAGCAAGTGAAACAAGCTTTCAAG GACTCAGTCAAAAAGATTGTGAAACTT |
| Conceptual translation |
MKNRTMFGEFILLGLTNQPELQVMIFIFLFLTYMLSILGNLTIITLTLLDPHLQTPMYFF LRNFSFLEISFTSIFIPRFLTSMTTGNKVISFAGCLTQYFFAIFLGATEFYLLASMSYDR YVAICKPLHYLTIMSSRVCIQLVFCSWLGGFLAILPPIILMTQVDFCVSNILNHYYCDYG PLVELACSDTSLLELMVILLAVVTLMVTLVLVTLSYTYIIRTILRIPSAQQRTKAFSTCS SHMIVISLSYGSCMFMYINPSAKEGGAFNKGIAVLITSVTPLLNPFIYTLRNQQVKQAFK DSVKKIVKL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 55,945,585 | 55,945,588 | Del(4) | -/TCTT | rs59693527 (DbSNP) | |
| 12 | 55,945,119 | 55,945,119 | NS | A/G | I/V | rs7313899 (DbSNP) |
| 12 | 55,945,258 | 55,945,258 | NS | C/T | T/M | rs11835716 (DbSNP) |
| 12 | 55,945,219 | 55,945,219 | NS | C/T | S/F | rs58154171 (DbSNP) |
| 12 | 55,945,265 | 55,945,265 | SYN | A/G | T/T | rs74093226 (DbSNP) |
| 12 | 55,945,856 | 55,945,856 | SYN | A/G | L/L | rs57386660 (DbSNP) |
| 12 | 55,551,335 | 55,551,335 | NS | A/G | I/V | 1000GP (CEU, CHBJPT) |
| 12 | 55,551,474 | 55,551,474 | NS | T/C | M/T | 1000GP (CHBJPT) |
| 12 | 55,551,762 | 55,551,762 | NS | A/G | Y/C | 1000GP (CHBJPT) |
| 12 | 55,552,072 | 55,552,072 | SYN | A/G | L/L | 1000GP (CHBJPT) |
| 12 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | A/G | T/T | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,832,210 | 56,001,052 | CopyNumber | Variation_4780 (DGV) |
| CopyNumber | 19 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I37V | S70F | M83T | E109K | Y179C | L205F | V210M | Q230K | N269I | Q297* | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | V | S | M | E | Y | L | V | Q | N | Q | 85.64 | 0.244 |
| 2 | V | S | T | E | Y | L | V | Q | N | Q | 9.75 | 0.244 |
| 3 | V | F | T | E | Y | L | V | Q | N | Q | 1.77 | 0.244 |
| 4 | I | S | M | E | Y | L | V | Q | N | Q | 0.84 | 0.244 |
| 5 | V | S | T | K | Y | L | V | Q | N | Q | 0.77 | 0.285 |
| 6 | V | F | T | E | Y | L | V | K | N | Q | 0.38 | 0.244 |
| 7 | V | S | M | E | Y | F | V | Q | N | Q | 0.31 | 0.244 |
| 8 | V | F | T | E | Y | L | V | Q | I | Q | 0.15 | 0.244 |
| 9 | V | S | M | E | Y | L | V | Q | N | * | 0.08 | 1.200 |
| 10 | V | S | T | E | C | L | V | Q | N | Q | 0.08 | 0.244 |
| 11 | V | S | M | E | C | L | V | Q | N | Q | 0.08 | 0.244 |
| 12 | V | S | M | E | Y | L | M | Q | N | Q | 0.08 | 0.244 |
| 13 | I | S | T | E | Y | L | V | Q | N | Q | 0.08 | 0.244 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C4.aApr07-unspliced | main_exon | CDS | chr12 | 55,551,227 | 55,552,153 | + |
| 3UTR | chr12 | 55,552,153 | 55,552,156 | + | ||