OR6C74 Olfactory Receptor
| Gene Symbol | OR6C741 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | HsOR12.5.6 |
| External Ids | HGNC: 31303 GeneBank: NM_001005490 |
| Build #39 labels | |
| Chromosomal location | 12:55,247,288-55,248,223 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C66P | 73.77% | 305 |
| OR6C75 | 72.99% | 311 |
| OR6C76 | 73.53% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C75C | 73% | 312 |
| Mouse | Or6c74 | 89% | 310 |
| Rat | Or6c74 | 88% | 312 |
| Rat | Or6c74b | 88% | 312 |
| Cow | OR6C74C | 88% | 312 |
| Orang | OR6C66 | 75% | 306 |
| Horse | OR6C74EP | 84% | 311 |
| Chimp | OR6C4 | 68% | 306 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140754 |
Sequence information
| Nucleotide sequence |
ATGAGAAACCATACAACAGTAGCAAACTTTATTCTTCTTGGACTGACAGATGATCCACAA TTACAGGTGATTATTTTTCTTCTCCTTTTTTTCACCTACATGTTGAGCATCACTGGGAAT CTAACCATCATCACTCTCACCCTACTGGATTTGCATCTCAAGACACCCATGTATTTCTTC CTCCGAAATTTCTCATTTTTAGAAGTCTCATTCACAACTGTCTACATTCCCAAATTTCTT GTTAGTATGGCAACAGGTGATAAGACCATTTCTTACAACGATTGTGCAGCACAGCTGTTT TTCACTATTCTCTTGGGGGCAACTGAATTTTTTCTTCTGGCTGCCATGTCCTATGAGCGC TATGTGGCCATCTGCAAACCCCTGCATTACACCACCATCATGAGCAGCAGAGTTTGCAGC TTGCTGGTCTTTGCTTCATGGATGGCTGGCTTCCTAATAATTTTTCCGCCACTCCTGATG GGTCTCCAGCTTGATTTCTGTGCAGCCAACACTGTAGATCATTTCTTCTGTGATGTTTCT CCTATACTGCAGCTCTCTTGCACAGACACTGACATAATAGAATTAATGATGCTTCTCTCA GCCATTTTGACGCTCCTGGTTACACTGGTATTAGTGATTCTCTCCTACACAAATATTATC AGGACTATTCTGAAAATACCTTCTTCTCAACAGAGAAAAAAAGCATTTTCTACATGTTCT TCCCACATGGTGGTCGTGTCCATTTCTTATGGCAGCTGCATCTTCATGTATGTGAAACCC TCAGCAAAAGAAAGAGTGTCATTAAATAAAGGGATAGCTCTGCTCAGCACTTCTGTTGCC CCCATGTTGAATCCCTTTATTTATACACTGAGAAACAAACAAGTAAAAGATGTTTTTAAG CACACAGTCAAAAAGATTGAACTTTTCTCAATGAAA |
| Conceptual translation |
MRNHTTVANFILLGLTDDPQLQVIIFLLLFFTYMLSITGNLTIITLTLLDLHLKTPMYFF LRNFSFLEVSFTTVYIPKFLVSMATGDKTISYNDCAAQLFFTILLGATEFFLLAAMSYER YVAICKPLHYTTIMSSRVCSLLVFASWMAGFLIIFPPLLMGLQLDFCAANTVDHFFCDVS PILQLSCTDTDIIELMMLLSAILTLLVTLVLVILSYTNIIRTILKIPSSQQRKKAFSTCS SHMVVVSISYGSCIFMYVKPSAKERVSLNKGIALLSTSVAPMLNPFIYTLRNKQVKDVFK HTVKKIELFSMK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | nonsense SNP | C/T | R/* | 1000GP (YRI) |
| 12 | 100 | -100 | NS | A/G | R/G | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | G/A | L/L | 1000GP (YRI, YRI, YRI) |
| 12 | 55,247,291 | 55,247,291 | NS | A/G | R/G | 1000GP (CEU, CHBJPT) |
| 12 | 55,247,471 | 55,247,471 | nonsense SNP | C/T | R/* | 1000GP (CEU, CHBJPT) |
| 12 | 55,247,511 | 55,247,511 | NS | A/G | Y/C | 1000GP (CEU, CHBJPT) |
| 12 | 55,247,544 | 55,247,544 | NS | G/A | G/D | 1000GP (CEU, CHBJPT) |
| 12 | 55,247,547 | 55,247,547 | NS | A/T | D/V | 1000GP (CHBJPT) |
| 12 | 55,247,645 | 55,247,645 | NS | C/T | R/C | 1000GP (CHBJPT) |
| 12 | 55,247,966 | 55,247,966 | NS | C/T | P/S | 1000GP (CEU) |
| 12 | 55,248,027 | 55,248,027 | NS | C/T | S/F | 1000GP (CEU) |
| 12 | 55,248,136 | 55,248,136 | SYN | G/A | L/L | 1000GP (CHBJPT) |
| 12 | 55,641,075 | 55,641,075 | NS | A/G | R/G | rs7301705 (DbSNP) |
| 12 | 55,641,218 | 55,641,218 | SYN | A/G | L/L | rs11171387 (DbSNP) |
| 12 | 55,641,252 | 55,641,252 | NS | C/T | L/F | rs11171388 (DbSNP) |
| 12 | 55,641,255 | 55,641,255 | nonsense SNP | C/T | R/* | rs4522268 (DbSNP) |
| 12 | 55,641,263 | 55,641,263 | SYN | C/T | F/F | rs11171389 (DbSNP) |
| 12 | 55,641,295 | 55,641,295 | NS | A/G | Y/C | rs4388990 (DbSNP) |
| 12 | 55,641,328 | 55,641,328 | NS | A/G | D/G | rs6581025 (DbSNP) |
| 12 | 55,641,429 | 55,641,429 | NS | C/T | R/C | rs4321039 (DbSNP) |
| 12 | 55,641,920 | 55,641,920 | SYN | A/G | L/L | rs73322883 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 106 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R2G | L61F | R62* | Y75C | G86D | D87V | R120C | S247F | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R | L | R | Y | G | D | R | S | 69.59 | 1.000 |
| 2 | G | L | * | C | D | D | R | S | 18.97 | 1.200 |
| 3 | R | F | R | Y | G | D | R | S | 6.14 | 1.000 |
| 4 | R | L | * | C | G | D | C | S | 1.84 | 1.200 |
| 5 | G | L | * | C | D | D | R | F | 1.15 | 1.200 |
| 6 | R | L | R | Y | D | D | R | S | 1.00 | 1.000 |
| 7 | R | L | R | Y | G | V | R | S | 0.61 | 1.000 |
| 8 | G | L | * | Y | D | D | R | F | 0.23 | 1.200 |
| 9 | G | L | * | C | G | D | R | S | 0.15 | 1.200 |
| 10 | G | L | R | Y | G | D | R | S | 0.08 | 1.000 |
| 11 | R | L | * | Y | G | D | R | S | 0.08 | 1.200 |
| 12 | G | L | * | Y | G | D | R | F | 0.08 | 1.200 |
| 13 | G | L | R | C | D | D | R | S | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C74.aApr07-unspliced | main_exon | CDS | chr12 | 55,247,288 | 55,248,223 | + |
| 3UTR | chr12 | 55,248,223 | 55,248,226 | + | ||