OR6F1 Olfactory Receptor
| Gene Symbol | OR6F11 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | F |
| Pseudogene | No |
| CORP pseudogene probability score | 0.11 (functional) |
| Aliases | OR1-38, OR1-34, HsOR1.5.7, ORL3020 |
| External Ids | HGNC: 15027 GeneBank: AB065619, AF399604, AY284133-AY284164, BK004460, BK004745, NM_001005286 ORDB: ORL3020 |
| Build #39 labels | OR6F1 |
| Chromosomal location | 1:247,711,832-247,712,755 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6A2 | 50.85% | 295 |
| OR6M1 | 52.68% | 298 |
| OR6N1 | 51.96% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6M2 | 52% | 301 |
| Mouse | Or6f1 | 83% | 308 |
| Rat | Or6f1 | 84% | 306 |
| Rat | Or6f1b | 84% | 306 |
| Cow | OR6F3P | 58% | 312 |
| Orang | OR6N1 | 53% | 306 |
| Horse | OR6AE1 | 54% | 303 |
| Chimp | OR6N1 | 53% | 306 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | DB336294 |
| mRNA | BC137143 |
| GNF Atlas2 | gnf1h07039_at |
Sequence information
| Nucleotide sequence |
ATGGACACAGGCAACAAAACTCTGCCCCAGGACTTTCTCTTACTGGGCTTTCCTGGTTCT CAAACTCTTCAGCTCTCTCTCTTTATGCTTTTTCTGGTGATGTACATCCTCACAGTTAGT GGTAATGTGGCTATCTTGATGTTGGTGAGCACCTCCCATCAGTTGCATACCCCCATGTAC TTCTTTCTGAGCAACCTCTCCTTCCTGGAGATTTGGTATACCACAGCAGCAGTGCCCAAA GCACTGGCCATCCTACTGGGGAGAAGTCAGACCATATCATTTACAAGCTGTCTTTTGCAG ATGTACTTTGTTTTCTCATTAGGCTGCACAGAGTACTTCCTCCTGGCAGCCATGGCTTAT GACCGCTGTCTTGCCATCTGCTATCCTTTACACTACGGAGCCATCATGAGTAGCCTGCTC TCAGCGCAGCTGGCCCTGGGCTCCTGGGTGTGTGGTTTCGTGGCCATTGCAGTGCCCACA GCCCTCATCAGTGGCCTGTCCTTCTGTGGCCCCCGTGCCATCAACCACTTCTTCTGTGAC ATTGCACCCTGGATTGCCCTGGCCTGCACCAACACACAGGCAGTAGAGCTTGTGGCCTTT GTGATTGCTGTTGTGGTTATCCTGAGTTCATGCCTCATCACCTTTGTCTCCTATGTGTAC ATCATCAGCACCATCCTCAGGATCCCCTCTGCCAGTGGCCGGAGCAAAGCCTTCTCCACG TGCTCCTCGCATCTCACCGTGGTGCTCATTTGGTATGGGTCCACAGTTTTCCTTCACGTC CGCACCTCTATCAAAGATGCCTTGGATCTGATCAAAGCTGTCCACGTCCTGAACACTGTG GTGACTCCAGTTTTAAACCCCTTCATCTATACGCTTCGTAATAAGGAAGTAAGAGAGACT CTGCTGAAGAAATGGAAGGGAAAA |
| Conceptual translation |
MDTGNKTLPQDFLLLGFPGSQTLQLSLFMLFLVMYILTVSGNVAILMLVSTSHQLHTPMY FFLSNLSFLEIWYTTAAVPKALAILLGRSQTISFTSCLLQMYFVFSLGCTEYFLLAAMAY DRCLAICYPLHYGAIMSSLLSAQLALGSWVCGFVAIAVPTALISGLSFCGPRAINHFFCD IAPWIALACTNTQAVELVAFVIAVVVILSSCLITFVSYVYIISTILRIPSASGRSKAFST CSSHLTVVLIWYGSTVFLHVRTSIKDALDLIKAVHVLNTVVTPVLNPFIYTLRNKEVRET LLKKWKGK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | A/G | F/L | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | C/G | V/V | 1000GP (YRI, YRI, YRI) |
| 1 | 247,712,012 | 247,712,012 | SYN | C/A | V/V | 1000GP (CEU) |
| 1 | 247,712,113 | 247,712,113 | NS | A/G | F/L | 1000GP (CEU, CHBJPT) |
| 1 | 247,712,281 | 247,712,281 | NS | G/C | P/A | 1000GP (CEU) |
| 1 | 247,712,306 | 247,712,306 | SYN | C/G | V/V | 1000GP (CEU, CHBJPT) |
| 1 | 247,712,387 | 247,712,387 | SYN | A/G | C/C | 1000GP (CEU, CHBJPT) |
| 1 | 247,712,673 | 247,712,673 | NS | A/G | F/S | 1000GP (CEU) |
| 1 | 247,875,313 | 247,875,313 | NS | G/A | L/F | rs61730474 (DbSNP) |
| 1 | 247,875,314 | 247,875,314 | SYN | A/C | V/V | rs41268353 (DbSNP) |
| 1 | 247,875,347 | 247,875,347 | SYN | G/T | A/A | rs61857829 (DbSNP) |
| 1 | 247,875,415 | 247,875,415 | NS | G/A | L/F | rs2282316 (DbSNP) |
| 1 | 247,875,543 | 247,875,543 | NS | T/C | H/R | rs61730473 (DbSNP) |
| 1 | 247,875,583 | 247,875,583 | NS | C/G | A/P | rs6665599 (DbSNP) |
| 1 | 247,875,608 | 247,875,608 | SYN | C/G | V/V | rs6587382 (DbSNP) |
| 1 | 247,875,623 | 247,875,623 | SYN | G/A | A/A | rs61730472 (DbSNP) |
| 1 | 247,875,682 | 247,875,682 | NS | T/C | I/V | rs61730471 (DbSNP) |
| 1 | 247,875,689 | 247,875,689 | SYN | A/G | C/C | rs7512807 (DbSNP) |
| 1 | 247,875,975 | 247,875,975 | NS | A/G | F/S | rs61730470 (DbSNP) |
| 1 | 247,876,020 | 247,876,020 | NS | A/G | L/P | rs60303431 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 247,850,055 | 247,877,345 | CopyNumber | Variation_34793 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L249F | F215L | I181T | R172H | P159A | V154M | F62L | F28S | L13P | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | F | I | R | P | V | F | F | L | 61.98 | 0.106 |
| 2 | L | L | I | R | P | V | F | F | L | 20.05 | 0.106 |
| 3 | L | L | I | R | A | V | F | F | L | 6.61 | 0.106 |
| 4 | L | L | I | R | A | V | F | S | L | 4.38 | 0.106 |
| 5 | L | L | I | R | A | V | F | F | P | 2.07 | 0.106 |
| 6 | L | F | I | R | A | V | F | S | L | 1.46 | 0.106 |
| 7 | L | L | I | R | A | M | F | F | L | 1.31 | 0.106 |
| 8 | L | F | I | R | P | V | F | S | L | 0.69 | 0.106 |
| 9 | L | L | I | H | P | V | F | F | L | 0.61 | 0.106 |
| 10 | F | F | I | R | P | V | F | F | L | 0.46 | 0.106 |
| 11 | L | F | I | R | P | V | L | F | L | 0.15 | 0.106 |
| 12 | L | F | T | R | P | V | F | F | L | 0.08 | 0.106 |
| 13 | L | F | T | R | A | V | F | S | L | 0.08 | 0.106 |
| 14 | F | L | I | R | P | V | F | F | L | 0.08 | 0.106 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5AX1andOR6F1.aApr07 | main_exon | 3UTR | chr1 | 247,711,539 | 247,711,832 | - |
| CDS_partial | chr1 | 247,711,832 | 247,712,067 | - | ||
| exon_5UTR | chr1 | 247,734,219 | 247,734,425 | - | ||
| exon_5UTR | chr1 | 247,735,484 | 247,735,556 | - | ||
| exon_5UTR | chr1 | 247,747,871 | 247,748,140 | - | ||
| OR5AX1andOR6F1.bApr07-unspliced | main_exon | 3UTR | chr1 | 247,711,815 | 247,711,832 | - |
| CDS | chr1 | 247,711,832 | 247,712,755 | - | ||
| OR5AX1andOR6F1.fApr07 | main_exon | CDS_partial | chr1 | 247,711,947 | 247,712,087 | - |
| exon_5UTR | chr1 | 247,713,891 | 247,713,954 | - | ||
| exon_5UTR | chr1 | 247,723,651 | 247,723,764 | - | ||