OR6Q1 Olfactory Receptor
| Gene Symbol | OR6Q11 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | Q |
| Pseudogene | No |
| CORP pseudogene probability score | 0.07 (functional) |
| Aliases | OR11-226, HsOR11.12.3, ORL3427 |
| External Ids | HGNC: 15302 GeneBank: AB065737, AF399609, BK004291, NM_001005186 ORDB: ORL3427 |
| Build #39 labels | OR6Q1 |
| Chromosomal location | 11:58,030,953-58,031,903 (+) |
| Cluster | 11@58 |
| Synteny | CLIC#27 |
| Remarks | Segregating Pseudo Gene, a polymorphism of C->del at position 685 |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6A2 | 50% | 298 |
| OR6B1 | 49.5% | 303 |
| OR6N1 | 48.51% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6B1 | 50% | 303 |
| Mouse | Or6aa1 | 50% | 305 |
| Rat | Or6ae1 | 51% | 309 |
| Cow | OR11L1 | 51% | 308 |
| Orang | OR11L1 | 49% | 308 |
| Horse | OR6Q3 | 79% | 278 |
| Chimp | OR6B1P | 50% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC151146 |
| GNF Atlas2 | gnf1h10938_at |
Sequence information
| Nucleotide sequence |
ATGCAACCATATACCAAAAACTGGACCCAGGTAACTGAATTTGTCATGATGGGCTTTGCT GGCATCCATGAAGCACACCTCCTCTTCTTCATACTCTTCCTCACCATGTACCTGTTCACC TTGGTGGAGAATTTGGCCATCATTTTAGTGGTGGGTTTGGACCACCGACTACGGAGACCC ATGTATTTCTTCCTGACACACTTGTCCTGCCTTGAAATCTGGTACACTTCTGTTACAGTG CCCAAGATGCTGGCTGGTTTTATTGGGGTGGATGGTGGCAAGAATATCTCTTATGCTGAT TGCCTATCCCAGCTCTTCATCTTCACCTTTCTTGGGGCAACTGAGTGTTTCCTACTGGCT GCCATGGCCTATGATCGTTATGTGGCCATTTGTATGCCTCTCCACTATGGGGCTTTTGTG TCCTGGGGCACCTGCATCCGTCTGGCAGCTGCCTGTTGGCTGGTAGGTTTCCTCACACCC ATCTTGCCAATCTACCTCTTGTCTCAGCTAACATTTTATGGCCCAAATGTCATTGACCAT TTCTCCTGTGATGCCTCACCCTTGCTAGCCTTGTCGTGCTCAGATGTCACTTGGAAGGAG ACTGTGGATTTCCTGGTGTCTCTGGCTGTGCTACTGGCCTCCTCTATGGTCATTGCTGTG TCCTATGGCAACATCGTCTGGACACTGCTGCACATCCGCTCAGCTGCTGAGCGCTGGAAG GCCTTCTCTACCTGTGCAGCTCACCTGACTGTGGTGAGCCTCTTCTATGGCACTCTTTTC TTTATGTATGTCCAGACCAAGGTGACCTCCTCCATCAACTTCAACAAGGTGGTATCTGTC TTCTACTCTGTTGTCACGCCCATGCTCAATCCTCTCATCTACAGTCTTAGGAACAAGGAA GTGAAGGGAGCTCTGGGTCGAGTCTTTTCTCTCAACTTTTGGAAGGGACAG |
| Conceptual translation |
MQPYTKNWTQVTEFVMMGFAGIHEAHLLFFILFLTMYLFTLVENLAIILVVGLDHRLRRP MYFFLTHLSCLEIWYTSVTVPKMLAGFIGVDGGKNISYADCLSQLFIFTFLGATECFLLA AMAYDRYVAICMPLHYGAFVSWGTCIRLAAACWLVGFLTPILPIYLLSQLTFYGPNVIDH FSCDASPLLALSCSDVTWKETVDFLVSLAVLLASSMVIAVSYGNIVWTLLHIRSAAERWK AFSTCAAHLTVVSLFYGTLFFMYVQTKVTSSINFNKVVSVFYSVVTPMLNPLIYSLRNKE VKGALGRVFSLNFWKGQ Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | G/C | K/N | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | C/T | S/S | 1000GP (YRI) |
| 11 | 57,798,686 | 57,798,686 | NS | A/T | I/F | rs61741314 (DbSNP) |
| 11 | 57,798,723 | 57,798,723 | NS | A/G | D/G | rs921135 (DbSNP) |
| 11 | 57,798,801 | 57,798,801 | NS | A/G | H/R | rs61739978 (DbSNP) |
| 11 | 57,798,923 | 57,798,923 | NS | A/T | M/L | rs61748337 (DbSNP) |
| 11 | 57,798,942 | 57,798,942 | NS | A/G | Y/C | rs2513726 (DbSNP) |
| 11 | 57,799,109 | 57,799,109 | Del(1) | -/C | rs34846253 (DbSNP) | |
| 11 | 57,799,183 | 57,799,183 | SYN | C/T | S/S | rs7123727 (DbSNP) |
| 11 | 57,799,371 | 57,799,371 | NS | C/G | A/G | rs1374570 (DbSNP) |
| 11 | 58,031,031 | 58,031,031 | NS | C/T | L/F | 1000GP (CEU) |
| 11 | 58,031,251 | 58,031,251 | NS | A/G | D/G | 1000GP (CEU, CHBJPT) |
| 11 | 58,031,326 | 58,031,326 | NS | A/T | D/V | 1000GP (CHBJPT) |
| 11 | 58,031,470 | 58,031,470 | NS | A/G | Y/C | 1000GP (CEU, CHBJPT) |
| 11 | 58,031,711 | 58,031,711 | SYN | C/T | S/S | 1000GP (CEU, CHBJPT) |
| 11 | 58,031,899 | 58,031,899 | NS | G/C | G/A | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 57,798,325 | 57,801,375 | CopyNumber | #70 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L27F | K82N | D100G | D125V | L167M | Y173C | A190T | G316A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | K | D | D | L | Y | A | A | 46.62 | 0.088 |
| 2 | L | K | G | D | L | C | A | G | 36.18 | 0.088 |
| 3 | L | K | D | D | L | Y | A | G | 14.44 | 0.088 |
| 4 | L | K | G | V | L | C | A | G | 1.15 | 1.000 |
| 5 | L | K | G | D | L | C | T | G | 0.38 | 0.088 |
| 6 | F | K | D | D | L | Y | A | A | 0.31 | 0.088 |
| 7 | L | K | G | D | L | Y | A | G | 0.31 | 0.088 |
| 8 | L | K | D | D | M | Y | A | A | 0.23 | 0.088 |
| 9 | L | N | D | D | L | Y | A | G | 0.23 | 0.088 |
| 10 | L | K | G | D | L | C | A | A | 0.08 | 0.088 |
| 11 | L | K | D | D | L | C | A | G | 0.08 | 0.088 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6Q1.aApr07-unspliced | main_exon | CDS | chr11 | 58,030,953 | 58,031,903 | + |
| 3UTR | chr11 | 58,031,903 | 58,031,906 | + | ||