OR7A5 Olfactory Receptor
| Gene Symbol | OR7A51 (View this gene in GeneCards) |
| Family | 7 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | HTPCR2, OR19-17, HsOR19.3.2, ORL214, ORL230 |
| External Ids | HGNC: 8368 GeneBank: AF399543, BK004221, HSHTPRH04, HSTPCR92P ORDB: ORL214, ORL230 |
| Build #39 labels | OR7A5 |
| Chromosomal location | 19:14,827,285-14,828,241 (-) |
| Cluster | 19@15a |
| Synteny | CLIC#45 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR7A10 | 81.4% | 301 |
| OR7A17 | 81.73% | 301 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR7A26 | 76% | 319 |
| Mouse | Or7a40 | 76% | 301 |
| Rat | Or7a41 | 72% | 320 |
| Cow | OR7A65 | 76% | 310 |
| Orang | OR7A10D | 78% | 322 |
| Orang | OR7A10 | 81% | 301 |
| Horse | OR7A96 | 79% | 311 |
| Chimp | OR7A10 | 81% | 301 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BP370465 |
| mRNA | X64976 |
| GNF Atlas2 | 208285_at |
Sequence information
| Nucleotide sequence |
ATGGAACCAGGAAATGATACACAAATTTCAGAATTTCTTCTTCTGGGATTTTCACAAGAA CCTGGACTGCAACCCTTCCTCTTTGGGCTGTTCCTGTCCATGTACCTGGTCACTGTGCTC GGGAACCTGCTCATCATCCTGGCCACAATCTCAGACTCCCACCTCCACACCCCCATGTAC TTCTTCCTCTCCAACCTGTCCTTTGCTGACATTTGTGTTACTTCCACCACCATTCCAAAA ATGCTGATGAACATCCAGACACAGAACAAAGTCATCACCTACATAGCCTGCCTCATGCAG ATGTATTTTTTCATACTCTTTGCTGGATTTGAAAACTTCCTCCTGTCCGTGATGGCCTAT GACCGGTTTGTGGCCATCTGTCACCCCCTGCACTACATGGTCATTATGAACCCTCACCTC TGTGGACTGCTGGTTCTAGCATCCTGGACCATGAGTGCTCTGTATTCCTTGCTACAAATC TTAATGGTAGTACGGCTGTCCTTCTGCACAGCCTTAGAAATCCCCCACTTTTTCTGTGAA CTTAATCAGGTCATCCAACTTGCTTGTTCTGATAGCTTTCTTAATCACATGGTGATATAT TTTACAGTTGCGCTGCTGGGTGGAGGTCCCCTGACTGGGATCCTTTACTCTTACTCTAAG ATAATTTCTTCCATACATGCAATCTCATCAGCTCAGGGGAAGTACAAGGCATTTTCCACC TGTGCATCTCACCTCTCAGTTGTCTCCTTATTTTATGGTGCAATCCTAGGGGTGTACCTT AGTTCTGCTGCCACCCGCAACTCACACTCAAGTGCAACAGCCTCAGTGATGTACACTGTG GTCACCCCCATGCTGAACCCCTTTATCTATAGTCTGAGGAATAAAGACATAAAGAGGGCT CTGGGAATACATTTGTTGTGGGGAACAATGAAAGGGCAATTTTTCAAGAAGTGCCCA |
| Conceptual translation |
MEPGNDTQISEFLLLGFSQEPGLQPFLFGLFLSMYLVTVLGNLLIILATISDSHLHTPMY FFLSNLSFADICVTSTTIPKMLMNIQTQNKVITYIACLMQMYFFILFAGFENFLLSVMAY DRFVAICHPLHYMVIMNPHLCGLLVLASWTMSALYSLLQILMVVRLSFCTALEIPHFFCE LNQVIQLACSDSFLNHMVIYFTVALLGGGPLTGILYSYSKIISSIHAISSAQGKYKAFST CASHLSVVSLFYGAILGVYLSSAATRNSHSSATASVMYTVVTPMLNPFIYSLRNKDIKRA LGIHLLWGTMKGQFFKKCP Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 19 | 100 | -100 | NS | T/A | H/L | 1000GP (YRI, YRI, YRI) |
| 19 | 100 | -100 | SYN | T/C | L/L | 1000GP (YRI) |
| 19 | 14,827,804 | 14,827,804 | SYN | T/C | L/L | 1000GP (CEU, CHBJPT) |
| 19 | 14,938,190 | 14,938,190 | SYN | A/G | F/F | rs2240561 (DbSNP) |
| 19 | 14,938,278 | 14,938,278 | NS | T/C | Y/C | rs61731997 (DbSNP) |
| 19 | 14,938,300 | 14,938,300 | NS | A/T | Y/N | rs62122651 (DbSNP) |
| 19 | 14,938,412 | 14,938,412 | NS | C/G | M/I | rs61731998 (DbSNP) |
| 19 | 14,938,421 | 14,938,421 | SYN | C/G | L/L | rs62122652 (DbSNP) |
| 19 | 14,938,537 | 14,938,537 | NS | C/T | E/K | rs56284724 (DbSNP) |
| 19 | 14,938,616 | 14,938,616 | SYN | C/T | L/L | rs2190686 (DbSNP) |
| 19 | 14,938,860 | 14,938,860 | NS | T/C | N/S | rs61731995 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 19 | 14,936,097 | 14,939,153 | CopyNumber | #130 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A300V | T282S | I214M | A204V | E173K | R122W | G41R | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A | T | I | A | E | R | G | 95.39 | 0.078 |
| 2 | A | T | I | A | K | R | G | 2.38 | 0.078 |
| 3 | A | T | M | A | E | R | G | 0.84 | 0.078 |
| 4 | V | T | I | A | E | R | G | 0.69 | 0.078 |
| 5 | A | T | I | A | E | R | R | 0.31 | 0.078 |
| 6 | A | T | I | A | E | W | G | 0.15 | 0.602 |
| 7 | A | S | I | A | E | R | G | 0.08 | 0.078 |
| 8 | A | T | I | V | E | R | G | 0.08 | 0.078 |
| 9 | V | T | M | A | E | R | G | 0.08 | 0.078 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR7A5andOR7C1.bApr07-unspliced | main_exon | 3UTR | chr19 | 14,826,327 | 14,827,285 | - |
| CDS | chr19 | 14,827,285 | 14,828,241 | - | ||
| 5UTR | chr19 | 14,828,241 | 14,828,464 | - | ||
| OR7A5andOR7C1.cApr07 | main_exon | CDS_partial | chr19 | 14,827,764 | 14,828,241 | - |
| 5UTR | chr19 | 14,828,241 | 14,828,254 | - | ||
| exon_5UTR | chr19 | 14,835,074 | 14,835,148 | - | ||