OR8B4 Olfactory Receptor
| Gene Symbol | OR8B41 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-315, AC002556-D, HsOR11.18.35, ORL3423 |
| External Ids | HGNC: 8473 GeneBank: AB065831, AF399509, BK004205, NM_001005196 ORDB: ORL3423 |
| Build #39 labels | OR8B4 |
| Chromosomal location | 11:124,423,945-124,424,871 (-) |
| Cluster | 11@124 |
| Synteny | CLIC#29 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs4057749) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8B1P | 72.19% | 302 |
| OR8B3 | 68.18% | 308 |
| OR8C1P | 67.21% | 308 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8B1L | 72% | 306 |
| Mouse | Or8b4 | 86% | 309 |
| Rat | Or8b4 | 84% | 309 |
| Cow | OR8B1S | 70% | 310 |
| Orang | OR8B1P | 71% | 307 |
| Horse | OR8B1X | 70% | 309 |
| Chimp | OR8B4P | 95% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136865 |
| GNF Atlas2 | gnf1h11319_at |
Sequence information
| Nucleotide sequence |
ATGACTCTGAGAAACAGCTCCTCAGTGACTGAGTTTATCCTTGTGGGATTATCAGAACAG CCAGAGCTCCAGCTCCCTCTTTTCCTTCTATTCTTAGGGATCTATGTGTTCACTGTGGTG GGCAACTTGGGCTTGATCACCTTAATTGGGATAAATCCTAGCCTTCACACCCCCATGTAC TTTTTCCTCTTCAACTTGTCCTTTATAGATCTCTGTTATTCCTGTGTGTTTACCCCCAAA ATGCTGAATGACTTTGTTTCAGAAAGTATCATCTCTTATGTGGGATGTATGACTCAGCTA TTTTTCTTCTGTTTCTTTGTCAATTCTGAGTGCTATGTGTTGGTATCAATGGCCTATGAT CGCTATGTGGCCATCTGCAACCCCCTGCTCTACATGGTCACCATGTCCCCAAGGGTCTGC TTTCTGCTGATGTTTGGTTCCTATGTGGTAGGGTTTGCTGGGGCCATGGCCCACACTGGA AGCATGCTGCGACTGACCTTCTGTGATTCCAACGTCATTGACCATTATCTGTGTGACGTT CTCCCCCTCTTGCAGCTCTCCTGCACCAGCACCCATGTCAGTGAGCTGGTATTTTTCATT GTTGTTGGAGTAATCACCATGCTATCCAGCATAAGCATCGTCATCTCTTACGCTTTGATA CTCTCCAACATCCTCTGTATTCCTTCTGCAGAGGGCAGATCCAAAGCCTTTAGCACATGG GGCTCCCACATAATTGCTGTTGCTCTGTTTTTTGGGTCAGGGACATTCACCTACTTAACA ACATCTTTTCCTGGCTCTATGAACCATGGCAGATTTGCCTCAGTCTTTTACACCAATGTG GTTCCCATGCTTAACCCTTCGATCTACAGTTTGAGGAATAAGGATGATAAACTTGCCCTG GGCAAAACCCTGAAGAGAGTGCTCTTC |
| Conceptual translation |
MTLRNSSSVTEFILVGLSEQPELQLPLFLLFLGIYVFTVVGNLGLITLIGINPSLHTPMY FFLFNLSFIDLCYSCVFTPKMLNDFVSESIISYVGCMTQLFFFCFFVNSECYVLVSMAYD RYVAICNPLLYMVTMSPRVCFLLMFGSYVVGFAGAMAHTGSMLRLTFCDSNVIDHYLCDV LPLLQLSCTSTHVSELVFFIVVGVITMLSSISIVISYALILSNILCIPSAEGRSKAFSTW GSHIIAVALFFGSGTFTYLTTSFPGSMNHGRFASVFYTNVVPMLNPSIYSLRNKDDKLAL GKTLKRVLF Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | A/G | C/R | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | A/C | V/V | 1000GP (YRI) |
| 11 | 124,294,213 | 124,294,213 | NS | C/A | Q/H | rs61736181 (DbSNP) |
| 11 | 124,294,231 | 124,294,231 | NS | C/G | E/D | rs61736191 (DbSNP) |
| 11 | 124,294,236 | 124,294,236 | NS | A/G | C/R | rs4057749 (DbSNP) |
| 11 | 124,294,327 | 124,294,326 | Ins(1) | -/G | rs36005108 (DbSNP) | |
| 11 | 124,294,349 | 124,294,349 | NS | A/C | F/C | rs7116575 (DbSNP) |
| 11 | 124,294,377 | 124,294,377 | NS | A/G | Y/H | rs4057750 (DbSNP) |
| 11 | 124,294,703 | 124,294,703 | NS | C/T | G/E | rs10750270 (DbSNP) |
| 11 | 124,424,340 | 124,424,340 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 11 | 124,424,353 | 124,424,353 | NS | A/C | I/M | 1000GP (CHBJPT) |
| 11 | 124,424,453 | 124,424,453 | NS | C/A | C/F | 1000GP (CEU, CHBJPT) |
| 11 | 124,424,481 | 124,424,481 | NS | A/G | Y/H | 1000GP (CEU, CHBJPT) |
| 11 | 124,424,807 | 124,424,807 | NS | T/C | E/G | 1000GP (CEU, CHBJPT) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L304R | A248V | Q185H | C178R | I173M | C140F | Y131H | E22G | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | A | Q | C | I | C | Y | G | 36.48 | 0.334 |
| 2 | L | A | Q | C | I | C | Y | E | 33.64 | 0.334 |
| 3 | L | A | Q | R | I | F | H | E | 16.67 | 1.000 |
| 4 | L | A | Q | R | I | C | H | E | 9.45 | 1.000 |
| 5 | L | A | Q | R | I | C | Y | E | 2.15 | 0.680 |
| 6 | L | A | H | C | I | C | Y | E | 1.00 | 0.334 |
| 7 | R | A | Q | C | I | C | Y | G | 0.23 | 0.334 |
| 8 | L | A | Q | R | M | F | H | E | 0.15 | 1.000 |
| 9 | L | A | H | C | I | C | Y | G | 0.08 | 0.334 |
| 10 | L | V | Q | C | I | C | Y | E | 0.08 | 0.334 |
| 11 | L | A | Q | R | I | F | H | G | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8B4.aApr07-unspliced | main_exon | 3UTR | chr11 | 124,423,942 | 124,423,945 | - |
| CDS | chr11 | 124,423,945 | 124,424,871 | - | ||