OR8K3 Olfactory Receptor
| Gene Symbol | OR8K31 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | K |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-181, HsOR11.11.59, ORL3385 |
| External Ids | HGNC: 15313 GeneBank: AB065541, BK004338, NM_001005202 ORDB: ORL3385 |
| Build #39 labels | OR8K3 |
| Chromosomal location | 11:56,318,307-56,319,242 (+) |
| Cluster | 11@56 |
| Synteny | CLIC#26 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs960193) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8K1 | 68.83% | 308 |
| OR8K5 | 70.03% | 307 |
| OR8V1P | 74.19% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8K87 | 81% | 307 |
| Mouse | Or8k3b | 81% | 311 |
| Rat | Or8k3b-ps | 81% | 311 |
| Cow | OR8K3B | 79% | 312 |
| Orang | OR5G1 | 54% | 307 |
| Horse | OR8K3BP | 84% | 312 |
| Horse | OR8K79P | 81% | 312 |
| Horse | OR8K72 | 82% | 307 |
| Chimp | OR8K6 | 75% | 306 |
Sequence information
| Nucleotide sequence |
ATGGAACAACACAATCTAACAACGGTGAATGAATTCATTCTTACGGGAATCACAGATATC GCTGAGCTGCAGGCACCATTATTTGCATTGTTCCTCATGATCTATGTGATCTCAGTGATG GGCAATTTGGGCATGATTGTCCTCACCAAGTTGGACTCCAGGTTGCAAACCCCTATGTAC TTTTTTCTCAGACATCTGGCTTTCATGGATCTTGGTTATTCAACAACTGTGGGACCCAAA ATGTTAGTAAATTTTGTTGTGGATAAGAATATAATTTCTTATTATTTTTGTGCAACACAG CTAGCTTTCTTTCTTGTGTTCATTGGTAGTGAACTTTTTATTCTCTCAGCCATGTCCTAC GACCTCTATGTGGCCATCTGTAACCCTCTGCTATACACAGTAATCATGTCACGAAGGGTA TGTCAGGTGCTGGTAGCAATCCCTTACCTCTATTGCACATTCATTTCTCTTCTAGTCACC ATAAAGATTTTTACTTTATCCTTCTGTGGCTACAACGTCATTAGTCATTTCTACTGTGAC AGTCTCCCTTTGTTACCTTTGCTTTGTTCAAATACACATGAAATTGAATTGATAATTCTG ATCTTTGCAGCTATTGATTTGATTTCATCTCTTCTGATAGTTCTTTTATCTTACCTGCTC ATCCTTGTAGCCATTCTCAGGATGAATTCTGCTGGCAGACAAAAGGCTTTTTCTACCTGT GGAGCCCACCTGACAGTGGTCATAGTGTTCTATGGGACTTTGCTTTTCATGTACGTGCAG CCCAAGTCCAGTCATTCCTTTGACACTGATAAAGTGGCTTCCATATTTTACACCCTGGTT ATCCCCATGTTGAATCCCTTGATCTATAGTTTACGAAACAAAGATGTAAAATATGCCCTA CGAAGGACATGGAATAACTTATGTAATATTTTTGTT |
| Conceptual translation |
MEQHNLTTVNEFILTGITDIAELQAPLFALFLMIYVISVMGNLGMIVLTKLDSRLQTPMY FFLRHLAFMDLGYSTTVGPKMLVNFVVDKNIISYYFCATQLAFFLVFIGSELFILSAMSY DLYVAICNPLLYTVIMSRRVCQVLVAIPYLYCTFISLLVTIKIFTLSFCGYNVISHFYCD SLPLLPLLCSNTHEIELIILIFAAIDLISSLLIVLLSYLLILVAILRMNSAGRQKAFSTC GAHLTVVIVFYGTLLFMYVQPKSSHSFDTDKVASIFYTLVIPMLNPLIYSLRNKDVKYAL RRTWNNLCNIFV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | T/G | L/R | 1000GP (YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | Y/Y | 1000GP (YRI) |
| 11 | 56,086,147 | 56,086,147 | NS | T/G | L/R | rs960193 (DbSNP) |
| 11 | 56,086,299 | 56,086,299 | NS | A/G | I/V | rs12291617 (DbSNP) |
| 11 | 56,086,607 | 56,086,607 | NS | A/G | I/M | rs17150317 (DbSNP) |
| 11 | 56,318,671 | 56,318,671 | NS | T/G | L/R | 1000GP (CEU, CHBJPT) |
| 11 | 56,318,864 | 56,318,864 | SYN | T/C | P/P | 1000GP (CEU) |
| 11 | 56,319,084 | 56,319,084 | nonsense SNP | C/T | Q/* | 1000GP (CEU) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L122R | V173I | Q260* | I275M | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | R | V | Q | I | 71.20 | 0.078 |
| 2 | L | V | Q | I | 25.12 | 0.602 |
| 3 | R | I | Q | I | 2.15 | 0.078 |
| 4 | R | V | * | I | 0.84 | 1.200 |
| 5 | R | I | Q | M | 0.69 | 0.078 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8K3.aApr07-unspliced | main_exon | CDS | chr11 | 56,318,307 | 56,319,242 | + |
| 3UTR | chr11 | 56,319,242 | 56,319,245 | + | ||