OR8S1 Olfactory Receptor
| Gene Symbol | OR8S11 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | S |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | HsOR12.3.6 |
| External Ids | HGNC: 19628 GeneBank: NM_001005203 |
| Build #39 labels | OR8S1 |
| Chromosomal location | 12:48,525,632-48,526,567 (+) |
| Cluster | 12@49b |
| Synteny | CLIC#30 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8T1P | 69.54% | 302 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8S13 | 73% | 311 |
| Mouse | Or8s2 | 71% | 304 |
| Rat | Or8s10 | 69% | 307 |
| Cow | OR8S15 | 71% | 312 |
| Orang | OR8S2 | 72% | 302 |
| Horse | OR8S2 | 72% | 303 |
| Chimp | OR8S1P | 95% | 273 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h02608_at |
Sequence information
| Nucleotide sequence |
ATGGCCTTGGGGAATCACAGCACCATCACCGAGTTCCTCCTCCTTGGGCTGTCTGCCGAC CCCAACATCCGGGCTCTGCTCTTTGTGCTGTTCCTGGGGATTTACCTCCTGACCATAATG GAAAACCTGATGCTGCTGCTCATGATCAGGGCTGATTCTTGTCTCCATAAGCCCATGTAT TTCTTCCTGAGTCACCTCTCTTTTGTTGATCTCTGCTTCTCTTCAGTCATTGTGCCCAAG ATGCTGGAGAACCTCCTGTCACAGAGGAAAACCATTTCAGTAGAGGGCTGCCTGGCTCAG GTCTTCTTTGTGTTTGTCACTGCAGGGACTGAAGCCTGCCTTCTCTCAGGGATGGCCTAT GACCGCCATGCTGCCATCTGCCGCCCACTACTTTATGGACAGATCATGGGTAAACAGCTG TATATGCACCTTGTGTGGGGCTCATGGGGACTGGGCTTTCTGGACGCACTCATCAATGTC CTCCTAGCTGTAAACATGGTCTTTTGTGAAGCCAAAATCATTCACCACTACAGCTATGAG ATGCCATCCCTCCTCCCTCTGTCCTGCTCTGATATCTCCAGAAGCCTCATCGCCTTGCTC TGCTCCACTCTCCTACATGGGCTGGGAAACTTCCTTTTGGTCTTCTTATCCTACACCCGT ATAATCTCTACCATCCTAAGCATCAGCTCTACCTCGGGCAGAAGCAAGGCCTTCTCCACC TGCTCTGCCCACCTCACTGCAGTGACACTTTACTATGGCTCAGGTTTGCTCCGCCATCTC ATGCCAAACTCAGGTTCCCCCATAGAGTTGATCTTCTCTGTGCAGTATACTGTAGTCACT CCCATGCTGAATTCCCTCATCTATAGCCTGAAAAATAAGGAAGTGAAGGTAGCTCTGAAA AGAACTTTGGAAAAATATTTGCAATATACCAGACGT |
| Conceptual translation |
MALGNHSTITEFLLLGLSADPNIRALLFVLFLGIYLLTIMENLMLLLMIRADSCLHKPMY FFLSHLSFVDLCFSSVIVPKMLENLLSQRKTISVEGCLAQVFFVFVTAGTEACLLSGMAY DRHAAICRPLLYGQIMGKQLYMHLVWGSWGLGFLDALINVLLAVNMVFCEAKIIHHYSYE MPSLLPLSCSDISRSLIALLCSTLLHGLGNFLLVFLSYTRIISTILSISSTSGRSKAFST CSAHLTAVTLYYGSGLLRHLMPNSGSPIELIFSVQYTVVTPMLNSLIYSLKNKEVKVALK RTLEKYLQYTRR Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | NS | A/G | N/S | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | G/A | L/L | 1000GP (YRI) |
| 12 | 48,525,773 | 48,525,773 | NS | A/G | M/V | 1000GP (CEU, CHBJPT) |
| 12 | 48,525,876 | 48,525,876 | NS | T/C | L/P | 1000GP (CEU, CHBJPT) |
| 12 | 48,525,877 | 48,525,877 | SYN | G/A | L/L | 1000GP (CEU, CHBJPT) |
| 12 | 48,526,010 | 48,526,010 | NS | T/C | C/R | 1000GP (CEU, CHBJPT) |
| 12 | 48,526,013 | 48,526,013 | NS | C/T | R/C | 1000GP (CEU, CHBJPT) |
| 12 | 48,526,108 | 48,526,108 | SYN | T/C | N/N | 1000GP (CHBJPT) |
| 12 | 48,526,223 | 48,526,223 | NS | G/A | A/T | 1000GP (CEU, CHBJPT) |
| 12 | 48,526,290 | 48,526,290 | NS | G/A | R/H | 1000GP (CEU, CHBJPT) |
| 12 | 48,919,556 | 48,919,556 | NS | A/G | M/V | rs2731073 (DbSNP) |
| 12 | 48,919,659 | 48,919,659 | NS | T/C | L/P | rs4075258 (DbSNP) |
| 12 | 48,919,659 | 48,919,660 | mnp | CA/TG | rs71439450 (DbSNP) | |
| 12 | 48,919,660 | 48,919,660 | SYN | A/G | L/L | rs35367885 (DbSNP) |
| 12 | 48,919,778 | 48,919,778 | NS | T/C | C/R | rs4075259 (DbSNP) |
| 12 | 48,919,793 | 48,919,793 | NS | T/C | C/R | rs2705143 (DbSNP) |
| 12 | 48,919,796 | 48,919,796 | NS | C/T | R/C | rs12425460 (DbSNP) |
| 12 | 48,920,006 | 48,920,006 | NS | A/G | T/A | rs12425518 (DbSNP) |
| 12 | 48,920,073 | 48,920,073 | NS | A/G | H/R | rs61941963 (DbSNP) |
| 12 | 48,920,261 | 48,920,261 | NS | C/G | L/V | rs59116841 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 226 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| N5S | E11K | M48V | L82P | C127R | A198T | R220H | I268T | L283V | R312H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N | E | V | P | C | T | R | I | L | R | 28.65 | 0.837 |
| 2 | N | E | V | P | C | A | R | I | L | R | 28.11 | 0.837 |
| 3 | N | E | V | L | R | A | R | I | L | R | 21.04 | 0.872 |
| 4 | N | E | V | L | C | A | H | I | L | R | 9.98 | 0.872 |
| 5 | N | E | M | L | C | A | R | I | L | R | 7.76 | 0.872 |
| 6 | N | E | V | L | C | A | R | I | L | R | 2.15 | 0.872 |
| 7 | S | E | V | P | C | T | R | I | L | R | 0.92 | 0.837 |
| 8 | N | E | V | P | C | A | R | I | V | R | 0.54 | 0.837 |
| 9 | N | E | V | L | R | A | R | I | L | H | 0.15 | 0.872 |
| 10 | N | E | V | L | C | T | R | I | L | R | 0.15 | 0.872 |
| 11 | N | E | V | L | R | A | H | I | L | R | 0.15 | 0.872 |
| 12 | N | E | V | L | R | A | R | T | L | R | 0.08 | 0.872 |
| 13 | N | E | V | P | C | T | R | T | L | R | 0.08 | 0.837 |
| 14 | N | E | V | L | C | A | R | I | L | H | 0.08 | 0.872 |
| 15 | N | E | M | P | C | T | R | I | L | R | 0.08 | 0.837 |
| 16 | N | K | V | P | C | T | R | I | L | R | 0.08 | 0.837 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8S1.aApr07 | exon_3UTR | chr12 | 48,527,912 | 48,528,103 | + | |