Protein information for: OR4C12



MEKKKNVTEFILIGLTQNPIMEKVTFVVFLVLYMITLSGNLLIVVTITTS
QALSSPMYFFLTHLSLIDTVYSSSSAPKLIVDSFQEKKIISFNGCMAQAY
AEHIFGATEIILLTVMACDCYVAICKPLNYTTIMSHSLCILLVAVAWVGG
FLHATIQILFTVWLPFCGPNVIGHFMCDLYPLLKLVCIDTHTLGLFVAVN
SGFICLLNFLILVVSYVIILRSLKNNSLEGRCKALSTCISHIIVVVLFFV
PCIFVYLRSVTTLPIDKAVAVFYTMVVPMLNPVVYTLRNAEVKSAIRKLW
RKKVTSDND
In red: predicted N-glycosylation site.
In magenta: Conserved cysteines that are predicted to form a disulfide bond.
Underlined and bold: TM regions.

Predicted binding site residues (CDRs) are highlighted according to the following amino acid color code:
| | basic (H,R,K)
| | hydrophilic, no charge (Q,N,T,S)
| | aliphatic (M,A,I,L,V)
| | aromatic (F,Y,W)
| | helix breakers (G,P)
| | acidic (D,E)
| | cysteine (C)

Sequences of the TM regions:

TM

Start position

End position

Sequence

TM1 22 48 EKVTFVVFLVLYMITLSGNLLIVVTIT
TM2 59 81 FFLTHLSLIDTVYSSSSAPKLIV
TM3 96 116 MAQAYAEHIFGATEIILLTVM
TM4 139 159 CILLVAVAWVGGFLHATIQIL
TM5 196 217 FVAVNSGFICLLNFLILVVSYV
TM6 238 262 CISHIIVVVLFFVPCIFVYLRSVTT
TM7 267 284 AVAVFYTMVVPMLNPVVY

The information was derived from a multiple alignment of ORs, based on the algorithms of Man et al. Protein Sci. 2004 Jan;13(1):240-54.
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