OR1B1 Olfactory Receptor
| Gene Symbol | OR1B11 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.28 (functional) |
| Aliases | hRPK-465_F_21, OR9-26, OR9-B, HsOR9.6.9, ORL3234 |
| External Ids | HGNC: 8181 GeneBank: AB065723, BK004229, NM_001004450 ORDB: ORL3234 |
| Build #39 labels | OR1B1 |
| Chromosomal location | 9:122,628,582-122,629,535 (-) |
| Cluster | 9@125 |
| Synteny | CLIC#21 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs1476860 (AA change=R/* ) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1E1 | 46.69% | 302 |
| OR1F1 | 45.57% | 305 |
| OR1K1 | 47.1% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1K1 | 47% | 316 |
| Mouse | Or1b1 | 87% | 316 |
| Rat | Or1b1 | 85% | 317 |
| Cow | OR1E1G | 48% | 312 |
| Orang | OR1B1P | 96% | 305 |
| Orang | OR1B1BP | 94% | 310 |
| Horse | OR1B4P | 80% | 316 |
| Chimp | OR1B3P | 98% | 204 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG357707 |
| mRNA | AB529298 |
| GNF Atlas2 | gnf1h10932_at |
Sequence information
| Nucleotide sequence |
ATGATGAGCTTTGCCCCTAATGCTTCACACTCTCCGGTTTTTTTGCTCCTTGGGTTCTCG AGAGCTAACATCTCCTACACTCTCCTCTTCTTCCTGTTCCTGGCTATTTACCTGACCACC ATACTGGGGAATGTGACACTGGTGCTGCTCATCTCCTGGGACTCCAGACTGCACTCACCC ATGTATTATCTGCTTCGTGGCCTCTCTGTGATAGACATGGGGCTATCCACAGTTACACTG CCCCAGTTGCTGGCCCATTTGGTCTCTCATTACCCAACCATTCCTGCTGCCCGCTGCTTG GCTCAGTTCTTTTTCTTCTATGCATTTGGGGTTACAGATACACTTGTCATTGCTGTCATG GCTCTGGATCGCTATGTGGCCATCTGTGACCCCCTGCACTATGCTTTGGTAATGAATCAC CAACGGTGTGCCTGCTTACTAGCCTTGAGCTGGGTGGTGTCCATACTGCACACCATGTTG CGTGTGGGACTCGTCCTGCCTCTTTGCTGGACTGGGGATGCTGGGGGCAACGTTAACCTT CCTCACTTCTTTTGTGACCACCGGCCACTTCTGCGAGCCTCTTGTTCTGACATACATTCT AATGAGCTGGCCATATTCTTTGAGGGTGGCTTCCTTATGCTGGGCCCCTGTGCCCTCATT GTACTCTCTTATGTCCGAATTGGGGCCGCTATTCTACGTTTGCCTTCAGCTGCTGGTCGC CGCCGAGCAGTCTCCACCTGTGGATCCCACCTCACCATGGTTGGTTTCCTCTACGGCACC ATCATTTGTGTCTACTTCCAGCCTCCCTTCCAGAACTCTCAGTATCAGGACATGGTGGCT TCAGTAATGTATACTGCCATTACACCTTTGGCCAACCCATTTGTGTATAGCCTCCACAAT AAGGATGTCAAGGGTGCACTCTGCAGGCTGCTTGAATGGGTGAAGGTAGACCCC |
| Conceptual translation |
MMSFAPNASHSPVFLLLGFSRANISYTLLFFLFLAIYLTTILGNVTLVLLISWDSRLHSP MYYLLRGLSVIDMGLSTVTLPQLLAHLVSHYPTIPAARCLAQFFFFYAFGVTDTLVIAVM ALDRYVAICDPLHYALVMNHQRCACLLALSWVVSILHTMLRVGLVLPLCWTGDAGGNVNL PHFFCDHRPLLRASCSDIHSNELAIFFEGGFLMLGPCALIVLSYVRIGAAILRLPSAAGR RRAVSTCGSHLTMVGFLYGTIICVYFQPPFQNSQYQDMVASVMYTAITPLANPFVYSLHN KDVKGALCRLLEWVKVDP Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 9 | 100 | -100 | nonsense SNP | G/A | R/* | 1000GP (YRI, YRI) |
| 9 | 100 | -100 | NS | A/C | V/G | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 9 | 100 | -100 | SYN | G/A | F/F | 1000GP (YRI, YRI, YRI) |
| 9 | 122,628,595 | 122,628,595 | NS | A/C | V/G | 1000GP (CEU, CHBJPT) |
| 9 | 122,628,747 | 122,628,747 | NS | A/C | C/W | 1000GP (CEU, CHBJPT) |
| 9 | 122,628,848 | 122,628,848 | NS | C/T | A/T | 1000GP (CEU, CHBJPT) |
| 9 | 122,628,962 | 122,628,962 | nonsense SNP | G/A | R/* | 1000GP (CEU, CHBJPT) |
| 9 | 122,629,044 | 122,629,044 | SYN | G/A | L/L | 1000GP (CHBJPT) |
| 9 | 122,629,090 | 122,629,090 | NS | A/G | L/S | 1000GP (CEU, CHBJPT) |
| 9 | 122,629,130 | 122,629,130 | SYN | A/G | L/L | 1000GP (CEU, CHBJPT) |
| 9 | 122,629,398 | 122,629,398 | SYN | T/C | T/T | 1000GP (CEU, CHBJPT) |
| 9 | 122,629,452 | 122,629,452 | SYN | G/C | L/L | 1000GP (CEU) |
| 9 | 125,390,874 | 125,390,874 | NS | C/A | G/V | rs1556189 (DbSNP) |
| 9 | 125,391,012 | 125,391,012 | NS | C/G | R/P | rs41316978 (DbSNP) |
| 9 | 125,391,026 | 125,391,026 | NS | A/C | C/W | rs1476858 (DbSNP) |
| 9 | 125,391,127 | 125,391,127 | NS | C/T | A/T | rs1476859 (DbSNP) |
| 9 | 125,391,241 | 125,391,241 | nonsense SNP | A/G | */R | rs1476860 (DbSNP) |
| 9 | 125,391,369 | 125,391,369 | NS | G/A | S/L | rs1536929 (DbSNP) |
| 9 | 125,391,409 | 125,391,409 | SYN | G/A | L/L | rs1536928 (DbSNP) |
| 9 | 125,391,677 | 125,391,677 | SYN | C/T | T/T | rs12347681 (DbSNP) |
| 9 | 125,391,777 | 125,391,776 | Ins(1) | -/A | rs72541201 (DbSNP) | |
| 9 | 125,391,778 | 125,391,777 | Ins(1) | -/A | rs11421222 (DbSNP) | |
| 9 | 125,391,779 | 125,391,778 | Ins(1) | -/A | rs67290601 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 163 (Hasin) | |||
| 9 | 125,388,861 | 125,391,914 | Deletion | #195 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V314G | P268R | C263W | S249P | A230T | R226* | R192* | L149S | R124C | D54E | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | P | W | S | A | R | R | S | R | D | 34.41 | 0.531 |
| 2 | G | P | W | S | T | R | * | S | R | D | 20.43 | 1.200 |
| 3 | V | P | C | S | A | R | R | L | R | D | 19.35 | 0.531 |
| 4 | G | P | W | S | T | R | * | L | R | D | 10.22 | 1.200 |
| 5 | G | P | W | S | T | R | R | S | R | D | 7.83 | 0.531 |
| 6 | G | P | C | S | A | R | R | L | R | D | 5.61 | 0.531 |
| 7 | G | R | W | S | A | R | R | S | R | D | 0.54 | 0.307 |
| 8 | G | P | W | S | T | R | * | S | R | E | 0.46 | 1.200 |
| 9 | G | P | W | S | A | * | R | S | R | D | 0.15 | 1.200 |
| 10 | G | P | C | P | A | R | R | S | R | D | 0.15 | 0.158 |
| 11 | G | P | C | S | T | R | R | S | R | D | 0.15 | 0.531 |
| 12 | G | P | W | S | T | R | R | L | R | D | 0.15 | 0.531 |
| 13 | G | P | W | S | A | R | R | S | C | D | 0.08 | 0.953 |
| 14 | G | P | W | S | T | R | * | L | C | D | 0.08 | 1.200 |
| 15 | V | P | C | S | T | R | R | S | R | D | 0.08 | 0.531 |
| 16 | G | P | W | S | A | R | * | S | R | D | 0.08 | 1.200 |
| 17 | V | P | C | S | A | R | R | S | R | D | 0.08 | 0.531 |
| 18 | G | P | W | S | T | R | * | S | C | D | 0.08 | 1.200 |
| 19 | V | P | W | S | T | R | * | S | R | D | 0.08 | 1.200 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1B1.aApr07-unspliced | main_exon | 3UTR | chr9 | 122,628,579 | 122,628,582 | - |
| CDS | chr9 | 122,628,582 | 122,629,535 | - | ||