OR1S2 Olfactory Receptor
| Gene Symbol | OR1S21 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | S |
| Pseudogene | No |
| CORP pseudogene probability score | 0.72 (pseudogene) |
| Aliases | OR11-231, HsOR11.12.9, ORL3309 |
| External Ids | HGNC: 15141 GeneBank: AB065736, AF399557, BK004297, NM_001004459 ORDB: ORL3309 |
| Build #39 labels | OR1S2 |
| Chromosomal location | 11:58,203,207-58,204,142 (-) |
| Cluster | 11@58 |
| Synteny | CLIC#27 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1S1 | 91.67% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1S1P | 79% | 312 |
| Mouse | Or1s2 | 81% | 308 |
| Rat | Or1s2 | 77% | 307 |
| Cow | OR1S7 | 73% | 308 |
| Orang | OR1S1 | 91% | 312 |
| Horse | OR1S1 | 80% | 308 |
| Chimp | OR1S2P | 98% | 312 |
Sequence information
| Nucleotide sequence |
ATGCATCAAGAAAACCAAACCACCATCACTGAATTCATTCTCCTGGGACTCTCCAACCAG GCTGAACATCAAAACCTCCTCTTTGTGCTTTTCCTGAGTATGTATGTGGTCACTGTGGTT GGGAACGGGCTCATCATTGTGGCTATCAGCTTGGATATATACCTTCACACCCCCATGTAT CTCTTCCTTGCCTACCTATCCTTTGCTGATATTTCCTCCATTTCCAACTCAGTCCCCAAA ATGCTGGTGAATATTCAAACCAACAGCCAATCCATCTCTTATGAGAGCTGCATCACACAG ATGTACTTTTCTATTGTGTTTGTCGTCACTGACAATTTGCTTTTGGGGACCATGGCCTTC GACCACTTTGTGGCGATCTGCCACCCTCTGAACTATACAACTTTCATGCGGGCCAGGTTC GGCACTTTGCTCACAGTCATCTCGTGGTTCCTCAGTAATATTATTGCTCTTACACACACC CTTCTGCTCATTCAATTGCTCTTCTGTGACCACAACACTCTCCCACACTTCTTCTGTGAC TTGGCCCCTCTGCTCAAACTGTCCTGTTCAGATACAATGATCAATGAGCTTGTGTTGTTT ATTGTGGGTTTATCAGTTATCATCTTCCCCTTTGTACTCATCTTCTTCTCCTATGTCTGC ATCATCAGAGCTGTCCTGGGAGTATCATCCACACAGGGAAAGTGGAAAGCCTTCTCCACT TGTGGCTCTCACCTGACAATTGCATTACTGTTCTACGGAACCACTGTAGGCGTGTACTTT TTCCCCTCCTCCACTCACCCTGAGGACACTGATAAGATTGGTGCTGTCCTATTCACTGTG GTGACACCCATGATGAACCCCTTCATCTACAGCTTGAGGAATAAGGATATGAAAGGTGCC CTGAGAAAGCTCATCAATAGAAAAATTTCTTCCCTT |
| Conceptual translation |
MHQENQTTITEFILLGLSNQAEHQNLLFVLFLSMYVVTVVGNGLIIVAISLDIYLHTPMY LFLAYLSFADISSISNSVPKMLVNIQTNSQSISYESCITQMYFSIVFVVTDNLLLGTMAF DHFVAICHPLNYTTFMRARFGTLLTVISWFLSNIIALTHTLLLIQLLFCDHNTLPHFFCD LAPLLKLSCSDTMINELVLFIVGLSVIIFPFVLIFFSYVCIIRAVLGVSSTQGKWKAFST CGSHLTIALLFYGTTVGVYFFPSSTHPEDTDKIGAVLFTVVTPMMNPFIYSLRNKDMKGA LRKLINRKISSL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | A/G | I/T | 1000GP (YRI) |
| 11 | 100 | -100 | SYN | G/A | F/F | 1000GP (YRI, YRI) |
| 11 | 57,970,980 | 57,970,980 | NS | A/G | V/A | rs11229277 (DbSNP) |
| 11 | 57,970,980 | 57,970,981 | mnp | AC/GT | rs34249289 (DbSNP) | |
| 11 | 57,970,981 | 57,970,981 | NS | C/T | V/I | rs11229278 (DbSNP) |
| 11 | 57,971,195 | 57,971,195 | SYN | A/G | F/F | rs11229279 (DbSNP) |
| 11 | 57,971,201 | 57,971,201 | SYN | A/G | A/A | rs11229280 (DbSNP) |
| 11 | 57,971,478 | 57,971,478 | NS | A/G | I/T | rs11229281 (DbSNP) |
| 11 | 58,203,508 | 58,203,508 | NS | A/G | V/A | 1000GP (CEU) |
| 11 | 58,203,509 | 58,203,509 | NS | C/T | V/I | 1000GP (CEU) |
| 11 | 58,203,723 | 58,203,723 | SYN | G/A | F/F | 1000GP (CEU, CHBJPT) |
| 11 | 58,203,729 | 58,203,729 | SYN | G/A | A/A | 1000GP (CEU, CHBJPT) |
| 11 | 58,204,006 | 58,204,006 | NS | A/G | I/T | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 238 (Hasin) | |||
| 11 | 57,968,679 | 57,971,714 | CopyNumber | #72 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T268I | S243F | V225A | V225I | F163L | I59T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | T | S | V | V | F | I | 90.55 | 0.967 |
| 2 | T | S | V | V | F | T | 4.53 | 0.967 |
| 3 | T | S | A | I | F | T | 2.53 | 0.967 |
| 4 | I | S | V | V | F | I | 1.00 | 0.967 |
| 5 | T | S | V | I | F | T | 0.61 | 0.967 |
| 6 | I | S | V | V | F | T | 0.31 | 0.967 |
| 7 | T | F | V | V | F | I | 0.23 | 0.830 |
| 8 | T | S | A | V | F | I | 0.08 | 0.967 |
| 9 | T | S | A | V | F | T | 0.08 | 0.967 |
| 10 | T | S | V | V | L | I | 0.08 | 0.967 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1S2.aApr07-unspliced | main_exon | 3UTR | chr11 | 58,203,204 | 58,203,207 | - |
| CDS | chr11 | 58,203,207 | 58,204,142 | - | ||
| 5UTR | chr11 | 58,204,142 | 58,204,181 | - | ||