OR2A25 Olfactory Receptor
| Gene Symbol | OR2A251 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.18 (functional) |
| Aliases | HsOR7.6.11 |
| External Ids | HGNC: 19562 GeneBank: NM_001004488 |
| Build #39 labels | OR2A25P, OR2A27 |
| Chromosomal location | 7:144,074,220-144,075,149 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2A4 | 79.55% | 308 |
| OR2A7 | 80.19% | 308 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2A7 | 81% | 308 |
| Mouse | Or2a25 | 82% | 310 |
| Rat | Or2a25 | 82% | 310 |
| Cow | OR2A7 | 78% | 304 |
| Cow | OR2A7BP | 80% | 291 |
| Orang | OR2A7P | 80% | 308 |
| Horse | OR2A7 | 80% | 308 |
| Chimp | OR2A42 | 74% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136829 |
Sequence information
| Nucleotide sequence |
ATGGGGGGAAATCAGACTTCCATCACAGAGTTCCTCCTACTGGGATTTCCCATTGGCCCA AGGATTCAGATGCTCCTCTTTGGGCTCTTCTCCCTGTTCTACATCTTCATTCTGTTGGGG AACGGGACAATCCTGGGGCTCATCTCACTGGACTCCAGACTCCACACCCCCATGTACTTC TTCCTCTCACACCTGGCGGTCGTCGACATCGCCTGTGCTTGCAGCACGGTGCCCCAGATG CTGGTGAACCTCCTGCATCCAGCCAAGCCCATCTCCTTTGCTGGCTGCATGACCCAGATG TTTCTGTTTTTGAGTTTTGCACATACAGAATGTCTCCTCCTGGTGGTGATGTCCTATGAT CGGTACGTGGCCATCTGCCACCCTCTCCGATATTCTACCATCATGACCTGGAAAGTCTGC ATCACTTTGGCATTGACTTCCTGGATTTTAGGAGTCTTATTGGCCCTTGTCCATCTAGTG TTACTGCTACCACTGTCCTTCTGTGGACCCCAGAAACTTAATCACTTTTTCTGTGAAATT ATGGCTGTTCTCAAACTTGCCTGTGCGGATACCCACATTAATGAGGTAATGGTTTTGGCA GGGGCAGTGTCTGTGCTGGTGGGAGCCTTCTTTTCCACTGTAATATCTTATGTTCATATT CTATGTGCCATTCTAAAGATCCAGTCAGGAGAGGGGTGCCAGAAAGCCTTCTCCATCTGC TCCTCCCACCTCTGTGTGGTTGGACTCTTTTATGGCACAGCCATCATCATGTATGTTGAG CCCCAGTATGAGAGCCCCAAGGAGCAGAAGAAATATCTCCTGCTGTTTCACAGCCTCTTC AATCCCATGCTTAATCCCCTAATTTATAGTCTTAGGAACAAGGAAGTCCAAGGTACTCTA AAGAGGATGCTTGAAAAGAAGAGAACTTCA |
| Conceptual translation |
MGGNQTSITEFLLLGFPIGPRIQMLLFGLFSLFYIFILLGNGTILGLISLDSRLHTPMYF FLSHLAVVDIACACSTVPQMLVNLLHPAKPISFAGCMTQMFLFLSFAHTECLLLVVMSYD RYVAICHPLRYSTIMTWKVCITLALTSWILGVLLALVHLVLLLPLSFCGPQKLNHFFCEI MAVLKLACADTHINEVMVLAGAVSVLVGAFFSTVISYVHILCAILKIQSGEGCQKAFSIC SSHLCVVGLFYGTAIIMYVEPQYESPKEQKKYLLLFHSLFNPMLNPLIYSLRNKEVQGTL KRMLEKKRTS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,771,536 | 143,771,536 | NS | A/G | N/S | rs6951485 (DbSNP) |
| 7 | 143,771,937 | 143,771,937 | NS | C/G | P/A | rs2961135 (DbSNP) |
| 7 | 143,771,557 | 143,771,557 | NS | C/T | A/V | rs61731397 (DbSNP) |
| 7 | 143,772,218 | 143,772,218 | SYN | A/G | R/R | rs61729541 (DbSNP) |
| 7 | 143,771,408 | 143,771,408 | SYN | C/G | L/L | rs59319753 (DbSNP) |
| 7 | 144,074,315 | 144,074,315 | SYN | G/C | L/L | 1000GP (CEU, CHBJPT) |
| 7 | 144,074,443 | 144,074,443 | NS | G/A | S/N | 1000GP (CEU, CHBJPT) |
| 7 | 144,074,844 | 144,074,844 | NS | G/C | A/P | 1000GP (CEU, CHBJPT) |
| 7 | 100 | -100 | SYN | G/C | L/L | 1000GP (YRI, YRI) |
| 7 | 100 | -100 | NS | G/A | S/N | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,742,520 | 143,847,474 | CopyNumber | Variation_4570 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G2A | S75N | V82A | A209P | G298A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|
| 1 | G | N | V | P | G | 41.01 | 0.206 |
| 2 | G | S | V | A | G | 35.18 | 0.206 |
| 3 | G | N | A | P | G | 13.36 | 0.206 |
| 4 | G | N | V | A | G | 6.14 | 0.206 |
| 5 | G | S | V | P | G | 3.53 | 0.206 |
| 6 | G | N | A | A | G | 0.31 | 0.206 |
| 7 | G | N | V | P | A | 0.23 | 0.206 |
| 8 | G | S | A | A | G | 0.08 | 0.206 |
| 9 | G | N | V | A | A | 0.08 | 0.206 |
| 10 | A | N | V | P | G | 0.08 | 0.206 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2A25.aApr07-unspliced | main_exon | CDS | chr7 | 144,074,220 | 144,075,149 | + |
| 3UTR | chr7 | 144,075,149 | 144,075,152 | + | ||