OR2F1 Olfactory Receptor
| Gene Symbol | OR2F11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | F |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR7-139, OR7-140, OR14-60, OR7-7, OLF3, HsOR7.6.7, ORL166 |
| External Ids | HGNC: 8246 GeneBank: AF399594, BK004215, HSU56421, NM_012369, U86228, U86279, U86280 ORDB: ORL166 |
| Build #39 labels | OR2F1, OR2F3 |
| Chromosomal location | 7:143,959,971-143,960,921 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks | Segregating Pseudo Gene, a polymorphism in a highly conserved amino-acid (rs2072164) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2F2 | 90.22% | 317 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2F2 | 87% | 317 |
| Dog | OR2F1D | 87% | 317 |
| Dog | OR2F1C | 85% | 317 |
| Mouse | Or2f1 | 87% | 317 |
| Mouse | Or2f1b | 85% | 317 |
| Mouse | Or2f2 | 85% | 317 |
| Rat | Or2f2 | 85% | 317 |
| Rat | Or2f1b | 84% | 317 |
| Cow | OR2F2 | 86% | 317 |
| Cow | OR2F2B | 86% | 317 |
| Cow | OR2F1D | 85% | 317 |
| Orang | OR2F1E | 91% | 317 |
| Orang | OR2F2P | 89% | 317 |
| Horse | OR2F1F | 84% | 317 |
| Horse | OR2F1H | 83% | 317 |
| Horse | OR2F1G | 85% | 283 |
| Chimp | OR2F1D | 93% | 316 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC104975 |
| GNF Atlas2 | 208525_s_at |
| GNF Atlas2 | 208526_at |
Sequence information
| Nucleotide sequence |
ATGGGAACAGATAACCAGACTTGGGTGAGTGAATTTATTCTCCTCGGCCTGTCCAGTGAC TGGGACACTCGGGTCTCCCTGTTTGTCCTGTTCTTGGTCATGTATGTGGTGACCGTGCTG GGGAACTGTCTCATTGTCCTTCTGATCAGACTGGACAGCCGACTCCACACTCCCATGTAT TTCTTTCTCACCAACCTCTCCCTTGTCGATGTCTCCTATGCCACAAGTGTAGTCCCTCAG CTGCTGGCACATTTTCTTGCAGAACATAAAGCCATCCCATTCCAGAGCTGTGCAGCCCAG TTATTTTTCTCCCTGGCCTTGGGTGGGATTGAGTTTGTTCTCCTGGCGGTGATGGCCTAT GACCGCTATGTGGCTGTGTGTGATGCCCTGCGATACTCGGCCATCATGCATGGAGGGCTG TGTGCTAGGTTGGCCATCACATCCTGGGTCAGTGGCTTCATCAGCTCTCCTGTGCAGACT GCTATCACCTTTCAGCTGCCCATGTGCAGAAACAAGTTTATTGATCACATATCCTGTGAA CTCCTAGCTGTGGTCAGGCTGGCTTGTGTGGACACCTCCTCCAATGAGGTCACCATCATG GTGTCTAGCATTGTTCTTCTGATGACACCCTTCTGCCTGGTTCTTTTGTCCTACATCCAG ATCATCTCCACCATCCTAAAGATCCAGTCCAGAGAAGGAAGAAAGAAAGCTTTCCACACG TGTGCCTCTCACCTCACAGTGGTTGCCCTGTGCTATGGTGTGGCCATTTTCACTTACATC CAGCCCCACTCCAGTCCCTCTGTCCTTCAGGAGAAGTTGTTCTCTGTCTTTTATGCCATT TTAACACCAATGCTGAACCCCATGATTTACAGCCTAAGGAATAAAGAGGTGAAGGGGGCC TGGCAGAAACTATTATGGAAATTCTCTGGGTTAACATCAAAGCTGGCAACT |
| Conceptual translation |
MGTDNQTWVSEFILLGLSSDWDTRVSLFVLFLVMYVVTVLGNCLIVLLIRLDSRLHTPMY FFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAY DRYVAVCDALRYSAIMHGGLCARLAITSWVSGFISSPVQTAITFQLPMCRNKFIDHISCE LLAVVRLACVDTSSNEVTIMVSSIVLLMTPFCLVLLSYIQIISTILKIQSREGRKKAFHT CASHLTVVALCYGVAIFTYIQPHSSPSVLQEKLFSVFYAILTPMLNPMIYSLRNKEVKGA WQKLLWKFSGLTSKLAT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,657,473 | 143,657,473 | NS | A/G | H/R | rs2072165 (DbSNP) |
| 7 | 143,657,232 | 143,657,232 | NS | A/G | T/A | rs73464587 (DbSNP) |
| 7 | 143,657,573 | 143,657,573 | NS | A/T | R/S | rs61731396 (DbSNP) |
| 7 | 143,657,782 | 143,657,782 | NS | C/T | T/M | rs73464588 (DbSNP) |
| 7 | 143,657,427 | 143,657,427 | NS | C/T | R/C | rs2072164 (DbSNP) |
| 7 | 143,657,801 | 143,657,801 | SYN | A/G | T/T | rs2072166 (DbSNP) |
| 7 | 143,960,334 | 143,960,334 | NS | C/T | R/C | 1000GP (CEU, CHBJPT) |
| 7 | 143,960,708 | 143,960,708 | SYN | A/G | T/T | 1000GP (CEU, CHBJPT) |
| 7 | 100 | -100 | NS | C/T | R/C | 1000GP (YRI, YRI) |
| 7 | 100 | -100 | SYN | A/G | T/T | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,615,165 | 143,744,519 | CopyNumber | Variation_0110 (DGV) |
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,208,034 | 143,736,035 | CopyNumber | Variation_5247 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R122C | H137R | I162V | % Freq | CORP | |
|---|---|---|---|---|---|
| 1 | R | H | I | 77.80 | 0.612 |
| 2 | R | R | I | 10.98 | 0.612 |
| 3 | C | R | I | 9.83 | 0.966 |
| 4 | C | H | I | 1.08 | 0.966 |
| 5 | R | H | V | 0.31 | 0.612 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2F1.aApr07-unspliced | main_exon | 5UTR | chr7 | 143,959,641 | 143,959,971 | + |
| CDS | chr7 | 143,959,971 | 143,960,921 | + | ||
| 3UTR | chr7 | 143,960,921 | 143,961,015 | + | ||