OR2M4 Olfactory Receptor
| Gene Symbol | OR2M41 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | M |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | OR1-55, HSHTPCRX18, OST710, HsOR1.5.32, ORL203 |
| External Ids | HGNC: 8270 GeneBank: AB065953, AF399617, BK004483, HSHTPRX18, HSTPCR100, NM_017504 ORDB: ORL203 |
| Build #39 labels | OR2M4 |
| Chromosomal location | 1:248,238,929-248,239,861 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2M2 | 74.11% | 309 |
| OR2M3 | 74.43% | 309 |
| OR2M5 | 74.43% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2M10P | 77% | 307 |
| Mouse | Or2m12 | 70% | 307 |
| Rat | Or2m12 | 70% | 308 |
| Cow | OR2M10 | 77% | 309 |
| Orang | OR2M4P | 96% | 311 |
| Horse | OR2M24 | 76% | 309 |
| Chimp | OR2M10 | 75% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463960 |
| GNF Atlas2 | gnf1h05779_at |
Sequence information
| Nucleotide sequence |
ATGGTGTGGGAAAACCAGACCTTCAACTCCATCTTCATCCTGCTGGGAATCTTCAATCAC AGTCCCACCCACACCTTCCTTTTTTCTCTGGTCCTGGGCATCTTCTCACTGGCATTGATG GAAAATATTTCCATGGTTCTCCTCATCTACATAGAGAAACAGCTCCACACCCCCATGTAC TTCCTCCTCAGTCAACTGTCCCTTATGGACCTCATGCTCATCTGCACCACTCTACCCAAG ATGATCTTCAGCTACTTGTCTGGGAAGAAATCTATCTCTCTGGCAGGTTGTGGAACTCAG ATATTCTTCTATGTGTCCCTGCTTGGAGCTGAATGTTTCTTGTTGGCTGTCATGGCTTAT GACCGCTATGTGGCTATATGTCACCCTCTTCAGTACACCATCCTCATGAATCCGAAACTC TGTGTCTTCATGACTGTTGCTTCCTGGACCTTGGGGTCTCTTGATGGGATCATAGTGCTT GCAGCTGTCCTGTCATTTTCTTACTGCAGCTCTCTGGAAATTCATCACTTTTTCTGTGAT GTTGCTGCCCTTTTACCTCTATCCTGCACAGAAACATCTGCATTTGAAAGACTACTTGTC ATTTGTTGTGTGGTAATGCTAATCTTTCCAGTTTCAGTTATCATACTTTCCTATTCCCAT GTCCTTCGAGCCGTCATCCACATGGGCTCTGGGGAAAGTCGTCGCAAGGCCTTCACTACC TGCTCCTCCCACCTGTCTGTGGTCGGACTCTACTACGGTGCTGCTATGTTCATGTACATG AGACCAGCTTCTAAACATACGCCAGACCAGGACAAGATGGTGTCGGCCTTCTACACTATT CTCACCCCTATGCTGAACCCTCTCATTTATAGCCTCCGCAACAAAGAAGTGTTCAGGGCA CTACAGAAGGTACTGAAGAAAAGAAAGTTAATA |
| Conceptual translation |
MVWENQTFNSIFILLGIFNHSPTHTFLFSLVLGIFSLALMENISMVLLIYIEKQLHTPMY FLLSQLSLMDLMLICTTLPKMIFSYLSGKKSISLAGCGTQIFFYVSLLGAECFLLAVMAY DRYVAICHPLQYTILMNPKLCVFMTVASWTLGSLDGIIVLAAVLSFSYCSSLEIHHFFCD VAALLPLSCTETSAFERLLVICCVVMLIFPVSVIILSYSHVLRAVIHMGSGESRRKAFTT CSSHLSVVGLYYGAAMFMYMRPASKHTPDQDKMVSAFYTILTPMLNPLIYSLRNKEVFRA LQKVLKKRKLI Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | SYN | C/T | H/H | 1000GP (YRI) |
| 1 | 248,239,080 | 248,239,080 | NS | T/A | I/K | 1000GP (CEU) |
| 1 | 248,239,456 | 248,239,456 | SYN | C/T | H/H | 1000GP (CEU, CHBJPT) |
| 1 | 248,402,594 | 248,402,594 | NS | C/T | R/C | rs61743231 (DbSNP) |
| 1 | 248,402,758 | 248,402,758 | SYN | C/T | H/H | rs6666148 (DbSNP) |
| 1 | 248,402,989 | 248,402,989 | SYN | G/T | G/G | rs11586547 (DbSNP) |
| 1 | 248,403,015 | 248,403,015 | NS | A/C | Q/P | rs41303133 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 62 (Hasin) | |||
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,242,528 | 248,817,382 | CopyNumber | Variation_8935 (DGV) |
| 1 | 248,319,780 | 248,490,372 | CopyNumber | Variation_31702 (DGV) |
| 1 | 248,402,131 | 248,405,163 | CopyNumber | #31 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I51K | P262Q | S275L | % Freq | CORP | |
|---|---|---|---|---|---|
| 1 | I | P | S | 99.02 | 0.110 |
| 2 | I | Q | S | 0.55 | 0.110 |
| 3 | K | P | S | 0.22 | 0.110 |
| 4 | I | P | L | 0.22 | 0.110 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2M4.aApr07-unspliced | main_exon | CDS | chr1 | 248,238,929 | 248,239,861 | + |
| 3UTR | chr1 | 248,239,861 | 248,239,864 | + | ||