OR3A1 Olfactory Receptor
| Gene Symbol | OR3A11 (View this gene in GeneCards) |
| Family | 3 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR17-15, OR17-40, OLFRA03, hg138, HsOR17.1.11, ORL520, ORL594 |
| External Ids | HGNC: 8282 GeneBank: AF087924, BC069414, BK004238, HSOR1740, HSU04683, NM_002550 ORDB: ORL520, ORL594 |
| Build #39 labels | OR3A1 |
| Chromosomal location | 17:3,291,638-3,292,582 (-) |
| Cluster | 17@3b |
| Synteny | CLIC#39 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs863362 (AA change=W/* ) and rs703903 (highly conserved AA) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR3A2 | 81.53% | 314 |
| OR3A3 | 77.71% | 314 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR3A1H | 84% | 315 |
| Mouse | Or3a1 | 85% | 315 |
| Mouse | Or3a1c | 83% | 315 |
| Rat | Or3a1 | 85% | 315 |
| Rat | Or3a1e | 84% | 315 |
| Cow | OR3A1D | 84% | 315 |
| Cow | OR3A2 | 81% | 315 |
| Orang | OR3A1P | 92% | 315 |
| Horse | OR3A1I | 81% | 315 |
| Horse | OR3A2D | 81% | 314 |
| Chimp | OR3A2 | 82% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC096190 |
| GNF Atlas2 | 221353_at |
Sequence information
| Nucleotide sequence |
ATGCAGCCAGAATCTGGGGCCAATGGAACAGTCATTGCTGAGTTCATCCTGCTGGGCTTG CTGGAGGCGCCAGGGCTGCAGCCAGTTGTCTTTGTGCTCTTCCTCTTTGCCTACCTGGTC ACGGTCAGGGGCAACCTCAGCATCCTGGCAGCTGTCTTGGTGGAGCCCAAACTCCACACC CCCATGTACTTCTTCCTGGGGAACCTATCAGTGCTGGATGTTGGGTGCATCAGCGTCACT GTTCCATCAATGTTGAGTCGTCTCCTGTCCCGCAAGCGTGCAGTTCCCTGTGGGGCCTGC CTTACCCAGCTCTTCTTCTTCCATCTGTTCGTTGGAGTGGACTGCTTCCTGCTGACCGCC ATGGCCTATGACCGATTCCTGGCCATCTGCCGGCCCCTCACCTACAGCACCCGCATGAGT CAGACAGTCCAGAGGATGTTGGTGGCTGCGTCCTGGGCTTGTGCTTTCACCAACGCACTG ACCCACACTGTGGCCATGTCCACGCTCAACTTCTGTGGCCCCAATGTGATCAATCACTTC TACTGTGACCTCCCACAGCTCTTCCAGCTCTCCTGCTCCAGCACCCAACTCAATGAGCTG CTGCTTTTTGCTGTGGGTTTTATAATGGCAGGTACCCCCATGGCTCTCATTGTCATCTCC TATATCCACGTGGCAGCTGCAGTCCTGCGAATTCGCTCTGTAGAGGGCAGGAAGAAAGCC TTCTCCACATGTGGCTCCCACCTCACTGTGGTTGCCATATTCTATGGTTCAGGTATCTTT AACTATATGCGACTGGGTTCAACCAAGCTTTCAGACAAGGATAAAGCTGTTGGAATTTTC AACACTGTCATCAATCCCATGCTGAACCCAATCATCTACAGCTTCAGAAACCCTGATGTG CAGAGTGCCATCTGGAGGATGCTCACAGGGAGGCGGTCACTGGCT |
| Conceptual translation |
MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRGNLSILAAVLVEPKLHT PMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVPCGACLTQLFFFHLFVGVDCFLLTA MAYDRFLAICRPLTYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTLNFCGPNVINHF YCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPMALIVISYIHVAAAVLRIRSVEGRKKA FSTCGSHLTVVAIFYGSGIFNYMRLGSTKLSDKDKAVGIFNTVINPMLNPIIYSFRNPDV QSAIWRMLTGRRSLA Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 17 | 100 | -100 | nonsense SNP | T/A | K/* | 1000GP (YRI) |
| 17 | 100 | -100 | NS | C/T | G/D | 1000GP (YRI, YRI, YRI) |
| 17 | 3,195,245 | 3,195,245 | NS | T/C | D/G | rs61734041 (DbSNP) |
| 17 | 3,195,336 | 3,195,336 | NS | G/A | H/Y | rs61734042 (DbSNP) |
| 17 | 3,195,353 | 3,195,353 | NS | T/C | N/S | rs61734043 (DbSNP) |
| 17 | 3,195,381 | 3,195,381 | NS | T/C | M/V | rs61734045 (DbSNP) |
| 17 | 3,195,501 | 3,195,501 | NS | G/A | L/F | rs56379678 (DbSNP) |
| 17 | 3,195,503 | 3,195,503 | NS | C/T | R/Q | rs703903 (DbSNP) |
| 17 | 3,195,599 | 3,195,599 | NS | T/C | H/R | rs61736316 (DbSNP) |
| 17 | 3,195,603 | 3,195,603 | nonsense SNP | A/T | */K | rs7218125 (DbSNP) |
| 17 | 3,195,645 | 3,195,645 | NS | C/T | G/S | rs16952828 (DbSNP) |
| 17 | 3,292,209 | 3,292,209 | NS | C/T | R/Q | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 43 (Hasin) | |||
| 17 | 3,192,932 | 3,195,976 | CopyNumber | #98 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| W305R | R264* | F254L | Y221C | G211D | Y181H | N175S | M166V | R125Q | K92* | S78G | F34I | A23S | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | W | R | F | Y | G | Y | N | M | Q | K | S | F | A | 56.61 | 0.796 |
| 2 | W | R | F | Y | G | Y | N | M | R | K | S | F | A | 39.32 | 0.179 |
| 3 | W | R | F | Y | G | Y | N | M | R | * | S | F | A | 1.08 | 1.200 |
| 4 | W | R | F | Y | G | Y | N | V | R | K | S | F | A | 0.61 | 0.179 |
| 5 | W | R | F | Y | G | H | S | M | R | * | S | F | A | 0.54 | 1.200 |
| 6 | W | R | F | Y | D | Y | N | M | R | K | S | F | A | 0.46 | 0.179 |
| 7 | W | R | F | Y | G | Y | N | M | R | K | G | F | A | 0.46 | 0.179 |
| 8 | W | R | L | Y | G | Y | N | M | R | K | S | F | A | 0.31 | 0.232 |
| 9 | W | R | F | Y | G | Y | N | M | Q | K | S | I | A | 0.23 | 0.796 |
| 10 | W | R | F | Y | G | Y | N | M | Q | K | S | F | S | 0.15 | 0.796 |
| 11 | W | * | F | Y | G | Y | N | M | R | K | S | F | A | 0.08 | 1.200 |
| 12 | R | R | F | Y | G | Y | N | M | R | K | S | F | A | 0.08 | 0.179 |
| 13 | W | R | F | C | G | Y | N | M | R | K | S | F | A | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR3A1.aApr07-unspliced | main_exon | 3UTR | chr17 | 3,291,635 | 3,291,638 | - |
| CDS | chr17 | 3,291,638 | 3,292,582 | - | ||