OR4B1 Olfactory Receptor
| Gene Symbol | OR4B11 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OST208, OR11-106, HsOR11.8.1, ORL3379 |
| External Ids | HGNC: 8290 GeneBank: AB065848, AF399579, BK004387, NM_001005470 ORDB: ORL3379 |
| Build #39 labels | OR4B1 |
| Chromosomal location | 11:48,216,810-48,217,736 (+) |
| Cluster | 11@48 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4B2P | 71.2% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4B1E | 85% | 308 |
| Mouse | Or4b1 | 83% | 303 |
| Mouse | Or4b1b | 80% | 309 |
| Mouse | Or4b1c | 82% | 299 |
| Mouse | Or4b1d | 81% | 304 |
| Rat | Or4b1c | 83% | 305 |
| Rat | Or4b1 | 83% | 304 |
| Rat | Or4b1b-ps | 82% | 305 |
| Cow | OR4B1H | 84% | 309 |
| Orang | OR4B2P | 70% | 309 |
| Horse | OR4B1I | 82% | 309 |
| Chimp | OR4B2P | 71% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h10913_at |
Sequence information
| Nucleotide sequence |
ATGGCCAGTACAAGTAATGTGACTGAGTTGATTTTCACTGGCCTTTTCCAGGATCCAGCT GTGCAGAGTGTATGCTTTGTGGTGTTTCTCCCCGTGTACCTTGCCACGGTGGTGGGCAAT GGCCTCATCGTTCTGACGGTCAGTATCAGCAAGAGTCTGGATTCTCCCATGTACTTCTTC CTTAGCTGCCTGTCCTTGGTGGAGATCAGTTATTCCTCCACTATCGCCCCTAAATTCATC ATAGACTTACTTGCCAAGATTAAAACCATCTCTCTGGAAGGCTGTCTGACTCAGATATTC TTCTTCCACTTCTTTGGGGTTGCTGAGATCCTTTTGATTGTGGTGATGGCCTATGATTGC TACGTGGCCATTTGCAAGCCTCTTCATTATATGAACATTATCAGTCGTCAACTGTGTCAC CTTCTGGTGGCTGGTTCCTGGCTGGGGGGCTTTTGTCACTCCATAATTCAGATTCTCGTT ATCATCCAATTGCCCTTCTGTGGTCCCAATGTGATTGACCACTATTTCTGTGACCTCCAG CCTTTATTCAAGCTTGCCTGCACTGACACCTTCATGGAGGGGGTTATTGTGTTGGCCAAC AGTGGATTATTCTCTGTCTTCTCCTTCCTCATCTTGGTGTCCTCTTATATTGTCATTCTG GTCAACTTGAGGAACCATTCTGCAGAGGGGAGGCACAAAGCCCTCTCCACCTGTGCTTCT CACATCACAGTGGTCATCTTGTTTTTTGGACCTGCTATCTTCCTCTACATGCGACCTTCT TCCACTTTCACTGAAGATAAACTTGTGGCTGTATTCTACACGGTCATCACCCCCATGCTG AACCCCATCATTTACACACTCAGGAATGCAGAGGTGAAAATCGCCATAAGAAGATTGTGG AGCAAAAAGGAGAATCCAGGGAGGGAG |
| Conceptual translation |
MASTSNVTELIFTGLFQDPAVQSVCFVVFLPVYLATVVGNGLIVLTVSISKSLDSPMYFF LSCLSLVEISYSSTIAPKFIIDLLAKIKTISLEGCLTQIFFFHFFGVAEILLIVVMAYDC YVAICKPLHYMNIISRQLCHLLVAGSWLGGFCHSIIQILVIIQLPFCGPNVIDHYFCDLQ PLFKLACTDTFMEGVIVLANSGLFSVFSFLILVSSYIVILVNLRNHSAEGRHKALSTCAS HITVVILFFGPAIFLYMRPSSTFTEDKLVAVFYTVITPMLNPIIYTLRNAEVKIAIRRLW SKKENPGRE Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 48,239,071 | 48,239,071 | NS | A/C | N/T | rs12292056 (DbSNP) |
| 11 | 48,239,182 | 48,239,182 | NS | A/C/T | K/T | rs7130086 (DbSNP) |
| 11 | 48,238,998 | 48,238,998 | NS | A/G | M/V | rs61731415 (DbSNP) |
| 11 | 48,239,016 | 48,239,016 | NS | A/G | I/V | rs61731414 (DbSNP) |
| 11 | 48,238,549 | 48,238,549 | NS | A/G | Y/C | rs11606506 (DbSNP) |
| 11 | 48,239,215 | 48,239,215 | NS | A/G | Y/C | rs61731410 (DbSNP) |
| 11 | 48,238,500 | 48,238,500 | NS | A/G | I/V | rs61731419 (DbSNP) |
| 11 | 48,238,496 | 48,238,496 | SYN | C/G | L/L | rs61731420 (DbSNP) |
| 11 | 48,238,773 | 48,238,773 | SYN | C/T | L/L | rs61731416 (DbSNP) |
| 11 | 48,238,880 | 48,238,880 | SYN | C/T | D/D | rs10838833 (DbSNP) |
| 11 | 48,238,724 | 48,238,724 | SYN | C/T | Y/Y | rs61731418 (DbSNP) |
| 11 | 48,238,421 | 48,238,421 | SYN | G/T | A/A | rs10769329 (DbSNP) |
| 11 | 48,216,869 | 48,216,869 | SYN | T/G | A/A | 1000GP (CEU) |
| 11 | 48,217,328 | 48,217,328 | SYN | C/T | D/D | 1000GP (CEU, CHBJPT) |
| 11 | 48,217,630 | 48,217,630 | NS | C/A | T/K | 1000GP (CEU, CHBJPT) |
| 11 | 48,217,519 | 48,217,519 | NS | C/A | T/N | 1000GP (CEU, CHBJPT) |
| 11 | 48,216,997 | 48,216,997 | NS | G/A | C/Y | 1000GP (CEU, CHBJPT) |
| 11 | 48,216,870 | 48,216,870 | NS | G/A | V/M | 1000GP (CHBJPT) |
| 11 | 100 | -100 | SYN | T/G | A/A | 1000GP (YRI, YRI) |
| 11 | 100 | -100 | NS | G/A | V/I | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 48,238,262 | 48,241,288 | CopyNumber | #138 (Waszak) |
| 11 | 48,238,610 | 48,238,837 | Del(-17) | #19(modil) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V47I | C63Y | V213M | I219V | T237N | T274K | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | V | C | V | I | T | T | 65.90 | 0.719 |
| 2 | V | Y | V | I | T | K | 19.97 | 0.719 |
| 3 | V | C | V | I | N | T | 11.06 | 0.905 |
| 4 | V | Y | V | I | T | T | 1.23 | 0.719 |
| 5 | I | C | V | V | T | T | 1.15 | 0.719 |
| 6 | V | C | M | I | N | T | 0.46 | 0.905 |
| 7 | V | C | V | I | T | K | 0.23 | 0.719 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4B1.aApr07-unspliced | main_exon | CDS | chr11 | 48,216,810 | 48,217,736 | + |
| 3UTR | chr11 | 48,217,736 | 48,217,739 | + | ||