OR4C3 Olfactory Receptor
| Gene Symbol | OR4C31 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OR11-98, HsOR11.8.6, ORL3738 |
| External Ids | HGNC: 14697 GeneBank: AB065567, BK004349, NM_001004702 ORDB: ORL3738 |
| Build #39 labels | OR4C3 |
| Chromosomal location | 11:48,325,022-48,325,927 (+) |
| Cluster | 11@48 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4C49P | 92.38% | 302 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4C26 | 86% | 301 |
| Mouse | Or4c3 | 85% | 301 |
| Rat | Or4c3 | 84% | 301 |
| Cow | OR4C3B | 78% | 300 |
| Orang | OR4C9P | 63% | 295 |
| Horse | OR4C3C | 79% | 289 |
| Chimp | OR4C49 | 93% | 302 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136854 |
Sequence information
| Nucleotide sequence |
ATGGACATACCACAAAATATCACAGAATTTTTCATGCTGGGGCTCTCACAGAACTCAGAG GTACAGAGAGTTCTCTTTGTGGTCTTTTTGCTGATCTATGTGGTCACGGTTTGTGGCAAC ATGCTCATTGTGGTCACTATCACCTCCAGCCCCACGCTGGCTTCCCCTGTGTATTTTTTC CTGGCCAACCTATCCTTTATTGACACCTTTTATTCTTCTTCTATGGCTCCTAAACTCATT GCTGACTCATTGTATGAGGGGAGAACCATCTCTTATGAGTGCTGCATGGCTCAGCTCTTT GGAGCTCATTTTTTGGGAGGTGTTGAGATCATTCTGCTCACAGTGATGGCTTATGACCGC TATGTGGCCATCTGTAAGCCCCTGCACAATACTACCATCATGACCAGGCATCTCTGTGCC ATGCTTGTAGGGGTGGCTTGGCTTGGGGGCTTCCTGCATTCATTGGTTCAGCTCCTCCTG GTCCTTTGGTTGCCCTTCTGTGGGCCCAATGTGATCAATCACTTTGCCTGTGACTTGTAC CCTTTGCTGGAAGTTGCCTGCACCAATACGTATGTCATTGGTCTGCTGGTGGTTGCCAAC AGTGGTTTAATCTGCCTGTTGAACTTCCTCATGCTGGCTGCCTCCTACATTGTCATCCTG TACTCCTTGAGGTCCCACAGTGCAGATGGGAGATGCAAAGCCCTCTCCACCTGTGGAGCC CACTTCATTGTTGTTGCCTTGTTCTTTGTGCCCTGTATATTTACTTATGTGCATCCATTT TCTACTTTACCTATAGACAAAAATATGGCATTATTTTATGGTATTCTGACACCTATGTTG AATCCACTCATTTATACCCTGAGAAATGAAGAGGTAAAAAATGCCATGAGAAAGCTCTTT ACATGG |
| Conceptual translation |
MDIPQNITEFFMLGLSQNSEVQRVLFVVFLLIYVVTVCGNMLIVVTITSSPTLASPVYFF LANLSFIDTFYSSSMAPKLIADSLYEGRTISYECCMAQLFGAHFLGGVEIILLTVMAYDR YVAICKPLHNTTIMTRHLCAMLVGVAWLGGFLHSLVQLLLVLWLPFCGPNVINHFACDLY PLLEVACTNTYVIGLLVVANSGLICLLNFLMLAASYIVILYSLRSHSADGRCKALSTCGA HFIVVALFFVPCIFTYVHPFSTLPIDKNMALFYGILTPMLNPLIYTLRNEEVKNAMRKLF TW Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 48,346,669 | 48,346,677 | In-Del(9) | -/GATCAGCAA | rs34634151 (DbSNP) | |
| 11 | 48,347,014 | 48,347,014 | nonsense SNP | A/G | */W | rs72473368 (DbSNP) |
| 11 | 48,346,579 | 48,346,579 | NS | A/C | E/D | rs72911452 (DbSNP) |
| 11 | 48,347,067 | 48,347,067 | NS | C/T | P/L | rs73464001 (DbSNP) |
| 11 | 48,347,223 | 48,347,223 | NS | C/T | T/I | rs61735142 (DbSNP) |
| 11 | 48,347,100 | 48,347,100 | NS | C/T | A/V | rs73465905 (DbSNP) |
| 11 | 48,347,267 | 48,347,267 | NS | C/T | R/C | rs73465910 (DbSNP) |
| 11 | 48,346,791 | 48,346,791 | NS | C/T | S/F | rs73463994 (DbSNP) |
| 11 | 48,346,946 | 48,346,946 | NS | C/T | R/C | rs61744624 (DbSNP) |
| 11 | 48,346,996 | 48,346,996 | NS | G/A | M/I | rs12794960 (DbSNP) |
| 11 | 48,347,306 | 48,347,306 | NS | G/T | V/F | rs73465911 (DbSNP) |
| 11 | 48,346,822 | 48,346,822 | SYN | A/C | S/S | rs73463997 (DbSNP) |
| 11 | 48,346,615 | 48,346,615 | SYN | A/G | G/G | rs73463988 (DbSNP) |
| 11 | 48,347,419 | 48,347,419 | SYN | A/G | P/P | rs73465913 (DbSNP) |
| 11 | 48,346,729 | 48,346,729 | SYN | C/G | T/T | rs73463990 (DbSNP) |
| 11 | 48,347,023 | 48,347,023 | SYN | C/T | G/G | rs67077733 (DbSNP) |
| 11 | 48,346,924 | 48,346,924 | SYN | C/T | A/A | rs72911454 (DbSNP) |
| 11 | 48,347,140 | 48,347,140 | SYN | C/T | N/N | rs10838874 (DbSNP) |
| 11 | 48,346,843 | 48,346,843 | SYN | C/T | I/I | rs73463998 (DbSNP) |
| 11 | 48,346,999 | 48,346,999 | SYN | G/T | L/L | rs72473367 (DbSNP) |
| 11 | 48,325,578 | 48,325,578 | NS | C/G | A/G | 1000GP (CEU) |
| 11 | 48,325,806 | 48,325,806 | NS | C/T | T/I | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,794 | 48,325,794 | NS | A/T | H/L | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,588 | 48,325,588 | SYN | T/C | N/N | 1000GP (CEU) |
| 11 | 48,325,811 | 48,325,811 | NS | C/T | P/S | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,129 | 48,325,129 | SYN | G/A | T/T | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,177 | 48,325,177 | SYN | G/C | T/T | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,052 | 48,325,052 | NS | T/G | F/V | 1000GP (CEU, CHBJPT) |
| 11 | 48,325,027 | 48,325,027 | NS | C/A | D/E | 1000GP (CHBJPT) |
| 11 | 48,325,036 | 48,325,036 | NS | A/C | Q/H | 1000GP (CHBJPT) |
| 11 | 48,325,063 | 48,325,063 | SYN | G/A | G/G | 1000GP (CHBJPT) |
| 11 | 48,325,790 | 48,325,790 | NS | G/A | V/M | 1000GP (CHBJPT) |
| 11 | 48,325,840 | 48,325,840 | SYN | T/C | Y/Y | 1000GP (CHBJPT) |
| 11 | 48,325,867 | 48,325,867 | SYN | A/G | P/P | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | C/A | D/E | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | G/G | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 48,303,671 | 48,863,606 | CopyNumber | Variation_3848 (DGV) |
| 11 | 48,346,202 | 48,972,502 | CopyNumber | Variation_9183 (DGV) |
| CopyNumber | 6 (Hasin) | |||
| 11 | 48,346,474 | 48,349,479 | CopyNumber | #175 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V284M | H285L | P291S | % Freq | CORP | |
|---|---|---|---|---|---|
| 1 | V | H | P | 43.01 | 1.000 |
| 2 | M | L | S | 27.11 | 1.000 |
| 3 | M | L | P | 14.98 | 1.000 |
| 4 | V | H | S | 14.90 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4C3.aApr07-unspliced | main_exon | 5UTR | chr11 | 48,324,941 | 48,325,022 | + |
| CDS | chr11 | 48,325,022 | 48,325,927 | + | ||
| 3UTR | chr11 | 48,325,927 | 48,325,930 | + | ||