OR4D2 Olfactory Receptor
| Gene Symbol | OR4D21 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | D |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | OR17-24, AC005962-B, HsOR17.2.2, ORL3745 |
| External Ids | HGNC: 8294 GeneBank: AB065912, AF399568, BK004224 ORDB: ORL3745 |
| Build #39 labels | OR4D2 |
| Chromosomal location | 17:58,169,656-58,170,576 (+) |
| Cluster | 17@56 |
| Synteny | CLIC#40 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4D1 | 79.87% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4D2C | 87% | 298 |
| Mouse | Or4d2b | 84% | 307 |
| Mouse | Or4d2 | 84% | 304 |
| Rat | Or4d2 | 84% | 304 |
| Rat | Or4d2b | 84% | 304 |
| Cow | OR4D2G | 84% | 307 |
| Cow | OR4D2F | 82% | 307 |
| Cow | OR4D2B | 82% | 303 |
| Orang | OR4D2P | 94% | 307 |
| Horse | OR4D2H | 85% | 307 |
| Chimp | OR4D2P | 98% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463963 |
| GNF Atlas2 | gnf1h07005_at |
Sequence information
| Nucleotide sequence |
ATGGAAACAGGGAACCTCACGTGGGTATCAGACTTTGTCTTCCTGGGGCTCTCGCAGACT CGGGAGCTCCAGCGTTTCCTGTTTCTAATGTTCCTGTTTGTCTACATCACCACTGTTATG GGAAACATCCTTATCATCATCACAGTGACCTCTGATTCCCAGCTCCACACACCCATGTAC TTTCTGCTCCGAAACCTGGCTGTCCTAGACCTCTGTTTCTCTTCAGTCACTGCTCCCAAA ATGCTAGTGGACCTCCTCTCTGAGAAGAAAACCATCTCTTACCAGGGCTGCATGGGTCAG ATCTTCTTCTTCCACTTTTTGGGAGGTGCCATGGTCTTCTTCCTCTCAGTGATGGCCTTT GACCGCCTCATTGCCATCTCCCGGCCCCTCCGCTATGTCACCGTCATGAACACTCAGCTC TGGGTGGGGCTGGTGGTAGCCACCTGGGTGGGAGGCTTTGTCCACTCTATTGTCCAGCTG GCTCTGATGCTCCCACTGCCCTTCTGTGGCCCCAACATTTTGGATAACTTCTACTGTGAT GTTCCCCAAGTACTGAGACTTGCCTGCACTGACACCTCACTGCTGGAGTTCCTCAAGATC TCCAACAGTGGGCTGCTGGATGTCGTCTGGTTCTTCCTCCTCCTGATGTCCTACTTATTC ATCCTGGTGATGCTGAGGTCACATCCAGGGGAGGCAAGAAGGAAGGCAGCTTCCACCTGC ACCACCCACATCATCGTGGTTTCCATGATCTTCGTTCCAAGCATTTACCTCTATGCCCGG CCCTTCACTCCATTCCCTATGGACAAGCTTGTGTCCATCGGCCACACAGTCATGACCCCC ATGCTCAACCCCATGATCTATACCCTGAGGAACCAGGACATGCAGGCAGCAGTGAGAAGA TTAGGGAGACACCGGCTGGTT |
| Conceptual translation |
METGNLTWVSDFVFLGLSQTRELQRFLFLMFLFVYITTVMGNILIIITVTSDSQLHTPMY FLLRNLAVLDLCFSSVTAPKMLVDLLSEKKTISYQGCMGQIFFFHFLGGAMVFFLSVMAF DRLIAISRPLRYVTVMNTQLWVGLVVATWVGGFVHSIVQLALMLPLPFCGPNILDNFYCD VPQVLRLACTDTSLLEFLKISNSGLLDVVWFFLLLMSYLFILVMLRSHPGEARRKAASTC TTHIIVVSMIFVPSIYLYARPFTPFPMDKLVSIGHTVMTPMLNPMIYTLRNQDMQAAVRR LGRHRLV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 17 | 100 | -100 | NS | G/A | R/Q | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 17 | 100 | -100 | SYN | A/G | V/V | 1000GP (YRI, YRI) |
| 17 | 56,247,078 | 56,247,078 | NS | A/G | Q/R | rs73323532 (DbSNP) |
| 17 | 56,247,101 | 56,247,101 | NS | A/C | I/L | rs60994383 (DbSNP) |
| 17 | 56,247,118 | 56,247,118 | SYN | C/G | V/V | rs35905234 (DbSNP) |
| 17 | 56,247,454 | 56,247,454 | SYN | A/G | V/V | rs9912728 (DbSNP) |
| 17 | 56,247,885 | 56,247,885 | NS | A/G | K/R | rs73993621 (DbSNP) |
| 17 | 58,169,716 | 58,169,716 | NS | C/T | R/W | 1000GP (CHBJPT) |
| 17 | 58,169,740 | 58,169,740 | NS | C/A | L/I | 1000GP (CEU, CHBJPT) |
| 17 | 58,169,945 | 58,169,945 | NS | G/C | C/S | 1000GP (CEU) |
| 17 | 58,170,093 | 58,170,093 | SYN | A/G | V/V | 1000GP (CEU) |
| 17 | 58,170,214 | 58,170,214 | NS | C/T | L/F | 1000GP (CEU) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 242 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R21W | R21Q | L29I | C97S | L187F | A236S | R260W | T263A | R290K | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R | R | L | C | L | A | R | T | R | 67.13 | 0.050 |
| 2 | R | R | I | C | L | A | R | T | R | 18.43 | 0.050 |
| 3 | R | R | L | S | F | A | R | T | R | 8.45 | 0.817 |
| 4 | R | R | I | C | L | A | R | T | K | 3.15 | 0.050 |
| 5 | R | Q | I | C | L | A | R | T | R | 0.69 | 0.050 |
| 6 | R | R | I | C | L | S | R | T | R | 0.54 | 0.132 |
| 7 | W | R | I | C | L | A | R | T | R | 0.38 | 0.050 |
| 8 | R | R | I | C | L | A | R | A | R | 0.31 | 0.050 |
| 9 | R | R | L | C | F | A | R | T | R | 0.31 | 0.052 |
| 10 | R | R | L | S | F | A | W | T | R | 0.23 | 0.817 |
| 11 | R | R | L | S | L | A | R | T | R | 0.15 | 0.812 |
| 12 | R | R | I | S | F | A | R | T | R | 0.15 | 0.817 |
| 13 | R | R | L | C | L | A | R | T | K | 0.08 | 0.050 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4D2.aApr07-unspliced | main_exon | 5UTR | chr17 | 58,169,426 | 58,169,656 | + |
| CDS | chr17 | 58,169,656 | 58,170,576 | + | ||
| 3UTR | chr17 | 58,170,576 | 58,171,327 | + | ||