OR52D1 Olfactory Receptor
| Gene Symbol | OR52D11 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | D |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-43, HsOR11.3.68 |
| External Ids | HGNC: 15212 GeneBank: BK004276, NM_001005163 |
| Build #39 labels | OR52D1 |
| Chromosomal location | 11:5,488,707-5,489,660 (+) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs7950082) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52B2 | 58.88% | 304 |
| OR52E8 | 59.81% | 311 |
| OR52S1P | 57.65% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52D1C | 87% | 318 |
| Mouse | Or52d1 | 89% | 308 |
| Rat | Or52d1 | 87% | 314 |
| Cow | OR52D1D | 86% | 318 |
| Cow | OR52D1E | 85% | 318 |
| Orang | OR52D1P | 88% | 330 |
| Horse | OR52D1F | 87% | 318 |
| Chimp | OR52E8 | 59% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136930 |
| GNF Atlas2 | gnf1h05402_at |
Sequence information
| Nucleotide sequence |
ATGTCAGATTCCAACCTCAGTGATAACCATCTTCCAGACACCTTCTTCTTAACAGGGATC CCAGGGCTGGAGGCTGCCCACTTCTGGATTGCCATCCCTTTCTGTGCCATGTATCTTGTA GCACTGGTTGGAAATGCTGCCCTCATCCTGGTCATTGCCATGGACAATGCTCTTCATGCA CCTATGTACCTCTTCCTCTGCCTTCTCTCACTCACAGACCTGGCTCTCAGTTCTACCACT GTGCCCAAGATGCTGGCCATTTTGTGGCTCCATGCTGGTGAGATTTCCTTTGGTGGATGC CTGGCCCAGATGTTTTGTGTCCATTCTATCTATGCTCTGGAGTCCTCAATTCTACTTGCC ATGGCCTTTGATAGGTATGTGGCTATCTGTAACCCATTAAGGTACACAACCATTCTCAAC CATGCTGTCATAGGCAGAATTGGCTTTGTTGGGCTATTCCGTAGTGTGGCTATTGTCTCC CCCTTCATCTTCTTGCTGAGGCGACTCCCCTACTGTGGTCACCGTGTCATGACACACACA TACTGTGAGCATATGGGCATTGCCCGACTGGCCTGTGCCAACATCACTGTCAATATTGTC TATGGGCTAACTGTGGCTCTGCTGGCCATGGGACTGGATTCCATTCTCATTGCCATTTCC TATGGCTTTATCCTCCATGCAGTCTTTCATCTTCCATCTCATGATGCCCAGCACAAAGCT CTGAGTACCTGTGGCTCCCACATTGGCATCATCCTGGTTTTCTACATCCCTGCCTTCTTC TCCTTCCTCACCCACCGCTTTGGTCACCACGAAGTCCCCAAGCATGTGCACATCTTTCTG GCTAATCTCTATGTGCTGGTGCCTCCTGTACTCAATCCTATTCTCTATGGAGCTAGAACC AAGGAGATTCGGAGTCGACTTCTAAAACTGCTTCACCTGGGGAAGACTTCAATA |
| Conceptual translation |
MSDSNLSDNHLPDTFFLTGIPGLEAAHFWIAIPFCAMYLVALVGNAALILVIAMDNALHA PMYLFLCLLSLTDLALSSTTVPKMLAILWLHAGEISFGGCLAQMFCVHSIYALESSILLA MAFDRYVAICNPLRYTTILNHAVIGRIGFVGLFRSVAIVSPFIFLLRRLPYCGHRVMTHT YCEHMGIARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILHAVFHLPSHDAQHKA LSTCGSHIGIILVFYIPAFFSFLTHRFGHHEVPKHVHIFLANLYVLVPPVLNPILYGART KEIRSRLLKLLHLGKTSI Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | C/A | T/N | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | A/G | S/S | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 5,489,054 | 5,489,054 | SYN | A/G | S/S | 1000GP (CEU, CHBJPT) |
| 11 | 5,489,111 | 5,489,111 | SYN | C/T | Y/Y | 1000GP (CEU, CHBJPT) |
| 11 | 5,489,176 | 5,489,176 | NS | C/G | A/G | 1000GP (CHBJPT) |
| 11 | 5,489,181 | 5,489,181 | NS | G/T | V/F | 1000GP (CHBJPT) |
| 11 | 5,489,196 | 5,489,196 | NS | T/A | F/I | 1000GP (CHBJPT) |
| 11 | 5,489,267 | 5,489,267 | SYN | T/C | I/I | 1000GP (CEU, CHBJPT) |
| 11 | 5,489,368 | 5,489,368 | NS | A/T | Y/F | 1000GP (CEU) |
| 11 | 5,489,396 | 5,489,396 | SYN | T/C | H/H | 1000GP (CEU, CHBJPT) |
| 11 | 5,489,458 | 5,489,458 | NS | T/C | I/T | 1000GP (CEU, CHBJPT) |
| 11 | 5,510,284 | 5,510,284 | SYN | G/A | S/S | rs417425 (DbSNP) |
| 11 | 5,510,341 | 5,510,341 | SYN | T/C | Y/Y | rs404280 (DbSNP) |
| 11 | 5,510,396 | 5,510,396 | NS | C/T | R/C | rs7935144 (DbSNP) |
| 11 | 5,510,424 | 5,510,426 | Del(3) | -/TCT | rs35986511 (DbSNP) | |
| 11 | 5,510,430 | 5,510,432 | In-Del(3) | -/AAG | rs58704672 (DbSNP) | |
| 11 | 5,510,497 | 5,510,497 | SYN | C/T | I/I | rs2467219 (DbSNP) |
| 11 | 5,510,542 | 5,510,541 | Ins(4) | -/GGCT | rs72233167 (DbSNP) | |
| 11 | 5,510,543 | 5,510,542 | Ins(4) | -/CTGG | rs36066208 (DbSNP) | |
| 11 | 5,510,546 | 5,510,545 | Ins(4) | -/GGCT | rs71991809 (DbSNP) | |
| 11 | 5,510,575 | 5,510,575 | NS | A/T | E/D | rs7924754 (DbSNP) |
| 11 | 5,510,598 | 5,510,598 | NS | A/T | Y/F | rs7950082 (DbSNP) |
| 11 | 5,510,626 | 5,510,626 | SYN | T/C | H/H | rs444878 (DbSNP) |
| 11 | 5,510,688 | 5,510,688 | NS | C/T | T/I | rs7101919 (DbSNP) |
| 11 | 5,510,846 | 5,510,846 | NS | C/T | R/W | rs11037758 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T137N | R154C | D213E | Y221F | I251T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|
| 1 | T | R | D | Y | I | 70.51 | 0.038 |
| 2 | T | R | D | Y | T | 18.43 | 0.068 |
| 3 | T | R | D | F | I | 8.60 | 1.000 |
| 4 | T | C | E | Y | I | 2.00 | 0.017 |
| 5 | N | R | D | Y | I | 0.46 | 0.038 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52D1.aApr07-unspliced | main_exon | CDS | chr11 | 5,488,707 | 5,489,660 | + |
| 3UTR | chr11 | 5,489,660 | 5,489,663 | + | ||