OR52K2 Olfactory Receptor
| Gene Symbol | OR52K21 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | K |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-7, HsOR11.3.6, ORL3404, ORL3405 |
| External Ids | HGNC: 15223 GeneBank: AB065791, BK004258, NM_001005172 ORDB: ORL3404, ORL3405 |
| Build #39 labels | OR52K2 |
| Chromosomal location | 11:4,449,340-4,450,281 (+) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52K1 | 90.76% | 314 |
| OR52K3P | 86.54% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52K1B | 89% | 313 |
| Dog | OR52K1 | 87% | 314 |
| Mouse | Or52k2 | 88% | 314 |
| Rat | Or52k2 | 88% | 314 |
| Rat | Or52k1 | 86% | 314 |
| Cow | OR52K1 | 88% | 314 |
| Orang | OR52K2BP | 89% | 314 |
| Orang | OR52K1 | 86% | 314 |
| Horse | OR52K1 | 87% | 314 |
| Chimp | OR52K1P | 89% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC137248 |
| GNF Atlas2 | gnf1h10692_at |
Sequence information
| Nucleotide sequence |
ATGTCAGCCTCCAATATCACCTTAACACATCCAACTGCCTTCTTGTTGGTGGGGATTCCA GGCCTGGAACACCTGCACATCTGGATCTCCATCCCTTTCTGCTTAGCATATACACTGGCC CTGCTTGGAAACTGCACTCTCCTTCTCATCATCCAGGCTGATGCAGCCCTCCATGAACCC ATGTACCTCTTTCTGGCCATGTTGGCAGCCATCGACCTGGTCCTTTCCTCCTCAGCACTG CCCAAAATGCTTGCCATATTCTGGTTCAGGGATCGGGAGATAAACTTCTTTGCCTGTCTG GCCCAGATGTTCTTCCTTCACTCCTTCTCCATCATGGAGTCAGCAGTGCTGCTGGCCATG GCCTTTGACCGCTATGTGGCTATCTGCAAGCCACTGCACTACACCAAGGTCCTGACTGGG TCCCTCATCACCAAGATTGGCATGGCTGCTGTGGCCCGGGCTGTGACACTAATGACTCCA CTCCCCTTCCTGCTGAGATGTTTCCACTACTGCCGAGGCCCAGTGATCGCTCACTGCTAC TGTGAACACATGGCTGTGGTGAGGCTGGCGTGTGGGGACACTAGCTTCAACAATATCTAT GGCATCGCTGTGGCCATGTTTATTGTGGTGTTGGACCTGCTCCTTGTTATCCTGTCTTAT ATCTTTATTCTTCAGGCAGTTCTACTGCTTGCCTCTCAGGAGGCCCGCTACAAGGCATTT GGGACATGTGTCTCTCATATAGGTGCCATCTTAGCCTTCTACACAACTGTGGTCATCTCT TCAGTCATGCACCGTGTAGCCCGCCATGCTGCCCCTCATGTCCACATCCTCCTTGCCAAT TTCTATCTGCTCTTCCCACCCATGGTCAATCCCATAATCTATGGTGTCAAGACCAAGCAA ATCCGTGAGAGCATCTTGGGAGTATTCCCAAGAAAGGATATG |
| Conceptual translation |
MSASNITLTHPTAFLLVGIPGLEHLHIWISIPFCLAYTLALLGNCTLLLIIQADAALHEP MYLFLAMLAAIDLVLSSSALPKMLAIFWFRDREINFFACLAQMFFLHSFSIMESAVLLAM AFDRYVAICKPLHYTKVLTGSLITKIGMAAVARAVTLMTPLPFLLRCFHYCRGPVIAHCY CEHMAVVRLACGDTSFNNIYGIAVAMFIVVLDLLLVILSYIFILQAVLLLASQEARYKAF GTCVSHIGAILAFYTTVVISSVMHRVARHAAPHVHILLANFYLLFPPMVNPIIYGVKTKQ IRESILGVFPRKDM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | T/T | 1000GP (YRI, YRI) |
| 11 | 4,450,046 | 4,450,046 | NS | G/A | R/H | 1000GP (CEU, CHBJPT) |
| 11 | 4,450,243 | 4,450,243 | NS | C/T | R/C | 1000GP (CEU, CHBJPT) |
| 11 | 4,450,270 | 4,450,270 | NS | A/G | R/G | 1000GP (CEU) |
| 11 | 4,470,707 | 4,470,707 | SYN | C/T | T/T | rs61735705 (DbSNP) |
| 11 | 4,470,939 | 4,470,939 | NS | C/T | R/C | rs11032296 (DbSNP) |
| 11 | 4,470,950 | 4,470,950 | SYN | C/T | A/A | rs61747517 (DbSNP) |
| 11 | 4,471,276 | 4,471,276 | NS | G/A | R/H | rs331537 (DbSNP) |
| 11 | 4,471,393 | 4,471,393 | NS | A/T | H/L | rs61998219 (DbSNP) |
| 11 | 4,471,469 | 4,471,469 | NS | A/C | Q/H | rs61997232 (DbSNP) |
| 11 | 4,471,473 | 4,471,473 | NS | C/T | R/C | rs7934336 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 84 (Hasin) | |||
| 11 | 4,055,945 | 4,510,188 | CopyNumber | Variation_3834 (DGV) |
| 11 | 4,333,543 | 4,474,341 | CopyNumber | Variation_2164 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| W28R | R124C | R236H | H275L | Q300H | R302C | R311G | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | W | R | R | H | Q | R | R | 75.04 | 0.038 |
| 2 | W | R | H | H | Q | C | R | 14.13 | 0.032 |
| 3 | W | R | H | H | Q | R | R | 4.84 | 0.032 |
| 4 | W | C | H | H | Q | R | R | 3.53 | 0.369 |
| 5 | W | R | R | H | H | R | R | 1.08 | 0.038 |
| 6 | W | R | R | H | Q | R | G | 0.54 | 0.038 |
| 7 | W | C | R | H | Q | R | R | 0.38 | 0.415 |
| 8 | R | R | R | H | Q | R | R | 0.23 | 0.038 |
| 9 | W | R | H | L | Q | R | R | 0.08 | 0.032 |
| 10 | W | R | R | H | Q | C | R | 0.08 | 0.038 |
| 11 | W | C | H | L | Q | R | R | 0.08 | 0.369 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52K2.aApr07-unspliced | main_exon | CDS | chr11 | 4,449,340 | 4,450,281 | + |
| 3UTR | chr11 | 4,450,281 | 4,450,284 | + | ||