HORDE's user guide
enter gene symbol, accession number, or free text (e.g. Segregating Pseudo Gene, rs2073150) on the Search Olfactory receptors box and click the Search button. Note that the search system is case sensitive.
Other search tools
Select for a group of ORs- Using the Select ORs from tool, the user can select for a group of ORs based on a shared chromosomal location, or classification. For example, inserting the number "1" for the family , results in a list of all ORs from family 1.
BLAST search- click the For Blast Search click here link, at the top panel to access the BLAST sequence search tool. This provides access to a large collection of OR repertoires that we have included within HORDE.
Model organisms- use the Browse Other Species tool, at the butom left side of the homepage to view ORs from other mammalian species.
The Human OR card- The OR card includes annotation relevant to the gene, with links to internal tools and to appropriate external databases. The OR card sections include: Gene Nomenclature and Phylogeny, Mapping, OR Paralogs and Orthologs, Sequence information, genetic polymorphisms, Haplotypes and gene model.
Protein domains and features- functional annotation of the OR protein is available by clicking the protein domains and features in the sequence information of the OR card. The annotation includes the seven transmembrane domains, positions suspected as the putative odorant binding site residues, a conserved N-glycosylation site, and two conserved cysteines that are predicted to form a disulfide bond between extracellular loops 1 and 2.
Nonhuman OR card- Non-human OR cards include information on gene classification, alias (when available), genomic location and sequence.
UCSC custom track- A link to a UCSC HORDE custom track presenting the gene is available in the Chromosomal location part of the OR card.
CORP- The probabilistic Classifier for Olfactory Receptor Pseudogenes (CORP) algorithm computes the probability of an OR gene with intact open reading frame to encode a nonfunctional protein (i.e., a pseudogene) by examining the deviation of its protein sequences from the OR functionally crucial consensus. It accepts as an input an OR protein sequence and returns the pseudogene probability score of the gene.
CLICs- CLIC (Cluster In Conservation) is a tool for genome-wide definition of genomic gene clusters conserved in multiple species. The CLIC algorithm was applied to the ORs of five mammals. 48 multispecies CLICs were discovered, covering more than 90% of all OR genes. The CLIC Web page contains a list of all CLICs and full details of the ORs participating in each CLIC from all compared species.