OR10A6 Olfactory Receptor
| Gene Symbol | OR10A61 (View this gene in GeneCards) |
| Family | 10 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-96, HsOR11.5.7, ORL3414 |
| External Ids | HGNC: 15132 GeneBank: AB065515, AB065588, BK004403, NM_001004461 ORDB: ORL3414 |
| Build #39 labels | OR10A6 |
| Chromosomal location | 11:7,927,721-7,928,662 (-) |
| Cluster | 11@8 |
| Synteny | CLIC#25 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs4758258) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR10A3 | 85.3% | 313 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR10A3E | 83% | 312 |
| Dog | OR10A3 | 82% | 313 |
| Mouse | Or10a49 | 79% | 313 |
| Rat | Or10a49 | 79% | 313 |
| Cow | OR10A6P | 85% | 312 |
| Cow | OR10A3 | 84% | 313 |
| Cow | OR10A3F | 82% | 313 |
| Orang | OR10A3J | 85% | 314 |
| Orang | OR10A3 | 84% | 314 |
| Orang | OR10A3K | 82% | 314 |
| Horse | OR10A3 | 84% | 313 |
| Horse | OR10A3L | 83% | 313 |
| Chimp | OR10A3P | 84% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BQ012254 |
| mRNA | AB529270 |
| GNF Atlas2 | gnf1h05429_at |
Sequence information
| Nucleotide sequence |
ATGGAAAGACAAAATCAAAGCTGTGTGGTTGAATTCATCCTCTTGGGCTTTTCTAACTAT CCTGAGCTCCAGGGGCAGCTCTTTGTGGCTTTCCTGGTTATTTATCTGGTGACCCTGATA GGAAATGCCATTATTATAGTCATCGTCTCCCTAGACCAGAGCCTCCACGTTCCCATGTAC CTGTTTCTCCTGAACTTATCTGTGGTGGACCTGAGTTTCAGTGCAGTTATTATGCCTGAA ATGCTGGTGGTCCTCTCTACTGAAAAAACTACAATTTCTTTTGGGGGCTGTTTTGCACAG ATGTATTTCATCCTTCTTTTTGGTGGGGCTGAATGTTTTCTTCTGGGAGCAATGGCTTAT GACCGATTTGCTGCAATTTGCCATCCTCTCAACTACCAAATGATTATGAATAAAGGAGTT TTTATGAAATTAATTATATTTTCATGGGCCTTAGGTTTTATGTTAGGTACTGTTCAAACA TCATGGGTATCTAGTTTTCCCTTTTGTGGCCTTAATGAAATTAACCATATATCTTGTGAA ACCCCAGCAGTGTTAGAACTTGCATGTGCAGACACGTTTTTGTTTGAAATCTATGCATTC ACAGGCACCTTTTTGATTATTTTGGTTCCTTTCTTGTTGATACTCTTGTCTTACATTCGA GTTCTGTTTGCCATCCTGAAGATGCCATCAACCACTGGGAGACAAAAGGCCTTTTCCACC TGTGCCGCTCACCTCACATCTGTGACCCTATTCTATGGCACAGCCAGTATGACTTATTTA CAACCCAAATCTGGCTACTCACCGGAAACCAAGAAAGTGATGTCATTGTCTTACTCACTT CTGACACCACTGCTGAATCTGCTTATCTACAGTTTGCGAAATAGTGAGATGAAGAGGGCT TTGATGAAATTATGGCGAAGGCGAGTGGTTTTACACACAATC |
| Conceptual translation |
MERQNQSCVVEFILLGFSNYPELQGQLFVAFLVIYLVTLIGNAIIIVIVSLDQSLHVPMY LFLLNLSVVDLSFSAVIMPEMLVVLSTEKTTISFGGCFAQMYFILLFGGAECFLLGAMAY DRFAAICHPLNYQMIMNKGVFMKLIIFSWALGFMLGTVQTSWVSSFPFCGLNEINHISCE TPAVLELACADTFLFEIYAFTGTFLIILVPFLLILLSYIRVLFAILKMPSTTGRQKAFST CAAHLTSVTLFYGTASMTYLQPKSGYSPETKKVMSLSYSLLTPLLNLLIYSLRNSEMKRA LMKLWRRRVVLHTI Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 7,949,791 | 7,949,791 | NS | A/C | V/G | rs7933807 (DbSNP) |
| 11 | 7,949,860 | 7,949,860 | NS | A/G | V/A | rs7928451 (DbSNP) |
| 11 | 7,949,350 | 7,949,350 | NS | A/G | L/P | rs4758258 (DbSNP) |
| 11 | 7,950,024 | 7,950,024 | SYN | A/G | F/F | rs12272735 (DbSNP) |
| 11 | 7,928,477 | 7,928,477 | SYN | A/G | F/F | 1000GP (CEU, CHBJPT) |
| 11 | 7,928,244 | 7,928,244 | NS | A/C | V/G | 1000GP (CEU, CHBJPT) |
| 11 | 7,927,721 | 7,927,721 | SYN | G/T | I/I | 1000GP (CEU) |
| 11 | 7,927,803 | 7,927,803 | NS | A/G | L/P | 1000GP (CEU, CHBJPT) |
| 11 | 7,928,160 | 7,928,160 | NS | A/G | F/S | 1000GP (CEU) |
| 11 | 7,928,121 | 7,928,121 | NS | G/C | T/S | 1000GP (CEU) |
| 11 | 7,928,313 | 7,928,313 | NS | G/A | A/V | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | A/G | L/P | 1000GP (YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | A/G | F/F | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R306* | L287P | S247P | F168S | V140G | A117V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | R | P | S | F | G | V | 37.33 | 0.098 |
| 2 | R | P | S | F | V | A | 35.02 | 0.098 |
| 3 | R | L | S | F | V | A | 21.81 | 0.793 |
| 4 | R | P | S | F | G | A | 1.92 | 0.098 |
| 5 | * | L | S | F | V | A | 1.23 | 1.200 |
| 6 | R | P | S | S | G | V | 0.92 | 0.304 |
| 7 | R | P | S | S | V | A | 0.46 | 0.304 |
| 8 | R | L | P | F | V | A | 0.46 | 0.793 |
| 9 | R | L | S | F | G | V | 0.38 | 0.793 |
| 10 | * | L | S | F | G | A | 0.15 | 1.200 |
| 11 | R | P | S | F | V | V | 0.15 | 0.098 |
| 12 | R | L | S | F | V | V | 0.08 | 0.793 |
| 13 | R | L | S | S | V | A | 0.08 | 0.939 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR10A6.aApr07-unspliced | main_exon | 3UTR | chr11 | 7,927,634 | 7,927,721 | - |
| CDS | chr11 | 7,927,721 | 7,928,662 | - | ||