OR14I1 Olfactory Receptor
| Gene Symbol | OR14I11 (View this gene in GeneCards) |
| Family | 14 |
| Subfamily | I |
| Pseudogene | No |
| CORP pseudogene probability score | 0.8 (pseudogene) |
| Aliases | HsOR1.5.50 |
| External Ids | HGNC: 19575 |
| Build #39 labels | OR5BU1P |
| Chromosomal location | 1:248,681,372-248,682,304 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#0 |
| Remarks | Belongs to OR14- a new family which is expanded in opossum and platypus. Was previously classified into family 5 with the symbol OR5BU1. |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR14C36 | 49.35% | 308 |
| OR14A16 | 53.64% | 302 |
| OR14A2 | 48.53% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR14I2 | 78% | 310 |
| Mouse | Or14p1 | 51% | 303 |
| Rat | Or14p1 | 51% | 301 |
| Cow | OR14J12 | 51% | 312 |
| Orang | OR14I1P | 95% | 311 |
| Orang | OR14I1D | 93% | 307 |
| Horse | OR14I7P | 73% | 311 |
| Chimp | OR14A262 | 56% | 302 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | AI911102 |
| mRNA | BC137189 |
Sequence information
| Nucleotide sequence |
ATGGACAATCTCACAAAAGTGACAGAATTCCTGCTGATGGAGTTTTCTGGTATCTGGGAG CTGCAGGTGCTGCACGCCGGGCTGTTTCTGCTGATTTATCTGGCAGTGCTGGTGGGGAAC CTGCTCATCATTGCAGTCATCACTCTCGATCAGCATCTTCACACACCCATGTACTTCTTC CTGAAGAACCTCTCCGTTTTGGATCTGTGCTACATCTCAGTCACTGTGCCTAAATCCATC CGTAACTCCCTGACTCGCAGAAGCTCCATCTCTTATCTTGGCTGTGTGGCTCAAGTCTAT TTTTTCTCTGCCTTTGCATCTGCTGAGCTGGCCTTCCTTACTGTCATGTCTTATGACCGC TATGTTGCCATTTGCCACCCCCTCCAATACAGAGCCGTGATGACATCAGGAGGGTGCTAT CAGATGGCAGTCACCACCTGGCTAAGCTGCTTTTCCTACGCAGCCGTCCACACTGGCAAC ATGTTTCGGGAGCACGTTTGCAGATCCAGTGTGATCCACCAGTTCTTCCGTGACATCCCT CATGTGTTGGCCCTGGTTTCCTGTGAGGTTTTCTTTGTAGAGTTTTTGACCCTGGCCCTG AGCTCATGCTTGGTTCTGGGATGCTTTATTCTCATGATGATCTCCTATTTCCAAATCTTC TCAACGGTGCTCAGAATCCCTTCAGGACAGAGTCGAGCAAAAGCCTTCTCCACCTGCTCC CCCCAGCTCATTGTCATCATGCTCTTTCTTACCACAGGGCTCTTTGCTGCCTTAGGACCA ATTGCAAAAGCTCTGTCCATTCAGGATTTAGTGATTGCTCTGACATACACAGTTTTGCCT CCCTTCCTCAATCCCATCATATATAGTCTTAGGAATAAGGAGATTAAAACAGCCATGTGG AGACTCTTTGTGAAGATATATTTTCTGCAAAAG |
| Conceptual translation |
MDNLTKVTEFLLMEFSGIWELQVLHAGLFLLIYLAVLVGNLLIIAVITLDQHLHTPMYFF LKNLSVLDLCYISVTVPKSIRNSLTRRSSISYLGCVAQVYFFSAFASAELAFLTVMSYDR YVAICHPLQYRAVMTSGGCYQMAVTTWLSCFSYAAVHTGNMFREHVCRSSVIHQFFRDIP HVLALVSCEVFFVEFLTLALSSCLVLGCFILMMISYFQIFSTVLRIPSGQSRAKAFSTCS PQLIVIMLFLTTGLFAALGPIAKALSIQDLVIALTYTVLPPFLNPIIYSLRNKEIKTAMW RLFVKIYFLQK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | A/T | V/E | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | G/A | S/S | 1000GP (YRI, YRI) |
| 1 | 248,681,658 | 248,681,658 | NS | T/C | Y/C | 1000GP (CEU, CHBJPT) |
| 1 | 248,681,796 | 248,681,796 | NS | C/T | S/N | 1000GP (CEU, CHBJPT) |
| 1 | 248,682,055 | 248,682,055 | NS | G/T | L/M | 1000GP (CEU, CHBJPT) |
| 1 | 248,682,110 | 248,682,110 | SYN | G/A | S/S | 1000GP (CEU, CHBJPT) |
| 1 | 248,682,157 | 248,682,157 | NS | C/T | D/N | 1000GP (CEU, CHBJPT) |
| 1 | 248,682,170 | 248,682,170 | SYN | T/C | A/A | 1000GP (CEU, CHBJPT) |
| 1 | 248,682,198 | 248,682,198 | NS | A/G | V/A | 1000GP (CEU, CHBJPT) |
| 1 | 248,844,959 | 248,844,959 | SNP | C/T | rs55871516 (DbSNP) | |
| 1 | 248,845,097 | 248,845,097 | SNP | T/C | rs2000390 (DbSNP) | |
| 1 | 248,845,356 | 248,845,356 | SNP | G/T | rs41311583 (DbSNP) | |
| 1 | 248,845,411 | 248,845,411 | SNP | A/G | rs11485825 (DbSNP) | |
| 1 | 248,845,458 | 248,845,458 | SNP | C/T | rs4509608 (DbSNP) | |
| 1 | 248,845,471 | 248,845,471 | SNP | C/T | rs4575113 (DbSNP) | |
| 1 | 248,845,499 | 248,845,499 | SNP | A/G | rs4462184 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,500,109 | 248,865,374 | CopyNumber | Variation_3340 (DGV) |
| 1 | 248,522,680 | 249,158,239 | CopyNumber | Variation_8355 (DGV) |
| 1 | 248,687,510 | 248,865,377 | CopyNumber | Variation_0017 (DGV) |
| 1 | 248,701,948 | 248,877,423 | CopyNumber | Variation_2056 (DGV) |
| 1 | 248,837,759 | 248,882,120 | CopyNumber | Variation_34798 (DGV) |
| 1 | 248,842,825 | 248,845,785 | CopyNumber | Variation_6819 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V304E | Y216C | V205L | S170N | L84M | D50N | V36A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | V | Y | V | N | L | N | A | 73.20 | 0.851 |
| 2 | V | C | V | S | M | D | A | 11.21 | 1.000 |
| 3 | V | Y | V | S | L | D | V | 7.45 | 0.851 |
| 4 | E | C | V | S | L | D | A | 2.53 | 1.000 |
| 5 | V | Y | V | N | M | D | A | 2.07 | 0.851 |
| 6 | V | Y | V | S | L | D | A | 0.84 | 0.851 |
| 7 | V | Y | V | S | L | N | A | 0.69 | 0.851 |
| 8 | V | Y | L | S | L | D | V | 0.46 | 0.851 |
| 9 | V | C | V | S | L | N | A | 0.38 | 1.000 |
| 10 | V | Y | V | S | M | D | A | 0.31 | 0.851 |
| 11 | V | C | V | S | M | N | A | 0.15 | 1.000 |
| 12 | V | Y | V | N | L | D | V | 0.15 | 0.851 |
| 13 | V | Y | V | S | M | N | A | 0.15 | 0.851 |
| 14 | V | C | V | S | L | D | V | 0.08 | 1.000 |
| 15 | V | Y | V | S | L | N | V | 0.08 | 0.851 |
| 16 | E | Y | V | N | L | N | A | 0.08 | 0.851 |
| 17 | V | Y | V | N | L | D | A | 0.08 | 0.851 |
| 18 | V | Y | V | N | L | N | V | 0.08 | 0.851 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5BU1.aApr07-unspliced | main_exon | 3UTR | chr1 | 248,681,124 | 248,681,372 | - |
| CDS | chr1 | 248,681,372 | 248,682,304 | - | ||