OR2B2 Olfactory Receptor
| Gene Symbol | OR2B21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR6-2, OR6-1, dJ193B12.4, HsOR6.2.1, ORL681, ORL680, ORL1019 |
| External Ids | HGNC: 13966 GeneBank: BK004361, HSA302584-HSA302593, NM_033057 ORDB: ORL681, ORL680, ORL1019 |
| Build #39 labels | OR2B2 |
| Chromosomal location | 6:27,911,249-27,912,319 (-) |
| Cluster | 6@28a |
| Synteny | CLIC#12 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2B6 | 81.61% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2B10P | 72% | 303 |
| Mouse | Or2b2 | 86% | 313 |
| Mouse | Or2b2b | 86% | 313 |
| Rat | Or2b2 | 84% | 310 |
| Cow | OR2B2D | 85% | 314 |
| Orang | OR2B6 | 81% | 313 |
| Horse | OR2B6 | 82% | 313 |
| Chimp | OR2B2P | 96% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | N68399 |
| mRNA | BC136901 |
| GNF Atlas2 | 216408_at |
Sequence information
| Nucleotide sequence |
ATGAATTGGGTAAATAAGAGTGTCCCACAGGAGTTCATTCTGTTAGTTTTCTCAGATCAA CCATGGCTAGAGATTCCACCCTTTGTGATGTTTCTGTTTTCCTATATCTTGACAATCTTT GGCAATCTGACAATAATTCTTGTGTCACATGTGGATTTCAAACTCCACACCCCTATGTAC TTTTTTCTTAGCAATCTCTCACTCCTGGACCTTTGCTATACCACAAGTACAGTTCCACAA ATGCTGGTAAACATATGCAACACCAGGAAAGTAATCAGTTATGGTGGCTGTGTGGCCCAG CTTTTCATTTTCCTGGCCTTGGGTTCCACAGAATGTCTTCTCCTGGCCGTCATGTGCTTT GATAGGTTTGTAGCTATTTGTCGGCCTCTCCATTACTCAATTATCATGCACCAGAGGCTC TGCTTCCAGTTGGCAGCTGCATCCTGGATTAGTGGCTTTAGCAATTCAGTATTACAGTCC ACCTGGACACTTAAGATGCCACTGTGTGGTCACAAAGAAGTGGATCACTTCTTCTGTGAA GTCCCTGCTCTGCTCAAGTTGTCCTGTGTTGACACAACAGCAAATGAGGCTGAACTATTC TTCATCAGTGTGCTATTCCTTCTAATACCCGTGACACTCATCCTTATATCGTATGCTTTT ATTGTCCAAGCAGTGTTGAGAATCCAGTCTGCTGAAGGTCAACGAAAGGCATTTGGGACA TGTGGCTCCCATCTAATTGTGGTGTCACTTTTTTATGGTACAGCTATCTCCATGTACCTG CAACCACCTTCACCCAGCTCCAAAGACCGGGGAAAGATGGTTTCTCTCTTCTGTGGAATC ATTGCACCCATGCTGAATCCCCTTATATATACACTTAGGAACAAAGAGGTAAAGGAAGCC TTTAAAAGGTTGGTTGCAAAGAGTCTTCTTAATCAAGAAATAAGAAATATGCAAATGATA AGCTTTGCTAAAGACACAGTGCTTACTTACCTTACTAACTTCTCCGCAAGTTGTCCTATT TTTGTCATTACTATAGAAAACTATTGTAATCTCCCTCAAAGAAAATTTCCT |
| Conceptual translation |
MNWVNKSVPQEFILLVFSDQPWLEIPPFVMFLFSYILTIFGNLTIILVSHVDFKLHTPMY FFLSNLSLLDLCYTTSTVPQMLVNICNTRKVISYGGCVAQLFIFLALGSTECLLLAVMCF DRFVAICRPLHYSIIMHQRLCFQLAAASWISGFSNSVLQSTWTLKMPLCGHKEVDHFFCE VPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIQSAEGQRKAFGT CGSHLIVVSLFYGTAISMYLQPPSPSSKDRGKMVSLFCGIIAPMLNPLIYTLRNKEVKEA FKRLVAKSLLNQEIRNMQMISFAKDTVLTYLTNFSASCPIFVITIENYCNLPQRKFP Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 6 | 27,879,200 | 27,879,200 | NS | A/C | S/A | rs34788973 (DbSNP) |
| 6 | 27,879,982 | 27,879,982 | NS | A/G | I/T | rs61742093 (DbSNP) |
| 6 | 27,879,551 | 27,879,551 | NS | C/G | A/P | rs9368537 (DbSNP) |
| 6 | 27,879,397 | 27,879,397 | NS | C/T | R/Q | rs34957169 (DbSNP) |
| 6 | 27,879,869 | 27,879,869 | NS | G/T | P/T | rs35712782 (DbSNP) |
| 6 | 27,879,093 | 27,879,093 | SYN | A/G | S/S | rs73392698 (DbSNP) |
| 6 | 27,911,773 | 27,911,773 | NS | C/G | A/P | 1000GP (CEU, CHBJPT) |
| 6 | 27,911,619 | 27,911,619 | NS | T/C | Q/R | 1000GP (CEU) |
| 6 | 27,911,422 | 27,911,422 | NS | C/A | A/S | 1000GP (CEU) |
| 6 | 27,912,204 | 27,912,204 | NS | A/G | I/T | 1000GP (CEU) |
| 6 | 27,911,670 | 27,911,670 | NS | G/A | S/L | 1000GP (CHBJPT) |
| 6 | 100 | -100 | SYN | G/A | S/S | 1000GP (YRI) |
| 6 | 100 | -100 | NS | T/C | Q/R | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 68 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Y348F | A300S | R270Q | Q234R | S217L | A183P | T77P | S76G | I39T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Y | A | R | Q | S | A | T | S | I | 87.17 | 0.449 |
| 2 | Y | A | R | Q | S | P | T | S | I | 4.61 | 0.449 |
| 3 | Y | S | R | Q | S | A | T | S | T | 3.61 | 0.449 |
| 4 | Y | A | R | R | S | A | T | S | I | 3.07 | 0.449 |
| 5 | Y | A | R | Q | L | P | T | S | I | 0.38 | 0.707 |
| 6 | Y | A | R | Q | S | A | P | S | I | 0.38 | 0.449 |
| 7 | F | A | R | Q | S | A | T | S | I | 0.31 | 0.449 |
| 8 | Y | A | Q | Q | S | A | T | S | I | 0.23 | 0.449 |
| 9 | Y | S | R | Q | S | A | T | S | I | 0.15 | 0.449 |
| 10 | Y | A | R | Q | S | A | T | G | I | 0.08 | 0.449 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2B2.aApr07-unspliced | main_exon | 3UTR | chr6 | 27,911,246 | 27,911,249 | - |
| CDS | chr6 | 27,911,249 | 27,912,319 | - | ||
| 5UTR | chr6 | 27,912,319 | 27,912,558 | - | ||