OR2C1 Olfactory Receptor
| Gene Symbol | OR2C11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.34 (functional) |
| Aliases | OR16-1, OR16-2, OLFmf3, OR2C1, HsOR16.1.3, ORL423 |
| External Ids | HGNC: 8242 GeneBank: AF098664, AF399497, BC069158, BK004407, BK004428, NM_012368 ORDB: ORL423 |
| Build #39 labels | OR2C2P, OR2C1 |
| Chromosomal location | 16:3,355,941-3,356,876 (+) |
| Cluster | 16@3a |
| Synteny | CLIC#38 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2C3 | 58.03% | 305 |
| OR2G3 | 60.8% | 301 |
| OR2W6P | 60.86% | 304 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2G3P | 60% | 307 |
| Mouse | Or2c1 | 83% | 309 |
| Rat | Or2c1 | 85% | 307 |
| Cow | OR2G3 | 61% | 308 |
| Orang | OR2H2P | 60% | 304 |
| Horse | OR2G28 | 63% | 303 |
| Chimp | OR2G3 | 61% | 306 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EL736268 |
| mRNA | CU686823 |
| GNF Atlas2 | 221460_at |
Sequence information
| Nucleotide sequence |
ATGGACGGGGTGAATGATAGCTCCTTGCAGGGCTTTGTTCTGATGGGCATATCAGACCAT CCCCAGCTGGAGATGATCTTTTTTATAGCCATCCTCTTCTCCTATTTGCTGACCCTACTT GGGAACTCAACCATCATCTTGCTTTCCCGCCTGGAGGCCCGGCTCCATACACCCATGTAC TTCTTCCTCAGCAACCTCTCCTCCTTGGACCTTGCTTTCGCTACTAGTTCAGTCCCCCAA ATGCTGATCAATTTATGGGGACCAGGCAAGACCATCAGCTATGGTGGCTGCATAACCCAG CTCTATGTCTTCCTTTGGCTGGGGGCCACCGAGTGCATCCTGCTGGTGGTGATGGCATTT GACCGCTACGTGGCAGTGTGCCGGCCCCTCCGCTACACCGCCATCATGAACCCCCAGCTC TGCTGGCTGCTGGCTGTGATTGCCTGCCTGGGTGGCTTGGGCAACTCTGTGATCCAGTCA ACATTCACTCTGCAGCTCCCATTGTGTGGGCACCGGAGGGTGGAGGGATTCCTCTGCGAG GTGCCTGCCATGATCAAACTGGCCTGTGGCGACACAAGTCTCAACCAGGCTGTGCTCAAT GGTGTCTGCACCTTCTTCACTGCAGTCCCACTAAGCATCATCGTGATCTCCTACTGCCTC ATTGCTCAGGCAGTGCTGAAAATCCGCTCTGCAGAGGGGAGGCGAAAGGCGTTCAATACG TGCCTCTCCCATCTGCTGGTGGTGTTCCTCTTCTATGGCTCAGCCAGCTATGGGTATCTG CTTCCGGCCAAGAACAGCAAACAGGACCAGGGCAAGTTCATTTCCCTGTTCTACTCGTTG GTCACACCCATGGTGAATCCCCTCATCTACACGCTGCGGAACATGGAAGTGAAGGGCGCA CTGAGGAGGTTGCTGGGGAAAGGAAGAGAAGTTGGC |
| Conceptual translation |
MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMY FFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAF DRYVAVCRPLRYTAIMNPQLCWLLAVIACLGGLGNSVIQSTFTLQLPLCGHRRVEGFLCE VPAMIKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVLKIRSAEGRRKAFNT CLSHLLVVFLFYGSASYGYLLPAKNSKQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGA LRRLLGKGREVG Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 16 | 100 | -100 | NS | G/A | G/S | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 16 | 100 | -100 | SYN | A/G | S/S | 1000GP (YRI, YRI, YRI, YRI) |
| 16 | 3,355,986 | 3,355,986 | NS | G/A | G/S | 1000GP (CEU, CHBJPT) |
| 16 | 3,355,994 | 3,355,994 | SYN | A/G | S/S | 1000GP (CEU, CHBJPT) |
| 16 | 3,356,112 | 3,356,112 | NS | C/T | P/S | 1000GP (CHBJPT) |
| 16 | 3,356,387 | 3,356,387 | NS | C/G | C/W | 1000GP (CEU) |
| 16 | 3,356,516 | 3,356,516 | SYN | A/G | T/T | 1000GP (CEU, CHBJPT) |
| 16 | 3,356,626 | 3,356,626 | NS | G/A | R/H | 1000GP (CEU, CHBJPT) |
| 16 | 3,356,838 | 3,356,838 | NS | G/A | A/T | 1000GP (CEU) |
| 16 | 3,405,986 | 3,405,986 | NS | A/G | S/G | rs1218762 (DbSNP) |
| 16 | 3,405,994 | 3,405,994 | SYN | A/G | S/S | rs1228348 (DbSNP) |
| 16 | 3,406,019 | 3,406,019 | NS | C/T | L/F | rs62000971 (DbSNP) |
| 16 | 3,406,158 | 3,406,158 | Del(1) | -/T | rs5815169 (DbSNP) | |
| 16 | 3,406,358 | 3,406,358 | NS | C/T | L/F | rs62000972 (DbSNP) |
| 16 | 3,406,387 | 3,406,387 | NS | C/G | C/W | rs1218763 (DbSNP) |
| 16 | 3,406,446 | 3,406,446 | NS | A/G | Y/C | rs62000973 (DbSNP) |
| 16 | 3,406,516 | 3,406,516 | SYN | A/G | T/T | rs11643487 (DbSNP) |
| 16 | 3,406,564 | 3,406,564 | SYN | A/T | A/A | rs62000974 (DbSNP) |
| 16 | 3,406,626 | 3,406,626 | NS | A/G | H/R | rs11648783 (DbSNP) |
| 16 | 3,406,838 | 3,406,838 | NS | A/G | T/A | rs62000975 (DbSNP) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G16S | P58S | C169Y | R172W | E180K | R229H | P262L | A300T | G312D | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | P | C | R | E | R | P | A | G | 70.28 | 0.563 |
| 2 | S | P | C | R | E | H | P | A | G | 24.19 | 0.563 |
| 3 | G | S | C | R | E | R | P | A | G | 2.07 | 0.733 |
| 4 | S | P | Y | R | E | H | P | A | G | 1.31 | 0.563 |
| 5 | G | P | C | R | E | R | P | A | D | 0.84 | 0.563 |
| 6 | G | P | C | R | E | R | P | T | G | 0.69 | 0.563 |
| 7 | G | P | C | W | E | R | P | A | G | 0.15 | 0.563 |
| 8 | G | P | C | R | E | R | L | A | G | 0.15 | 0.563 |
| 9 | G | P | C | R | E | H | P | A | G | 0.15 | 0.563 |
| 10 | S | P | C | R | K | H | P | A | G | 0.08 | 0.563 |
| 11 | G | P | C | R | K | R | P | A | G | 0.08 | 0.563 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2C1.aApr07-unspliced | main_exon | 5UTR | chr16 | 3,355,889 | 3,355,941 | + |
| CDS | chr16 | 3,355,941 | 3,356,876 | + | ||
| 3UTR | chr16 | 3,356,876 | 3,356,924 | + | ||