OR2M5 Olfactory Receptor
| Gene Symbol | OR2M51 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | M |
| Pseudogene | No |
| CORP pseudogene probability score | 0 (functional) |
| Aliases | HsOR1.5.29 |
| External Ids | HGNC: 19576 GeneBank: NM_001004690 |
| Build #39 labels | OR2M5P |
| Chromosomal location | 1:248,145,148-248,146,083 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2M2 | 91.26% | 309 |
| OR2M3 | 92.95% | 312 |
| OR2M7 | 92.63% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2M9 | 78% | 312 |
| Mouse | Or2m12 | 72% | 309 |
| Rat | Or2m12 | 74% | 307 |
| Cow | OR2M10 | 75% | 312 |
| Orang | OR2M5P | 93% | 312 |
| Orang | OR2M3P | 92% | 306 |
| Horse | OR2M24 | 77% | 312 |
| Chimp | OR2M7 | 93% | 312 |
| Chimp | OR2M3 | 92% | 312 |
| Chimp | OR2M2 | 91% | 312 |
Sequence information
| Nucleotide sequence |
ATGGCATGGGAGAATCAGACCTTCAACTCTGACTTCATCCTCCTGGGAATCTTCAATCAC AGCCCCACCCACACCTTCCTCTTCTTTCTGGTCCTGGCCATCTTTTCAGTGGCCTTCATG GGAAACTCTGTCATGGTTCTCCTCATCTACCTGGACACCCAGCTCCACACCCCCATGTAC TTCCTCCTCAGTCAACTGTTCCTCATGGACCTCATGCTCATCTGCTCTACCGTACCCAAG ATGGCCTTCAACTACTTGTCTGGCAGCAAGTCCATTTCTATGGCTGGTTGTGCCACACAA ATTTTCTTCTATGTATCACTGCTTGGCTCCGAATGCTTTCTGTTGGCTGTTATGTCTTAT GACCGCTATATTGCCATTTGCCACCCTCTAAGATACACCAATCTCATGAGACCCAAAATT TGTGGACTTATGACTGCCTTCTCCTGGATCCTGGGCTCTATGGATGCAATCATTGATGCT GTAGCGACATTTTCCTTCTCCTACTGTGGGTCTCGGGAAATAGCCCACTTCTTCTGTGAC TTCCCTTCCCTACTAATCCTCTCATGCAATGACACATCAATATTTGAAAAGGTTCTTTTC ATCTGCTGTATAGTAATGATTGTTTTTCCTGTTGCAATCATCATCGCTTCCTATGCTCGA GTTATTCTGGCTGTCATTCACATGGGATCTGGAGAGGGTCGTCGCAAAGCTTTTACTACC TGTTCCTCTCACCTCATGGTGGTGGGAATGTACTATGGAGCAGGTTTGTTCATGTACATA CGGCCCACATCTGATCGCTCCCCTATGCAGGACAAGCTGGTGTCTGTATTCTACACCATC CTCACTCCCATGCTGAATCCCCTCATCTACAGCCTCCGCAACAAGGAGGTGACCAGAGCA CTCAGGAAAGTGTTAGGAAAGGGCAAGTGTGGAGAG |
| Conceptual translation |
MAWENQTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMY FLLSQLFLMDLMLICSTVPKMAFNYLSGSKSISMAGCATQIFFYVSLLGSECFLLAVMSY DRYIAICHPLRYTNLMRPKICGLMTAFSWILGSMDAIIDAVATFSFSYCGSREIAHFFCD FPSLLILSCNDTSIFEKVLFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTT CSSHLMVVGMYYGAGLFMYIRPTSDRSPMQDKLVSVFYTILTPMLNPLIYSLRNKEVTRA LRKVLGKGKCGE Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,308,436 | 248,308,436 | large insertion | 57477bp insertion | rs72482063 (DbSNP) | |
| 1 | 248,309,159 | 248,309,159 | NS | A/C | D/A | rs41304157 (DbSNP) |
| 1 | 248,308,933 | 248,308,933 | NS | A/G | T/A | rs59407768 (DbSNP) |
| 1 | 248,309,356 | 248,309,356 | NS | A/G | K/E | rs73141283 (DbSNP) |
| 1 | 248,309,107 | 248,309,107 | NS | C/G | R/G | rs41305578 (DbSNP) |
| 1 | 248,146,054 | 248,146,054 | NS | A/G | K/E | 1000GP (CEU, CHBJPT) |
| 1 | 248,145,614 | 248,145,614 | NS | C/G | A/G | 1000GP (CEU) |
| 1 | 100 | -100 | SYN | A/T | S/S | 1000GP (YRI, YRI) |
| 1 | 100 | -100 | NS | A/G | K/E | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,242,528 | 248,817,382 | CopyNumber | Variation_8935 (DGV) |
| 1 | 248,308,350 | 248,311,385 | CopyNumber | #30 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G16R | M144T | A162V | A216T | R220P | M228V | R235H | A237D | L292V | K303E | L305* | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | M | A | A | R | M | R | A | L | K | L | 87.79 | 0.009 |
| 2 | G | M | A | A | R | M | R | A | L | E | L | 6.61 | 0.009 |
| 3 | G | M | V | A | R | M | R | D | L | K | L | 1.46 | 0.024 |
| 4 | G | M | A | A | R | M | R | A | V | K | L | 1.23 | 0.009 |
| 5 | G | T | A | A | R | M | R | A | L | K | L | 0.69 | 0.009 |
| 6 | G | M | A | A | R | M | R | D | L | K | L | 0.69 | 0.024 |
| 7 | R | M | A | A | R | M | R | A | L | K | L | 0.54 | 0.009 |
| 8 | G | M | A | A | P | M | H | A | L | K | L | 0.38 | 0.009 |
| 9 | G | M | A | A | R | M | R | A | L | K | * | 0.23 | 1.200 |
| 10 | G | M | A | A | R | V | R | A | L | K | L | 0.15 | 0.009 |
| 11 | G | M | A | T | R | M | R | A | L | K | L | 0.15 | 0.009 |
| 12 | G | M | V | A | R | M | H | D | L | K | L | 0.08 | 0.024 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2M5.aApr07-unspliced | main_exon | CDS | chr1 | 248,145,148 | 248,146,083 | + |
| 3UTR | chr1 | 248,146,083 | 248,146,086 | + | ||