OR2T8 Olfactory Receptor
| Gene Symbol | OR2T81 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | T |
| Pseudogene | No |
| CORP pseudogene probability score | 0.13 (functional) |
| Aliases | HsOR1.5.16 |
| External Ids | HGNC: 15020 GeneBank: AF399488, NM_001005522 |
| Build #39 labels | OR2T8P |
| Chromosomal location | 1:247,921,018-247,921,953 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2T12 | 90.06% | 312 |
| OR2T32P | 91.99% | 312 |
| OR2T33 | 93.59% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2T15 | 77% | 312 |
| Mouse | Or2t44 | 74% | 312 |
| Rat | Or2t44b | 72% | 312 |
| Cow | OR2T13 | 75% | 312 |
| Orang | OR2T8P | 92% | 310 |
| Orang | OR2T32 | 89% | 312 |
| Horse | OR2T69 | 78% | 310 |
| Chimp | OR2T32B | 90% | 312 |
| Chimp | OR2T32 | 90% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BF849296 |
Sequence information
| Nucleotide sequence |
ATGGAAAATGGGAGCTATACCTCTTATTTCATTCTCCTAGGACTCTTTAACCACACCAGA GCCCACCAAGTCCTCTTCATGATGGTTCTGAGTATCGTTTTGACCTCCCTGTTTGGCAAT TCCCTCATGATTCTCCTGATTCACTGGGACCACCGGCTCCACACGCCCATGTACTTCCTC CTGAGCCAACTTTCCCTCATGGACGTGATGCTGGTTTCCACCACTGTGCCCAAAATGGCG GCTGACTACTTGACCGGAAGTAAGGCCATCTCCCGCGCTGGCTGTGGTGCGCAGATCTTC TTCCTCCCCACACTGGGTGGTGGAGAGTGCTTCCTCTTAGCAGCCATGGCCTATGACCGC TATGCGGCTGTCTGCCACCCACTCCGATATCCCACTCTCATGAGCTGGCAGCTGTGCCTG AGGATGAACCTGTCGTGTTGGCTCCTGGGTGCAGCTGACGGGCTCCTGCAGGCTGTTGCT ACCCTGAGCTTCCCATATTGCGGTGCACACGAGATCGATCACTTCTTCTGCGAGACCCCC GTGCTGGTGCGTTTGGCTTGTGCTGACACTTCAGTCTTCGAAAACGCCATGTACATCTGC TGTGTGTTAATGCTCCTGGTCCCCTTTTCCCTCATCCTGTCCTCCTATGGTCTCATCCTC GCTGCTGTTCTGCACATGCGCTCTACAGAAGCCCGCAAGAAGGCCTTTGCCACCTGCTCT TCACATGTGGCTGTGGTGGGACTCTTTTATGGAGCTGCCATTTTTACCTATATGAGACCC AAATCCCACAGGTCCACTAACCACGACAAGGTTGTGTCAGCCTTCTATACTATGTTCACC CCTTTACTAAACCCCCTCATCTACAGTGTGAAGAACAGTGAGGTGAAGGGAGCCCTGACA AGGTGTATGGGTCGGTGTGTGGCCTTAAGTCGTGAA |
| Conceptual translation |
MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFL LSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDR YAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETP VLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCS SHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALT RCMGRCVALSRE Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | C/T | R/W | 1000GP (YRI, YRI) |
| 1 | 247,921,930 | 247,921,930 | NS | C/T | R/W | 1000GP (CHBJPT) |
| 1 | 248,084,434 | 248,084,434 | NS | A/G | S/G | rs11204563 (DbSNP) |
| 1 | 248,084,464 | 248,084,464 | NS | C/T | R/W | rs11204564 (DbSNP) |
| 1 | 248,084,511 | 248,084,511 | SYN | C/T | L/L | rs41315864 (DbSNP) |
| 1 | 248,084,524 | 248,084,524 | NS | A/G | M/V | rs28575687 (DbSNP) |
| 1 | 248,084,589 | 248,084,589 | SYN | C/T | I/I | rs41305969 (DbSNP) |
| 1 | 248,084,625 | 248,084,625 | SYN | C/G | L/L | rs6692365 (DbSNP) |
| 1 | 248,084,627 | 248,084,627 | NS | C/T | P/L | rs61857490 (DbSNP) |
| 1 | 248,084,631 | 248,084,631 | SYN | A/C | T/T | rs28689982 (DbSNP) |
| 1 | 248,084,747 | 248,084,747 | NS | A/C | N/T | rs4523549 (DbSNP) |
| 1 | 248,084,749 | 248,084,749 | NS | A/C | M/L | rs12142488 (DbSNP) |
| 1 | 248,084,825 | 248,084,825 | NS | C/T | A/V | rs61857492 (DbSNP) |
| 1 | 248,084,854 | 248,084,854 | NS | A/G | T/A | rs4584426 (DbSNP) |
| 1 | 248,084,909 | 248,084,909 | NS | G/T | R/M | rs34508376 (DbSNP) |
| 1 | 248,084,980 | 248,084,980 | NS | G/T | A/S | rs4362017 (DbSNP) |
| 1 | 248,085,011 | 248,085,011 | NS | C/G | A/G | rs4595394 (DbSNP) |
| 1 | 248,085,108 | 248,085,108 | SYN | C/T | H/H | rs4625315 (DbSNP) |
| 1 | 248,085,124 | 248,085,124 | NS | A/G | N/D | rs4590708 (DbSNP) |
| 1 | 248,085,232 | 248,085,232 | NS | C/T | R/W | rs6695357 (DbSNP) |
| 1 | 248,085,251 | 248,085,251 | NS | A/G | H/R | rs58882030 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M1T | T277S | R305W | R311H | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | M | T | R | R | 85.10 | 0.285 |
| 2 | M | S | R | R | 9.60 | 0.285 |
| 3 | M | T | R | H | 3.46 | 0.285 |
| 4 | M | T | W | R | 1.46 | 0.285 |
| 5 | T | T | R | R | 0.31 | 1.200 |
| 6 | T | T | R | H | 0.08 | 1.200 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2T8.aApr07 | exon_5UTR | chr1 | 247,920,250 | 247,920,518 | + | |
| main_exon | 5UTR | chr1 | 247,920,998 | 247,921,018 | + | |
| CDS | chr1 | 247,921,018 | 247,921,953 | + | ||
| 3UTR | chr1 | 247,921,953 | 247,921,956 | + | ||