OR4N2 Olfactory Receptor
| Gene Symbol | OR4N21 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | N |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR14-8, OR14-13, HsOR14.1.7, ORL3693 |
| External Ids | HGNC: 14742 GeneBank: AB065885, BK004360, BK004473, NM_001004723 ORDB: ORL3693 |
| Build #39 labels | OR4N2 |
| Chromosomal location | 14:19,827,449-19,828,369 (+) |
| Cluster | 14@20b |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4N1P | 87.09% | 302 |
| OR4N3P | 91.86% | 307 |
| OR4N4 | 85.95% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4N5 | 85% | 307 |
| Dog | OR4N2B | 85% | 306 |
| Mouse | Or4n4 | 84% | 306 |
| Rat | Or4n4 | 81% | 306 |
| Cow | OR4N2C | 86% | 306 |
| Cow | OR4N4 | 85% | 306 |
| Cow | OR4N5 | 83% | 306 |
| Orang | OR4N1P | 87% | 306 |
| Orang | OR4N5 | 86% | 306 |
| Horse | OR4N2D | 91% | 307 |
| Chimp | OR4N5 | 87% | 306 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BM696516 |
| mRNA | AB463965 |
Sequence information
| Nucleotide sequence |
ATGGAAAGCGAGAACAGAACAGTGATAAGAGAATTCATCCTCCTTGGTCTGACCCAGTCT CAAGATATTCAGCTCCTGGTCTTTGTGCTAGTTTTAATATTCTACTTCATCATCCTCCCT GGAAATTTTCTCATTATTTTCACCATAAAGTCAGACCCTGGGCTCACAGCCCCCCTCTAT TTCTTTCTGGGCAACTTGGCCTTCCTGGATGCATCCTACTCCTTCATTGTGGCTCCCCGG ATGTTGGTGGACTTCCTCTCTGCGAAGAAGATAATCTCCTACAGAGGCTGCATCACTCAG CTCTTTTTCTTGCACTTCCTTGGAGGAGGGGAGGGATTACTCCTTGTTGTGATGGCCTTT GACCGCTACATCGCCATCTGCCGGCCTCTGCACTATCCTACTGTCATGAACCCTAGAACC TGCTATGCAATGATGTTGGCTCTGTGGCTTGGGGGTTTTGTCCACTCCATTATCCAGGTG GTCCTCATCCTCCGCTTGCCTTTTTGTGGCCCAAACCAGCTGGACAACTTCTTCTGTGAT GTCCCACAGGTCATCAAGCTGGCCTGCACCGACACATTTGTGGTGGAGCTTCTGATGGTC TTCAACAGTGGCCTGATGACACTCCTGTGCTTTCTGGGGCTTCTGGCCTCCTATGCAGTC ATTCTTTGTCGCATACGAGGGTCTTCTTCTGAGGCAAAAAACAAGGCCATGTCCACGTGC ATCACCCATATCATTGTTATATTCTTCATGTTTGGACCTGGCATCTTCATCTACACGCGC CCCTTCAGGGCTTTCCCAGCTGACAAGGTGGTTTCTCTCTTCCACACAGTGATTTTTCCT TTGTTGAATCCTGTCATTTATACCCTTCGCAACCAGGAAGTGAAAGCTTCCATGAAAAAG GTGTTTAATAAGCACATAGCC |
| Conceptual translation |
MESENRTVIREFILLGLTQSQDIQLLVFVLVLIFYFIILPGNFLIIFTIKSDPGLTAPLY FFLGNLAFLDASYSFIVAPRMLVDFLSAKKIISYRGCITQLFFLHFLGGGEGLLLVVMAF DRYIAICRPLHYPTVMNPRTCYAMMLALWLGGFVHSIIQVVLILRLPFCGPNQLDNFFCD VPQVIKLACTDTFVVELLMVFNSGLMTLLCFLGLLASYAVILCRIRGSSSEAKNKAMSTC ITHIIVIFFMFGPGIFIYTRPFRAFPADKVVSLFHTVIFPLLNPVIYTLRNQEVKASMKK VFNKHIA Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 20,295,727 | 20,295,726 | Ins(1) | -/C | rs34881110 (DbSNP) | |
| 14 | 20,295,627 | 20,295,627 | NS | C/G | T/R | rs72663752 (DbSNP) |
| 14 | 20,295,779 | 20,295,779 | NS | C/G | P/A | rs11621884 (DbSNP) |
| 14 | 20,296,000 | 20,296,000 | NS | C/G | H/Q | rs2873667 (DbSNP) |
| 14 | 20,296,010 | 20,296,010 | NS | C/G | L/V | rs17114261 (DbSNP) |
| 14 | 20,296,025 | 20,296,025 | NS | G/A | A/T | rs2318277 (DbSNP) |
| 14 | 20,295,980 | 20,295,980 | NS | G/A | A/T | rs4060171 (DbSNP) |
| 14 | 20,296,004 | 20,296,004 | NS | T/C | S/P | rs2318279 (DbSNP) |
| 14 | 20,295,834 | 20,295,834 | NS | T/C | I/T | rs2801164 (DbSNP) |
| 14 | 20,295,990 | 20,295,990 | NS | T/G | L/R | rs2318280 (DbSNP) |
| 14 | 20,295,778 | 20,295,778 | SYN | A/C | A/A | rs11621883 (DbSNP) |
| 14 | 20,296,201 | 20,296,201 | SYN | A/G | L/L | rs72484805 (DbSNP) |
| 14 | 20,296,510 | 20,296,510 | SYN | A/G | V/V | rs10149365 (DbSNP) |
| 14 | 20,296,006 | 20,296,006 | SYN | A/T | P/P | rs2318278 (DbSNP) |
| 14 | 20,295,763 | 20,295,763 | SYN | C/T | D/D | rs11621854 (DbSNP) |
| 14 | 19,827,851 | 19,827,851 | NS | G/C | V/L | 1000GP (CEU, CHBJPT) |
| 14 | 19,827,845 | 19,827,845 | NS | C/T | P/S | 1000GP (CEU, CHBJPT) |
| 14 | 19,828,351 | 19,828,351 | SYN | G/A | V/V | 1000GP (CEU) |
| 14 | 19,828,119 | 19,828,119 | NS | G/A | R/H | 1000GP (CHBJPT) |
| 14 | 100 | -100 | NS | C/T | P/S | 1000GP (YRI, YRI) |
| 14 | 100 | -100 | SYN | G/A | V/V | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 20,197,616 | 20,399,048 | CopyNumber | Variation_0316 (DGV) |
| 14 | 20,203,125 | 20,539,108 | CopyNumber | Variation_3036 (DGV) |
| 14 | 19,662,531 | 20,556,187 | CopyNumber | Variation_3929 (DGV) |
| 14 | 20,219,649 | 20,415,445 | CopyNumber | Variation_4826 (DGV) |
| 14 | 19,117,183 | 20,424,605 | CopyNumber | Variation_7028 (DGV) |
| 14 | 20,203,125 | 20,483,660 | CopyNumber | Variation_8762 (DGV) |
| 14 | 20,203,125 | 20,626,160 | CopyNumber | Variation_8763 (DGV) |
| 14 | 20,239,479 | 20,422,583 | CopyNumber | Variation_8764 (DGV) |
| 14 | 20,203,125 | 20,716,841 | CopyNumber | Variation_8765 (DGV) |
| 14 | 20,203,125 | 20,433,044 | CopyNumber | Variation_9234 (DGV) |
| 14 | 20,239,479 | 20,511,107 | CopyNumber | Variation_9235 (DGV) |
| 14 | 20,177,234 | 20,424,604 | CopyNumber | Variation_30648 (DGV) |
| 14 | 19,360,239 | 20,424,604 | CopyNumber | Variation_31953 (DGV) |
| 14 | 20,203,125 | 20,525,833 | CopyNumber | Variation_34547 (DGV) |
| 14 | 20,267,014 | 20,433,060 | CopyNumber | Variation_34563 (DGV) |
| 14 | 20,203,125 | 20,456,434 | CopyNumber | Variation_34575 (DGV) |
| 14 | 20,203,125 | 20,655,466 | CopyNumber | Variation_34656 (DGV) |
| 14 | 20,239,246 | 20,432,988 | CopyNumber | Variation_34659 (DGV) |
| 14 | 20,203,125 | 20,550,348 | CopyNumber | Variation_34660 (DGV) |
| 14 | 20,203,125 | 20,455,307 | CopyNumber | Variation_34664 (DGV) |
| 14 | 19,670,757 | 20,331,117 | CopyNumber | Variation_37621 (DGV) |
| 14 | 20,200,183 | 20,423,372 | CopyNumber | Variation_38951 (DGV) |
| 14 | 19,349,922 | 20,424,856 | CopyNumber | Variation_58655 (DGV) |
| 14 | 20,177,210 | 20,424,753 | CopyNumber | Variation_66584 (DGV) |
| 14 | 19,781,170 | 20,424,776 | CopyNumber | Variation_71833 (DGV) |
| 14 | 20,263,747 | 20,314,312 | CopyNumber | Variation_71834 (DGV) |
| 14 | 20,198,061 | 20,307,453 | CopyNumber | Variation_71859 (DGV) |
| 14 | 20,289,680 | 20,425,312 | CopyNumber | Variation_71860 (DGV) |
| 14 | 20,152,622 | 20,419,574 | CopyNumber | Variation_76554 (DGV), Variation_87112 (DGV) |
| 14 | 20,283,374 | 20,419,574 | CopyNumber | Variation_76556 (DGV) |
| 14 | 20,185,336 | 20,310,638 | CopyNumber | Variation_76557 (DGV) |
| 14 | 20,201,654 | 20,343,302 | CopyNumber | Variation_87118 (DGV) |
| 14 | 20,295,508 | 20,298,528 | CopyNumber | #158 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T7R | I76T | F85I | P133S | V135L | R224H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | T | I | F | P | V | R | 43.01 | 0.490 |
| 2 | T | T | F | P | V | R | 19.89 | 0.490 |
| 3 | T | T | F | S | L | R | 16.82 | 0.490 |
| 4 | T | T | F | S | V | R | 7.68 | 0.490 |
| 5 | R | I | F | P | V | R | 7.22 | 0.490 |
| 6 | T | T | F | P | V | H | 1.92 | 0.490 |
| 7 | T | I | F | S | L | R | 1.84 | 0.490 |
| 8 | T | I | F | S | V | R | 0.61 | 0.490 |
| 9 | T | T | I | P | V | R | 0.54 | 0.490 |
| 10 | T | T | F | P | L | R | 0.23 | 0.490 |
| 11 | T | I | F | P | V | H | 0.15 | 0.490 |
| 12 | T | T | F | S | L | H | 0.08 | 0.490 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4N2.aApr07 | exon_5UTR | chr14 | 19,803,770 | 19,803,844 | + | |
| main_exon | 5UTR | chr14 | 19,827,440 | 19,827,449 | + | |
| CDS_partial | chr14 | 19,827,449 | 19,827,886 | + | ||
| exon_3UTR | chr14 | 19,830,048 | 19,830,226 | + | ||
| OR4N2.bApr07 | exon_5UTR | chr14 | 19,719,015 | 19,719,116 | + | |
| exon_5UTR | chr14 | 19,733,369 | 19,733,463 | + | ||
| exon_5UTR | chr14 | 19,761,888 | 19,761,983 | + | ||
| exon_5UTR | chr14 | 19,822,254 | 19,822,451 | + | ||
| main_exon | 5UTR | chr14 | 19,827,440 | 19,827,449 | + | |
| CDS | chr14 | 19,827,449 | 19,828,369 | + | ||
| 3UTR | chr14 | 19,828,369 | 19,828,372 | + | ||