OR4X2 Olfactory Receptor
| Gene Symbol | OR4X21 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | X |
| Pseudogene | No |
| CORP pseudogene probability score | 0.44 (functional) |
| Aliases | OR11-105, HsOR11.8.3, ORL3383 |
| External Ids | HGNC: 15184 GeneBank: AB065847, AF399580, BK004389, NM_001004727 ORDB: ORL3383 |
| Build #39 labels | OR4X2 |
| Chromosomal location | 11:48,245,104-48,246,012 (+) |
| Cluster | 11@48 |
| Synteny | CLIC#26 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs7120775 (AA change=Y/* ) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4B1 | 61.9% | 294 |
| OR4S2 | 60.73% | 303 |
| OR4X1 | 63.01% | 292 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4X5 | 67% | 298 |
| Mouse | Or4x6 | 79% | 303 |
| Rat | Or4x6 | 78% | 303 |
| Cow | OR4X2B | 81% | 303 |
| Orang | OR4X2P | 93% | 302 |
| Horse | OR4X2C | 83% | 303 |
| Horse | OR4X2D | 82% | 303 |
| Horse | OR4X2EP | 81% | 303 |
| Chimp | OR4S2 | 61% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136936 |
| GNF Atlas2 | gnf1h10945_at |
Sequence information
| Nucleotide sequence |
ATGACTGAATTCATTTTTCTGGTACTTTCTCCCAACCAGGAGGTGCAGAGGGTTTGCTTT GTGATATTTCTGTTCTTGTACACAGCAATTGTGCTGGGGAATTTCCTCATTGTGCTCACT GTCATGACCAGCAGAAGCCTTGGTTCCCCCATGTACTTCTTCCTCAGCTACCTCTCCTTC ATGGAGATCTGCTACTCCTCCGCTACAGCCCCCAAACTCATCTCAGATCTGCTGGCTGAA AGGAAAGTCATATCTTGGTGGGGCTGCATGGCACAGCTTTTCTTCTTGCACTTCTTTGGT GGCACTGAGATTTTCCTGCTCACTGTGATGGCCTATGACCACTATGTGGCCATCTGCAAG CCCCTCAGCTACACCACCATCATGAACTGGCAGGTGTGTACTGTCCTTGTAGGAATAGCA TGGGTGGGAGGCTTCATGCATTCCTTTGCACAAATCCTTCTCATCTTCCACCTGCTCTTC TGTGGCCCCAATGTGATCAATCACTATTTCTGTGACCTAGTTCCCCTTCTCAAACTTGCC TGCTCTGACACCTTCCTCATTGGTCTGCTGATTGTTGCCAATGGAGGCACCCTGTCTGTG ATCAGTTTTGGGGTCCTCTTAGCATCCTATATGGTCATCTTGCTCCATCTGAGAACCTGG AGCTCTGAAGGGTGGTGCAAAGCCCTCTCCACCTGTGGGTCCCATTTCGCTGTGGTTATC TTGTTCTTTGGGCCCTGCGTCTTCAACTCTCTGAGGCCTTCTACCACTCTGCCCATAGAC AAGATGGTGGCTGTGTTCTACACAGTGATAACCGCGATCCTGAACCCTGTCATCTACTCT CTGAGAAATGCTGAAATGAGGAAGGCCATGAAGAGGCTGTGGATTAGGACATTGAGACTA AATGAGAAA |
| Conceptual translation |
MTEFIFLVLSPNQEVQRVCFVIFLFLYTAIVLGNFLIVLTVMTSRSLGSPMYFFLSYLSF MEICYSSATAPKLISDLLAERKVISWWGCMAQLFFLHFFGGTEIFLLTVMAYDHYVAICK PLSYTTIMNWQVCTVLVGIAWVGGFMHSFAQILLIFHLLFCGPNVINHYFCDLVPLLKLA CSDTFLIGLLIVANGGTLSVISFGVLLASYMVILLHLRTWSSEGWCKALSTCGSHFAVVI LFFGPCVFNSLRPSTTLPIDKMVAVFYTVITAILNPVIYSLRNAEMRKAMKRLWIRTLRL NEK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | nonsense SNP | C/G | Y/* | 1000GP (YRI) |
| 11 | 100 | -100 | NS | G/C | V/L | 1000GP (YRI, YRI) |
| 11 | 100 | -100 | SYN | T/A | T/T | 1000GP (YRI) |
| 11 | 48,245,184 | 48,245,184 | nonsense SNP | C/G | Y/* | 1000GP (CEU, CHBJPT) |
| 11 | 48,245,427 | 48,245,427 | SYN | T/A | T/T | 1000GP (CEU, CHBJPT) |
| 11 | 48,245,428 | 48,245,428 | NS | G/C | V/L | 1000GP (CEU, CHBJPT) |
| 11 | 48,245,537 | 48,245,537 | NS | T/C | F/S | 1000GP (CEU) |
| 11 | 48,245,986 | 48,245,986 | NS | A/G | I/V | 1000GP (CHBJPT) |
| 11 | 48,266,736 | 48,266,736 | nonsense SNP | C/G | Y/* | rs7120775 (DbSNP) |
| 11 | 48,266,857 | 48,266,857 | NS | G/T | A/S | rs61737299 (DbSNP) |
| 11 | 48,267,468 | 48,267,468 | SYN | C/T | T/T | rs60356906 (DbSNP) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| E14K | Y27* | G144D | % Freq | CORP | |
|---|---|---|---|---|---|
| 1 | E | Y | G | 83.33 | 0.737 |
| 2 | E | * | G | 16.13 | 1.200 |
| 3 | K | Y | G | 0.38 | 0.737 |
| 4 | E | Y | D | 0.15 | 0.737 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4X2.aApr07-unspliced | main_exon | CDS | chr11 | 48,245,104 | 48,246,012 | + |
| 3UTR | chr11 | 48,246,012 | 48,246,015 | + | ||