OR52A5 Olfactory Receptor
| Gene Symbol | OR52A51 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.18 (functional) |
| Aliases | OR11-33, HsOR11.3.50 |
| External Ids | HGNC: 19580 GeneBank: AY726590, BK004433, NM_001005160 |
| Build #39 labels | OR52A5 |
| Chromosomal location | 11:5,131,695-5,132,642 (-) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52A1 | 74.84% | 310 |
| OR52A4 | 69.96% | 263 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52A5C | 81% | 313 |
| Mouse | Or52a5 | 82% | 314 |
| Mouse | Or52a5b | 81% | 314 |
| Rat | Or52a5 | 82% | 314 |
| Rat | Or52a5b | 81% | 314 |
| Cow | OR52A5D | 84% | 310 |
| Cow | OR52A5EP | 82% | 318 |
| Orang | OR52A1 | 75% | 310 |
| Horse | OR52A5F | 85% | 314 |
| Chimp | OR52A5D | 98% | 316 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463976 |
| GNF Atlas2 | gnf1h10900_at |
Sequence information
| Nucleotide sequence |
ATGCCGACATTCAATGGCTCAGTCTTCATGCCCTCTGCGTTTATACTAATTGGGATTCCT GGTCTGGAGTCAGTGCAGTGTTGGATTGGGATTCCTTTCTCTGCCATGTATCTTATTGGT GTGATTGGAAATTCCCTAATTTTAGTTATAATCAAATATGAAAACAGCCTCCATATACCC ATGTACATTTTTTTGGCCATGTTGGCAGCCACAGACATTGCACTTAACACCTGCATTCTT CCCAAAATGTTAGGCATCTTCTGGTTTCATTTGCCAGAGATTTCTTTTGATGCCTGTCTT TTTCAAATGTGGCTTATTCACTCATTCCAGGCAATTGAATCGGGTATCCTTCTGGCAATG GCCCTGGATCGCTATGTGGCCATCTGTATCCCCTTGAGACATGCCACCATCTTTTCCCAG CAGTTCTTAACTCATATTGGACTTGGGGTGACACTCAGGGCTGCCATTCTTATAATACCT TCCTTAGGGCTCATCAAATGCTGTCTGAAACACTATCGAACTACAGTCATCTCTCACTCT TACTGTGAGCACATGGCCATCGTGAAGCTGGCTACTGAAGATATCCGAGTCAACAAGATA TATGGCCTATTTGTTGCCTTTGCAATCCTAGGGTTTGACATAATATTTATAACCTTGTCC TATGTCCAAATTTTTATCACTGTCTTTCAGCTGCCCCAGAAGGAGGCACGATTCAAGGCC TTTAATACATGCATTGCCCACATTTGTGTCTTCCTACAGTTCTACCTTCTTGCCTTCTTC TCTTTCTTCACACACAGGTTTGGTTCACACATACCACCATATATTCATATCCTCTTGTCA AATCTTTACCTGTTAGTCCCACCTTTTCTCAACCCTATTGTCTATGGAGTGAAGACCAAG CAAATTCGTGACCATATTGTGAAAGTGTTTTTCTTCAAAAAAGTAACT |
| Conceptual translation |
MPTFNGSVFMPSAFILIGIPGLESVQCWIGIPFSAMYLIGVIGNSLILVIIKYENSLHIP MYIFLAMLAATDIALNTCILPKMLGIFWFHLPEISFDACLFQMWLIHSFQAIESGILLAM ALDRYVAICIPLRHATIFSQQFLTHIGLGVTLRAAILIIPSLGLIKCCLKHYRTTVISHS YCEHMAIVKLATEDIRVNKIYGLFVAFAILGFDIIFITLSYVQIFITVFQLPQKEARFKA FNTCIAHICVFLQFYLLAFFSFFTHRFGSHIPPYIHILLSNLYLLVPPFLNPIVYGVKTK QIRDHIVKVFFFKKVT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,152,966 | 5,152,966 | NS | A/G | C/R | rs74051330 (DbSNP) |
| 11 | 5,153,400 | 5,153,400 | NS | A/G | I/T | rs73396832 (DbSNP) |
| 11 | 5,152,957 | 5,152,957 | NS | C/T | V/I | rs74051326 (DbSNP) |
| 11 | 5,153,261 | 5,153,261 | SYN | G/A | F/F | rs2472530 (DbSNP) |
| 11 | 5,132,031 | 5,132,031 | SYN | A/G | F/F | 1000GP (CEU, CHBJPT) |
| 11 | 5,131,823 | 5,131,823 | NS | A/G | Y/H | 1000GP (CEU) |
| 11 | 100 | -100 | NS | T/C | I/V | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,150,925 | 5,153,972 | CopyNumber | #58 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I306V | R303C | Y274H | K239E | I187V | I158T | V25L | P2L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | R | Y | K | I | I | V | P | 94.39 | 0.401 |
| 2 | V | R | Y | K | I | I | V | P | 3.00 | 0.401 |
| 3 | I | R | Y | K | I | I | V | L | 0.77 | 0.401 |
| 4 | V | C | Y | K | I | I | V | P | 0.61 | 0.401 |
| 5 | I | R | Y | E | I | I | V | P | 0.38 | 0.401 |
| 6 | I | R | H | K | I | I | V | P | 0.31 | 0.401 |
| 7 | V | R | Y | K | V | I | V | P | 0.23 | 0.401 |
| 8 | I | R | Y | K | I | T | V | P | 0.23 | 0.401 |
| 9 | I | R | Y | K | I | I | L | P | 0.08 | 0.401 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52A5.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,131,692 | 5,131,695 | - |
| CDS | chr11 | 5,131,695 | 5,132,642 | - | ||