OR52L1 Olfactory Receptor
| Gene Symbol | OR52L11 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-50, HsOR11.3.92, ORL3285 |
| External Ids | HGNC: 14785 GeneBank: AB065819, AY284549-AY284580, BK004253, NM_001005173 ORDB: ORL3285 |
| Build #39 labels | OR52L1 |
| Chromosomal location | 11:5,985,944-5,986,885 (-) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs4436525) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52L2P | 91.4% | 314 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52L2 | 85% | 313 |
| Mouse | Or52l1 | 86% | 313 |
| Rat | Or52l1b | 87% | 313 |
| Rat | Or52l1 | 87% | 313 |
| Cow | OR52L2 | 87% | 311 |
| Orang | OR52L2 | 92% | 314 |
| Horse | OR52L2 | 88% | 310 |
| Chimp | OR52L2P | 92% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC137343 |
Sequence information
| Nucleotide sequence |
ATGCTCCTTAGCAATTCAAGCTGGAGGCTATCCCAGCCTTCTTTTCTCCTGGTAGGGATT CCAGGTTTAGAGGAAAGCCAGCACTGGATTGCACTGCCCCTGGGCATCCTTTACCTCCTT GCTTTAGTGGGCAATGTTACCATTCTCTTCATCATCTGGATGGACCCATCCTTGCACCAA TCTATGTACCTCTTCCTGTCCATGCTAGCTGCCATCGACCTGGTTCTGGCCTCCTCCACT GCACCCAAAGCCCTTGCAGTGCTCCTGGTTCATGCCCACGAGATTGGGTACATCGTCTGC CTGATCCAGATGTTCTTCATCCATGCATTCTCCTCCATGGAGTCAGGGGTACTTGTGGCC ATGGCTCTGGATTGCTATGTAGCCATTTGTCACCCCTTGCACCATTCCACAATCCTGCAT CCAGGGGTCATAGGGTGCATCGGAATGGTGGTGCTGGTGAGGGGATTACTACTCCTTATC CCCTTCCCCATTTTGTTGGGAAAACTTATCTTCTGCCAAGCCACCATCATAGGCCATGCC TATTGTGAACATATGGCTGTTGTGAAACTTGCCTGCTCAGAAACCACAGTCAATCGAGCT TATGGGCTGACTATGGCCTTGCTTGTGATTGGGCTGGATGTTCTGGCCATTGGTGTTTCC TATGCCCACATCCTCCAGGCAGTGCTGAAGGTACCAGGGAGTGAGGCCCGACTTAAGGCG TTTAGCACATGTGGCTCTCATATTTGTGTCATCCTGGTCTTCTATGTCCCTGGAATTTTC TCCTTCCTCACTCACCGCTTTGGTCATCATGTACCCCATCATGTCCATGTTCTTCTGGCC ACATGGTATCTCCTCATGCCACCTGCGCTCAATCCTCTTGTCTATGGAGTGAAGACTCAG CAGATCCGCCAGCGAGTGCTCAGAGTGTTTACACAAAAGGAT |
| Conceptual translation |
MLLSNSSWRLSQPSFLLVGIPGLEESQHWIALPLGILYLLALVGNVTILFIIWMDPSLHQ SMYLFLSMLAAIDLVLASSTAPKALAVLLVHAHEIGYIVCLIQMFFIHAFSSMESGVLVA MALDCYVAICHPLHHSTILHPGVIGCIGMVVLVRGLLLLIPFPILLGKLIFCQATIIGHA YCEHMAVVKLACSETTVNRAYGLTMALLVIGLDVLAIGVSYAHILQAVLKVPGSEARLKA FSTCGSHICVILVFYVPGIFSFLTHRFGHHVPHHVHVLLATWYLLMPPALNPLVYGVKTQ QIRQRVLRVFTQKD Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 6,007,410 | 6,007,409 | Ins(1) | -/G | rs35528253 (DbSNP) | |
| 11 | 6,007,743 | 6,007,743 | NS | A/G | C/R | rs4436525 (DbSNP) |
| 11 | 6,007,874 | 6,007,874 | NS | A/G | V/A | rs72484715 (DbSNP) |
| 11 | 6,007,272 | 6,007,272 | NS | A/G | W/R | rs4237768 (DbSNP) |
| 11 | 6,007,680 | 6,007,680 | NS | A/G | C/R | rs4436524 (DbSNP) |
| 11 | 6,007,899 | 6,007,899 | NS | C/T | D/N | rs4501959 (DbSNP) |
| 11 | 6,007,772 | 6,007,772 | NS | G/A | S/L | rs61750896 (DbSNP) |
| 11 | 6,007,613 | 6,007,613 | NS | G/T | T/K | rs4354673 (DbSNP) |
| 11 | 6,007,679 | 6,007,679 | NS | T/C | Y/C | rs61742092 (DbSNP) |
| 11 | 6,007,294 | 6,007,294 | SYN | G/A | H/H | rs61752597 (DbSNP) |
| 11 | 6,008,050 | 6,008,050 | SYN | G/A | G/G | rs61738944 (DbSNP) |
| 11 | 6,007,396 | 6,007,396 | SYN | T/C | A/A | rs61732631 (DbSNP) |
| 11 | 5,986,041 | 5,986,041 | nonsense SNP | C/T | W/* | 1000GP (CEU) |
| 11 | 5,986,166 | 5,986,166 | SYN | C/T | A/A | 1000GP (CEU, CHBJPT) |
| 11 | 5,986,669 | 5,986,669 | NS | C/T | D/N | 1000GP (CEU, CHBJPT) |
| 11 | 5,986,450 | 5,986,450 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,986,042 | 5,986,042 | NS | A/G | W/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,986,383 | 5,986,383 | NS | T/G | K/T | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | A/G | W/R | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/A | V/V | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,868,055 | 6,007,613 | CopyNumber | Variation_2903 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T326I | R320Q | W297R | A255V | K183T | C161Y | C161R | C140R | S130L | D88N | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | T | R | R | A | T | C | R | R | S | D | 52.69 | 0.288 |
| 2 | T | R | R | A | T | C | R | R | S | N | 17.28 | 0.288 |
| 3 | T | R | W | A | K | C | C | C | L | D | 10.14 | 0.288 |
| 4 | T | R | R | A | K | C | C | R | S | D | 6.53 | 0.288 |
| 5 | T | R | W | A | K | C | C | C | S | D | 4.69 | 0.288 |
| 6 | T | R | R | A | T | C | R | C | S | D | 2.76 | 0.288 |
| 7 | T | R | R | V | K | C | R | R | S | D | 1.38 | 0.288 |
| 8 | T | R | R | A | K | Y | R | R | S | D | 1.15 | 0.288 |
| 9 | T | R | R | A | K | C | C | C | S | D | 0.92 | 0.288 |
| 10 | T | R | R | A | K | C | R | R | S | D | 0.61 | 0.288 |
| 11 | T | R | R | A | T | C | R | C | S | N | 0.54 | 0.288 |
| 12 | T | Q | W | A | K | C | C | C | L | D | 0.54 | 0.288 |
| 13 | T | R | R | A | T | C | C | R | S | D | 0.15 | 0.288 |
| 14 | T | R | W | A | K | C | R | C | L | D | 0.08 | 0.288 |
| 15 | T | R | R | V | T | C | R | R | S | N | 0.08 | 0.288 |
| 16 | I | R | R | A | T | C | R | R | S | N | 0.08 | 0.288 |
| 17 | T | R | R | A | K | C | C | R | S | N | 0.08 | 0.288 |
| 18 | T | R | W | A | T | C | R | R | S | D | 0.08 | 0.288 |
| 19 | T | R | R | A | T | C | R | R | L | N | 0.08 | 0.288 |
| 20 | T | R | W | A | K | C | C | R | S | D | 0.08 | 0.288 |
| 21 | T | R | W | A | T | C | R | C | S | D | 0.08 | 0.288 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52L1.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,985,941 | 5,985,944 | - |
| CDS | chr11 | 5,985,944 | 5,986,885 | - | ||
| 5UTR | chr11 | 5,986,885 | 5,986,930 | - | ||