OR6B1 Olfactory Receptor
| Gene Symbol | OR6B11 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | OR7-3, OR7-9, WUGSC:H_DJ0669B10.3, HsOR7.6.9, ORL3368 |
| External Ids | HGNC: 8354 GeneBank: AF399605, BK004216, NM_001005281 ORDB: ORL3368 |
| Build #39 labels | OR6B1 |
| Chromosomal location | 7:144,003,997-144,004,929 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6A2 | 57.84% | 306 |
| OR6P1 | 57.63% | 295 |
| OR6Y1 | 54.52% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6B9 | 62% | 303 |
| Mouse | Or6b1 | 93% | 311 |
| Rat | Or6b1 | 92% | 311 |
| Cow | OR6B6 | 62% | 300 |
| Orang | OR6B3P | 58% | 303 |
| Horse | OR6B9 | 61% | 303 |
| Chimp | OR6B1P | 99% | 311 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG357682 |
| mRNA | BC137047 |
Sequence information
| Nucleotide sequence |
ATGGAGTTGGAGAACCAGACACGAGTCACCAAGTTCATTCTGGTGGGATTCCCTGGGAGC TTGAGTATGCGGGCAGCCATGTTTCTGATATTCCTTGTGGCCTATATTCTGACAGTGGCT GAAAACGTGATCATCATCCTATTGGTGCTGCAAAATCGGCCACTGCACAAGCCTATGTAC TTCTTCCTGGCCAACCTGTCCTTCTTGGAGACCTGGTACATCTCTGTGACTGTGCCCAAG TTACTGTTTAGTTTTTGGTCTGTGAACAACAGCATCTCTTTCACACTCTGTATGATACAA CTGTACTTCTTCATTGCTCTCATGTGCACAGAATGTGTGCTTCTGGCCGCCATGGCCTAT GACCGGTATGTGGCCATCTGTCGCCCACTCCACTACCCAACCATAATGAGCCATGGGCTC TGCTTCCGCCTCGCTCTTGGTTCCTGGGCCATTGGCTTTGGCATCTCCCTGGCGAAGATC TACTTCATCTCCTGCCTCAGCTTCTGTGGTCCCAATGTCATCAACCACTTCTTCTGTGAC ATCTCTCCAGTACTTAATCTCTCCTGCACAGACATGTCCATAACTGAGTTGGTAGACTTT ATCCTGGCACTGGTCATCTTCCTATTCCCACTCTTTATTACTGTCCTGTCCTACGGATGC ATTCTGGCCACCATATTATGCATGCCCACAGGAAAGCAGAAAGCGTTCTCCACTTGTGCC TCCCATCTTGTGGTGGTCACCATTTTCTATTCAGCCATTATTTTCATGTATGCTCGACCT CGAGTTATCCATGCCTTCAACATGAACAAAATTATTTCCATCTTCTATGCCATTGTCACT CCTTCTCTCAACCCTTTCATTTATTGCCTAAGAAACCGAGAGGTCAAGGAAGCTCTGAAG AAACTGGCATATTGCCAGGCCAGCAGATCTGAC |
| Conceptual translation |
MELENQTRVTKFILVGFPGSLSMRAAMFLIFLVAYILTVAENVIIILLVLQNRPLHKPMY FFLANLSFLETWYISVTVPKLLFSFWSVNNSISFTLCMIQLYFFIALMCTECVLLAAMAY DRYVAICRPLHYPTIMSHGLCFRLALGSWAIGFGISLAKIYFISCLSFCGPNVINHFFCD ISPVLNLSCTDMSITELVDFILALVIFLFPLFITVLSYGCILATILCMPTGKQKAFSTCA SHLVVVTIFYSAIIFMYARPRVIHAFNMNKIISIFYAIVTPSLNPFIYCLRNREVKEALK KLAYCQASRSD Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,701,726 | 143,701,726 | NS | A/G | I/V | rs61731391 (DbSNP) |
| 7 | 143,701,516 | 143,701,516 | NS | C/T | R/C | rs7787378 (DbSNP) |
| 7 | 143,701,471 | 143,701,471 | NS | C/T | R/C | rs28532725 (DbSNP) |
| 7 | 143,701,224 | 143,701,224 | SYN | C/T | I/I | rs61736970 (DbSNP) |
| 7 | 143,701,884 | 143,701,884 | SYN | C/T | A/A | rs728275 (DbSNP) |
| 7 | 144,004,791 | 144,004,791 | SYN | C/T | A/A | 1000GP (CEU, CHBJPT) |
| 7 | 144,004,423 | 144,004,423 | NS | C/T | R/C | 1000GP (CEU, CHBJPT) |
| 7 | 100 | -100 | SYN | C/T | I/I | 1000GP (YRI, YRI) |
| 7 | 100 | -100 | NS | C/T | R/C | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,615,165 | 143,744,519 | CopyNumber | Variation_0110 (DGV) |
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,208,034 | 143,736,035 | CopyNumber | Variation_5247 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,677,645 | 143,716,639 | CopyNumber | Variation_36642 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
| 7 | 143,700,990 | 143,704,022 | CopyNumber | #113 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A117T | R128C | R143C | A307S | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | A | R | R | A | 83.56 | 0.078 |
| 2 | A | R | C | A | 14.21 | 0.078 |
| 3 | A | C | R | A | 1.38 | 0.078 |
| 4 | T | R | C | A | 0.38 | 0.078 |
| 5 | T | R | R | A | 0.31 | 0.078 |
| 6 | A | C | C | A | 0.08 | 0.078 |
| 7 | A | R | R | S | 0.08 | 0.078 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6B1.aApr07-unspliced | main_exon | CDS | chr7 | 144,003,997 | 144,004,929 | + |
| 3UTR | chr7 | 144,004,929 | 144,004,983 | + | ||