OR6B2 Olfactory Receptor
| Gene Symbol | OR6B21 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.31 (functional) |
| Aliases | OR2-1, HsOR2.4.1 |
| External Ids | HGNC: 15041 GeneBank: AB065663, BC065821, BK004288, NM_001005853 |
| Build #39 labels | OR6B2P |
| Chromosomal location | 2:240,029,494-240,030,429 (-) |
| Cluster | 2@241 |
| Synteny | CLIC#7 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6B3 | 95.44% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6B2C | 83% | 312 |
| Dog | OR6B2D | 83% | 309 |
| Mouse | Or6b3 | 88% | 309 |
| Mouse | Or6b2 | 86% | 312 |
| Mouse | Or6b2b | 86% | 310 |
| Rat | Or6b3 | 88% | 310 |
| Rat | Or6b2b | 86% | 310 |
| Rat | Or6b2 | 86% | 309 |
| Cow | OR6B3 | 83% | 311 |
| Orang | OR6B3P | 92% | 306 |
| Horse | OR6B2C | 83% | 312 |
| Chimp | OR6B3 | 94% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BQ893658 |
| mRNA | BC137562 |
| GNF Atlas2 | gnf1h05804_at |
Sequence information
| Nucleotide sequence |
ATGAGTGGGGAGAATGTCACCAAGGTCAGCACCTTCATCCTGGTGGGCCTCCCCACGGCC CCAGGGCTGCAGTACCTGCTCTTCCTCCTCTTCCTGCTCACCTACCTCTTTGTCCTGGTG GAGAACCTGGCCATCATCCTCATCGTCTGGAGCAGCACCTCCCTCCACAGGCCCATGTAC TACTTTCTGAGCTCCATGTCTTTCCTGGAGATCTGGTACGTGTCTGACATCACCCCCAAG ATGCTGGAGGGCTTCCTCCTCCAGCAGAAACGCATCTCTTTCGTCGGGTGCATGACGCAG CTCTACTTCTTCAGCTCCCTGGTGTGCACCGAGTGTGTGCTTCTGGCCTCCATGGCCTAC GACCGCTACGTGGCCATCTGCCACCCGCTGCGCTACCACGTCCTTGTGACCCCGGGGCTG TGCCTCCAGCTGGTGGGCTTCTCCTTTGTGAGTGGCTTCACCATCTCCATGATCAAGGTC TGTTTTATCTCCAGCGTCACGTTCTGTGGCTCCAACGTCTTGAACCACTTCTTCTGTGAC ATTTCCCCCATCCTCAAGCTGGCCTGCACGGACTTCTCCACTGCAGAGCTGGTGGATTTC ATCCTGGCCTTCATCATCCTGGTGTTTCCGCTCCTGGCCACCATACTGTCATATTGGCAC ATCACCCTGGCTGTCCTGCGCATCCCCTCGGCCACCGGCTGCTGGAGAGCCTTCTCTACC TGCGCCTCTCACCTCACCGTGGTCACCGTCTTCTATACAGCCTTGCTTTTCATGTATGTC CGGCCCCAAGCCATTGATTCCCAGAGCTCCAACAAGCTCATCTCTGCCGTGTACACTGTT GTCACGCCAATAATTAACCCTTTGATTTACTGCCTGAGGAACAAGGAATTTAAGGACGCC TTGAAAAAGGCCTTGGGCTTGGGTCAAACTTCACAC |
| Conceptual translation |
MSGENVTKVSTFILVGLPTAPGLQYLLFLLFLLTYLFVLVENLAIILIVWSSTSLHRPMY YFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLYFFSSLVCTECVLLASMAY DRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKVCFISSVTFCGSNVLNHFFCD ISPILKLACTDFSTAELVDFILAFIILVFPLLATILSYWHITLAVLRIPSATGCWRAFST CASHLTVVTVFYTALLFMYVRPQAIDSQSSNKLISAVYTVVTPIINPLIYCLRNKEFKDA LKKALGLGQTSH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 2 | 240,969,168 | 240,969,168 | NS | A/G | C/R | rs60841887 (DbSNP) |
| 2 | 240,969,312 | 240,969,312 | NS | A/G | C/R | rs10187574 (DbSNP) |
| 2 | 240,969,456 | 240,969,456 | NS | A/G | C/R | rs73107456 (DbSNP) |
| 2 | 240,969,704 | 240,969,704 | NS | A/G | I/T | rs62617786 (DbSNP) |
| 2 | 240,969,044 | 240,969,044 | NS | A/T | L/Q | rs61730693 (DbSNP) |
| 2 | 240,969,012 | 240,969,012 | NS | C/T | A/T | rs61730689 (DbSNP) |
| 2 | 240,969,198 | 240,969,198 | NS | G/A | P/S | rs61730687 (DbSNP) |
| 2 | 240,969,179 | 240,969,179 | NS | G/A | P/L | rs61730686 (DbSNP) |
| 2 | 240,969,837 | 240,969,837 | NS | T/C | K/E | rs61730683 (DbSNP) |
| 2 | 240,969,340 | 240,969,340 | SYN | A/G | C/C | rs10187585 (DbSNP) |
| 2 | 240,969,367 | 240,969,367 | SYN | C/G | V/V | rs73107432 (DbSNP) |
| 2 | 240,969,244 | 240,969,244 | SYN | G/A | I/I | rs61730688 (DbSNP) |
| 2 | 240,029,762 | 240,029,762 | NS | A/G | L/P | 1000GP (CEU) |
| 2 | 240,029,765 | 240,029,765 | NS | G/A | T/I | 1000GP (CHBJPT) |
| 2 | 100 | -100 | NS | T/A | Q/L | 1000GP (YRI) |
| 2 | 100 | -100 | SYN | C/T | K/K | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 2 | 240,911,276 | 241,082,695 | CopyNumber | Variation_0031 (DGV) |
| CopyNumber | 120 (Hasin) | |||
| 2 | 240,969,805 | 240,970,032 | Del(-19) | #2(modil) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T279A | Q268L | R227C | L223P | T222I | S217P | E4K | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | T | Q | R | L | T | S | E | 95.47 | 0.447 |
| 2 | T | L | R | L | T | S | E | 1.38 | 0.447 |
| 3 | T | Q | C | L | T | S | K | 1.23 | 0.447 |
| 4 | T | Q | R | L | I | S | E | 1.08 | 0.447 |
| 5 | T | Q | R | P | T | S | E | 0.38 | 0.447 |
| 6 | A | Q | R | L | T | S | E | 0.31 | 0.447 |
| 7 | T | Q | R | L | T | P | E | 0.15 | 0.705 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6B2.aApr07 | main_exon | 3UTR | chr2 | 240,028,966 | 240,029,494 | - |
| CDS | chr2 | 240,029,494 | 240,030,429 | - | ||
| 5UTR | chr2 | 240,030,429 | 240,030,454 | - | ||
| exon_5UTR | chr2 | 240,032,893 | 240,032,913 | - | ||